An emerging role for Wnt and <scp>GSK3</scp> signaling pathways in schizophrenia

Schizophrenia is a disabling illness with limited treatment options. The underlying pathophysiology remains unknown, partially due to its heterogeneous nature, and a lack of understanding of the biological functions of genetic risk factors. Several signaling pathways have been implicated, however, with the varying degrees of support. In this article, I will focus on the converging evidence supporting a prominent role for Wnt and glycogen synthase kinase 3 (GSK3) signaling in the biological bases of schizophrenia. This includes current pharmacological therapies that target GSK3, animal model and cell‐based studies, and recent human genetic findings that implicate Wnt and GSK3 signaling.

An emerging role for Wnt and GSK3 signaling pathways in schizophrenia Journal Articles