Journal article
Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise
Abstract
Mechanistic target of rapamycin (mTOR) resides as two complexes within skeletal muscle. mTOR complex 1 [mTORC1-regulatory associated protein of mTOR (Raptor) positive] regulates skeletal muscle growth, whereas mTORC2 [rapamycin-insensitive companion of mTOR (Rictor) positive] regulates insulin sensitivity. To examine the regulation of these complexes in human skeletal muscle, we utilized immunohistochemical analysis to study the localization of …
Authors
Hodson N; McGlory C; Oikawa SY; Jeromson S; Song Z; Rüegg MA; Hamilton DL; Phillips SM; Philp A
Journal
American Journal of Physiology - Cell Physiology, Vol. 313, No. 6, pp. c604–c611
Publisher
American Physiological Society
Publication Date
December 1, 2017
DOI
10.1152/ajpcell.00176.2017
ISSN
0363-6143
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultDietary CarbohydratesDietary ProteinsEatingEnergy MetabolismExerciseHumansLysosomal-Associated Membrane Protein 2LysosomesMaleMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Muscle ContractionProtein TransportProto-Oncogene Proteins c-aktQuadriceps MuscleRapamycin-Insensitive Companion of mTOR ProteinRegulatory-Associated Protein of mTORResistance TrainingRibosomal Protein S6 Kinases, 70-kDaSarcolemmaTime FactorsYoung Adult