Oncostatin M Concept

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• A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent  Academic Article
• A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.  Academic Article
• Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model  Academic Article
• Adenoviral Transfer of Murine Oncostatin M Elicits Periosteal Bone Apposition in Knee Joints of Mice, Despite Synovial Inflammation and Up-Regulated Expression of Interleukin-6 and Receptor Activator of Nuclear Factor-κB Ligand  Academic Article
• Adenoviral Transfer of the Murine Oncostatin M Gene Suppresses Dextran-Sodium Sulfate-Induced Colitis  Academic Article
• Adenovirus Vector Expressing Mouse Oncostatin M Induces Acute-Phase Proteins and TIMP-1 ExpressionIn Vivoin Mice  Academic Article
• Antibodies to rat soluble IL-6 receptor stimulate B9 hybridoma cell proliferation  Academic Article
• Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130)  Academic Article
• Direct anti-cancer effect of oncostatin M on chondrosarcoma  Academic Article
• Endotoxin-induced Renal Inflammatory Response  Academic Article
• Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M  Academic Article
• Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: A comparative study in gene-deficient mice  Academic Article
• IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M  Academic Article
• Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling  Academic Article
• Interaction between oncostatin M, interleukin 1 and prostaglandin E2 in induction of IL-6 expression in human fibroblasts  Academic Article
• Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: Implications for cartilage destruction and repair  Academic Article
• Matrix catabolism in arthritis: priming the guns with oncostatin M.  Academic Article
• Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis  Academic Article
• Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes  Academic Article
• Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts  Academic Article
• Modulation of extracellular matrix using adenovirus vectors  Academic Article
• Murine Oncostatin M Stimulates Mouse Synovial Fibroblasts in Vitro and Induces Inflammation and Destruction in Mouse Joints in Vivo  Academic Article
• Novel function of Oncostatin M as a potent tumour-promoting agent in lung  Academic Article
• Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1  Academic Article
• Oncostatin M Induces Bone Loss and Sensitizes Rat Osteosarcoma to the Antitumor Effect of Midostaurin In vivo  Academic Article
• Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716  Academic Article
• Oncostatin M Regulates Eotaxin Expression in Fibroblasts and Eosinophilic Inflammation in C57BL/6 Mice  Academic Article
• Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter  Academic Article
• Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells  Academic Article
• Oncostatin M in combination with tumor necrosis factor ? induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo  Academic Article
• Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2⁺CD4⁺lymphocytes  Academic Article
• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways  Academic Article
• Oncostatin M inhibits IL-1-induced expression of IL-8 and granulocyte-macrophage colony-stimulating factor by synovial and lung fibroblasts.  Academic Article
• Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice  Academic Article
• Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation  Academic Article
• Oncostatin M regulates osteogenic differentiation of murine adipose-derived mesenchymal progenitor cells through a PKCdelta-dependent mechanism  Academic Article
• Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro  Academic Article
• Oncostatin M, but Not Interleukin-6 or Leukemia Inhibitory Factor, Stimulates Expression of Alpha1-Proteinase Inhibitor in A549 Human Alveolar Epithelial Cells  Academic Article
• Oncostatin M-Induced IL-6 Expression in Murine Fibroblasts Requires the Activation of Protein Kinase Cδ  Academic Article
• Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6  Academic Article
• Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis  Academic Article
• Pulmonary Expression of Oncostatin M (OSM) Promotes Inducible BALT Formation Independently of IL-6, Despite a Role for IL-6 in OSM-Driven Pulmonary Inflammation  Academic Article
• RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo  Academic Article
• Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.  Academic Article
• Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M  Academic Article
• Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells  Academic Article
• Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6.  Academic Article
• STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE  Academic Article
• Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.  Academic Article
• Separate roles of IL-6 and oncostatin M in mouse macrophage polarizationin vitroandin vivo  Academic Article
• Type I Interferon Signaling is Required for Oncostatin-M Driven Inflammatory Responses in Mouse Lung  Academic Article