Journal article
Adenoviral Transfer of Murine Oncostatin M Elicits Periosteal Bone Apposition in Knee Joints of Mice, Despite Synovial Inflammation and Up-Regulated Expression of Interleukin-6 and Receptor Activator of Nuclear Factor-κB Ligand
Abstract
Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro. To elucidate the in vivo effect of OSM on bone remodeling, we injected an adenoviral vector encoding murine OSM in knee joints of mice. OSM strongly induced interleukin (IL)-6 gene expression, a known mediator of osteoclast development. We investigated the OSM effect in wild-type and IL-6-deficient mice and …
Authors
de Hooge ASK; van de Loo FAJ; Bennink MB; de Jong DS; Arntz OJ; Lubberts E; Richards CD; van den Berg WB
Journal
American Journal Of Pathology, Vol. 160, No. 5, pp. 1733–1743
Publisher
Elsevier
Publication Date
May 2002
DOI
10.1016/s0002-9440(10)61120-0
ISSN
0002-9440
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAlkaline PhosphataseAnimalsArthritisBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCarrier ProteinsCell LineDose-Response Relationship, DrugGene ExpressionGene Transfer TechniquesGenotypeGlycoproteinsInterleukin-6Knee JointMaleMembrane GlycoproteinsMiceMice, Inbred C57BLOncostatin MOsteogenesisOsteoprotegerinPeptidesPeriosteumRANK LigandReceptor Activator of Nuclear Factor-kappa BReceptors, Cytoplasmic and NuclearReceptors, Tumor Necrosis FactorRecombinant ProteinsSpecific Pathogen-Free OrganismsSynovitisTransforming Growth Factor betaUp-Regulation