Journal article
Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.
Abstract
Acute inflammation is characterized by increased liver output of acute phase proteins (APP). Several cytokines including IL-6, leukemia inhibitory factor, and IL-11 are capable of stimulating APP synthesis by hepatocytes and hepatoma cells. We have tested the activity of a separate and unique cytokine oncostatin M (OM) and have found potent APP-inducing activity of human recombinant OM on hepatocytes. OM acted in a dose-dependent fashion (ED50 …
Authors
Richards CD; Brown TJ; Shoyab M; Baumann H; Gauldie J
Journal
The Journal of Immunology, Vol. 148, No. 6, pp. 1731–1736
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 1992
DOI
10.4049/jimmunol.148.6.1731
ISSN
0022-1767