Journal article
Adenovirus Vector Expressing Mouse Oncostatin M Induces Acute-Phase Proteins and TIMP-1 Expression In Vivo in Mice
Abstract
Mouse oncostatin M (MuOSM) regulates the production of acute-phase proteins by hepatocytes as well as tissue inhibitor of metalloproteinases-1 (TIMP-1) production by fibroblasts in vitro. We have generated an adenovirus (Ad) encoding MuOSM and tested the effects of administration of recombinant AdMuOSM to mice in vivo. On intramuscular injection, AdMuOSM (5 X 10(7) plaque-forming units, pfu) induced an increase in serum levels of interleukin-6 …
Authors
Kerr C; Langdon C; Graham F; Gauldie J; Hara T; Richards CD
Journal
Journal of Interferon & Cytokine Research, Vol. 19, No. 10, pp. 1195–1205
Publisher
Mary Ann Liebert
Publication Date
10 1999
DOI
10.1089/107999099313145
ISSN
1079-9907