Journal article
Murine Oncostatin M Stimulates Mouse Synovial Fibroblasts in Vitro and Induces Inflammation and Destruction in Mouse Joints in Vivo
Abstract
Oncostatin M (OSM) is a multifunctional cytokine, a member of the interleukin-6/leukemia inhibitory factor (IL-6/LIF) family, that can regulate a number of connective-tissue cell types in vitro including cartilage and synovial tissue-derived fibroblasts, however its role in joint inflammation in vivo is not clear. We have analyzed murine OSM (muOSM) activity in vitro and in vivo in mouse joint tissue, to determine the potential role of this …
Authors
Langdon C; Kerr C; Hassen M; Hara T; Arsenault AL; Richards CD
Journal
American Journal Of Pathology, Vol. 157, No. 4, pp. 1187–1196
Publisher
Elsevier
Publication Date
October 2000
DOI
10.1016/s0002-9440(10)64634-2
ISSN
0002-9440