Drug Resistance, Neoplasm Concept

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• A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer  Journal Articles
• A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin  Journal Articles
• A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer  Journal Articles
• A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer  Journal Articles
• A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer  Journal Articles
• A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations  Journal Articles
• A combination of MSH2 DNA mismatch repair deficiency and expression of the SV40 large T antigen results in cisplatin resistance of mouse embryonic fibroblasts  Journal Articles
• A lentiviral vector‐based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma  Journal Articles
• A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia  Journal Articles
• A phase II study of AT9283, an aurora kinase inhibitor, in patients with relapsed or refractory multiple myeloma: NCIC clinical trials group IND.191  Journal Articles
• A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia  Journal Articles
• A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer  Journal Articles
• A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer  Journal Articles
• A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients  Journal Articles
• A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer  Journal Articles
• A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer  Journal Articles
• Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance  Journal Articles
• Adapting the Lung Cancer Symptom Scale (LCSS) to mesothelioma  Journal Articles
• Addressing Taxane Resistance in Metastatic Castration-Resistant Prostate Cancer: A Focus On Chaperone Proteins  Journal Articles
• Advanced Ovarian Cancer: Phase III Randomized Study of Sequential Cisplatin–Topotecan and Carboplatin–Paclitaxel vs Carboplatin–Paclitaxel  Journal Articles
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Journal Articles
• Alterations in Mitochondrial and Apoptosis‐regulating Gene Expression in Photodynamic Therapy‐resistant Variants of HT29 Colon Carcinoma Cells^¶  Journal Articles
• Belantamab mafodotin, pomalidomide, and dexamethasone for triple class exposed/refractory relapsed multiple myeloma: a subgroup analysis of the ALGONQUIN trial.  Journal Articles
• Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2  Journal Articles
• Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy  Journal Articles
• Canadian real-world experience of asciminib treatment in heavily pre-treated chronic myeloid leukemia (CML) patients who failed multiple lines of tyrosine kinase inhibitor (TKI) therapy  Journal Articles
• Cancer Gastric Chemoprevention: Isolation of Gastric Tumor-Initiating Cells  Journal Articles
• Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial  Journal Articles
• Case report of pneumatosis intestinalis secondary to sunitinib treatment for refractory gastrointestinal stromal tumor.  Journal Articles
• Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain  Journal Articles
• Chemosensitization of gemcitabine‐resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti‐apoptotic gene, clusterin  Journal Articles
• Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points.  Journal Articles
• Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity  Journal Articles
• Combined gamma‐irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin  Journal Articles
• Comparative Effectiveness of All Available Treatments for Metastatic Hormone-Sensitive Prostate Cancer: A Network Meta-analysis  Journal Articles
• Concurrent use of multiple low dose chemotherapy agents with differing mechanisms of action as a strategy vs passive resistance: A pilot study.  Journal Articles
• Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma  Journal Articles
• Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer  Journal Articles
• Dose-Ranging and Cohort-Expansion Study of Monalizumab (IPH2201) in Patients with Advanced Gynecologic Malignancies: A Trial of the Canadian Cancer Trials Group (CCTG): IND221  Journal Articles
• EXPRESSION OF MULTIDRUG RESISTANCE-RELATED PROTEIN (MRP-1), LUNG RESISTANCE-RELATED PROTEIN (LRP) AND TOPOISOMERASE-II (TOPO-II) IN WILMS' TUMOR: IMMUNOHISTOCHEMICAL STUDY USING TMA METHODOLOGY  Journal Articles
• Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer  Journal Articles
• Energetic characteristics of cisplatin resistant ovarian carcinoma cells.  Journal Articles
• Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline  Journal Articles
• Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia.  Journal Articles
• Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer  Journal Articles
• Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer  Journal Articles
• Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion  Journal Articles
• Functional role of BAALC in leukemogenesis  Journal Articles
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Journal Articles
• Gastrointestinal pharmacology: practical tips for the esophagologist  Journal Articles
• Gemcitabine, dexamethasone and cisplatin is an active andnon-toxic chemotherapy regimen in relapsed or refractory Hodgkin’s disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group  Journal Articles
• Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.  Journal Articles
• HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome  Journal Articles
• High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells  Journal Articles
• ID4: a new player in the cancer arena  Journal Articles
• IL‐25 promotes cisplatin resistance of lung cancer cells by activating NF‐κB signaling pathway to increase of major vault protein  Journal Articles
• Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors  Journal Articles
• Imaging, procedural and clinical variables associated with tumor yield on bone biopsy in metastatic castration-resistant prostate cancer  Journal Articles
• In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells  Journal Articles
• In vivo resistance to photofrin-mediated photodynamic therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated photodynamic therapy  Journal Articles
• Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design  Journal Articles
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Journal Articles
• Induction of Hsp60 by Photofrin-mediated photodynamic therapy  Journal Articles
• Influence of the proto-oncogene c-fos on cisplatin sensitivity  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature  Journal Articles
• Introduction to Cancer Stem Cells: Past, Present, and Future  Chapters
• Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells  Journal Articles
• Metformin—A Thought-provoking Addition to Anticancer Therapies—Reply  Journal Articles
• MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies  Journal Articles
• MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function  Journal Articles
• Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance.  Journal Articles
• Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy  Journal Articles
• Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression  Journal Articles
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Journal Articles
• NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer  Journal Articles
• Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents  Journal Articles
• New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities  Journal Articles
• Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases: a systematic review from the Cancer Care Ontario Program in Evidence-based Care's Genitourinary Cancer Disease Site Group  Journal Articles
• Novel targets and approaches in advanced prostate cancer  Journal Articles
• Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance  Journal Articles
• PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia  Journal Articles
• PLATYPUS: A Multiple-View Learning Predictive Framework for Cancer Drug Sensitivity Prediction.  Journal Articles
• Paclitaxel plus hydroxyurea as second line therapy for non-small cell lung cancer  Journal Articles
• Phase 2 study evaluating intermittent and continuous linsitinib and weekly paclitaxel in patients with recurrent platinum resistant ovarian epithelial cancer  Journal Articles
• Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218  Journal Articles
• Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours  Journal Articles
• Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I  Journal Articles
• Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance  Journal Articles
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross‐Resistance to UVA but not UVC Light  Journal Articles
• Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer  Journal Articles
• Polymorphisms and Clinical Outcome in Recurrent Ovarian Cancer Treated with Cyclophosphamide and Bevacizumab  Journal Articles
• Preclinical evaluation of a new liposomal formulation of cisplatin, lipoplatin, to treat cisplatin-resistant cervical cancer  Journal Articles
• Predicting response to EGFR-tyrosine kinase inhibitors among diverse ancestries: Just way too polymorphic  Journal Articles
• Promising response of dabrafenib, trametinib, and osimertinib combination therapy for concomitant BRAF and EGFR-TKI resistance mutations  Journal Articles
• Randomized Phase II Trial of Custirsen (OGX-011) in Combination with Docetaxel or Mitoxantrone as Second-line Therapy in Patients with Metastatic Castrate-Resistant Prostate Cancer Progressing after First-line Docetaxel: CUOG Trial P-06c  Journal Articles
• Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks  Journal Articles
• Role of the transcription factor Ets-1 in cisplatin resistance  Journal Articles
• SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells  Journal Articles
• Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available  Journal Articles
• Safety of enzalutamide in patients with metastatic castration‐resistant prostate cancer previously treated with docetaxel: Expanded access in North America  Journal Articles
• Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy  Journal Articles
• Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound  Journal Articles
• Stressproteine bei der Pathogenese des Prostatakarzinoms  Journal Articles
• Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis  Journal Articles
• Systemic Therapy in Men with Metastatic Castration-resistant Prostate Cancer: A Systematic Review  Journal Articles
• TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial  Journal Articles
• Targeting the Resistance of Pancreatic Cancer Cells to Nutrient Deprivation: Anti-Austerity Compounds  Journal Articles
• The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group  Journal Articles
• The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein  Journal Articles
• The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma  Journal Articles
• The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line.  Journal Articles
• The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models  Journal Articles
• The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation  Journal Articles
• Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial  Journal Articles
• Treatment of mCRPC in the AR-axis-targeted therapy-resistant state  Conferences
• Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy  Journal Articles
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Journal Articles
• USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation  Journal Articles
• USP2a alters chemotherapeutic response by modulating redox  Journal Articles
• Unmet needs in relapsed/refractory mantle cell lymphoma (r/r MCL) post-covalent Bruton tyrosine kinase inhibitor (BTKi): a systematic literature review and meta-analysis  Journal Articles
• Use of the Proton Pump Inhibitor Pantoprazole to Modify the Distribution and Activity of Doxorubicin: A Potential Strategy to Improve the Therapy of Solid Tumors  Journal Articles
• miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma  Journal Articles
• miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells  Journal Articles
• pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells  Journal Articles