Drug Resistance, Neoplasm Concept

subject area of

• A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours  Academic Article
• A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin  Academic Article
• A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer  Academic Article
• A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer  Academic Article
• A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations  Academic Article
• A combination of MSH2 DNA mismatch repair deficiency and expression of the SV40 large T antigen results in cisplatin resistance of mouse embryonic fibroblasts  Academic Article
• A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia  Academic Article
• A phase II study of AT9283, an aurora kinase inhibitor, in patients with relapsed or refractory multiple myeloma: NCIC clinical trials group IND.191  Academic Article
• A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia  Academic Article
• A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer  Academic Article
• A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer  Academic Article
• A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients  Academic Article
• A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer  Academic Article
• A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer  Academic Article
• Adapting the Lung Cancer Symptom Scale(LCSS) to mesothelioma  Academic Article
• Addressing taxane resistance in metastatic castration-resistant prostate cancer: a focus on chaperone proteins  Academic Article
• Adjuvant therapy for early breast cancer: where do we stand today?  Academic Article
• Advanced Ovarian Cancer: Phase III Randomized Study of Sequential Cisplatin–Topotecan and Carboplatin–Paclitaxel vs Carboplatin–Paclitaxel  Academic Article
• Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines  Academic Article
• Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶  Academic Article
• Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2  Academic Article
• Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines  Academic Article
• Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy  Academic Article
• Cancer Gastric Chemoprevention: Isolation of Gastric Tumor-Initiating Cells  Academic Article
• Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial  Academic Article
• Case report of pneumatosis intestinalis secondary to sunitinib treatment for refractory gastrointestinal stromal tumor.  Academic Article
• Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain  Academic Article
• Chemosensitization of gemcitabine-resistant human bladder cancer cell line bothin vitroandin vivousing antisense oligonucleotide targeting the anti-apoptotic gene, clusterin  Academic Article
• Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points.  Academic Article
• Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity  Academic Article
• Combined gamma‐irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin  Academic Article
• Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma  Academic Article
• Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer  Academic Article
• EXPRESSION OF MULTIDRUG RESISTANCE-RELATED PROTEIN (MRP-1), LUNG RESISTANCE-RELATED PROTEIN (LRP) AND TOPOISOMERASE-II (TOPO-II) IN WILMS' TUMOR: IMMUNOHISTOCHEMICAL STUDY USING TMA METHODOLOGY  Academic Article
• Energetic characteristics of cisplatin resistant ovarian carcinoma cells.  Academic Article
• Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline  Academic Article
• ErbB Receptor Signaling and Therapeutic Resistance to Aromatase Inhibitors  Conference Paper
• Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer  Academic Article
• Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer  Academic Article
• Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion  Academic Article
• Functional role of BAALC in leukemogenesis  Academic Article
• Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells  Academic Article
• Gastrointestinal pharmacology: practical tips for the esophagologist  Academic Article
• Gemcitabine, dexamethasone and cisplatin is an active andnon-toxic chemotherapy regimen in relapsed or refractory Hodgkin’s disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group  Academic Article
• HER2/neu in systemic therapy for women with breast cancer: a systematic review  Academic Article
• HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome  Academic Article
• High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells  Academic Article
• ID4: a new player in the cancer arena.  Academic Article
• IL‐25 promotes cisplatin resistance of lung cancer cells by activating NF‐κB signaling pathway to increase of major vault protein  Academic Article
• Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors  Academic Article
• Imaging, procedural and clinical variables associated with tumor yield on bone biopsy in metastatic castration-resistant prostate cancer  Academic Article
• Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation  Academic Article
• In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells  Academic Article
• In vivo resistance to photofrin-mediated photodynamic therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated photodynamic therapy  Academic Article
• Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design  Academic Article
• Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells  Academic Article
• Induction of Hsp60 by Photofrin-mediated photodynamic therapy  Academic Article
• Influence of the proto-oncogene c-fos on cisplatin sensitivity  Academic Article
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Academic Article
• Introduction to Cancer Stem Cells: Past, Present, and Future  Chapter
• Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells  Academic Article
• Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial  Academic Article
• Metformin—A Thought-provoking Addition to Anticancer Therapies—Reply  Academic Article
• MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies  Academic Article
• MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function  Academic Article
• Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance.  Academic Article
• Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy  Academic Article
• Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression  Academic Article
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Academic Article
• Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents  Academic Article
• New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities  Academic Article
• Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases: a systematic review from the Cancer Care Ontario Program in Evidence-based Care's Genitourinary Cancer Disease Site Group  Academic Article
• Novel targets and approaches in advanced prostate cancer  Academic Article
• Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance  Academic Article
• Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218  Academic Article
• Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance  Academic Article
• Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light  Academic Article
• Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer  Academic Article
• Predicting response to EGFR-tyrosine kinase inhibitors among diverse ancestries: Just way too polymorphic  Academic Article
• Randomized Phase II Trial of Custirsen (OGX-011) in Combination with Docetaxel or Mitoxantrone as Second-line Therapy in Patients with Metastatic Castrate-Resistant Prostate Cancer Progressing after First-line Docetaxel: CUOG Trial P-06c  Academic Article
• Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks  Academic Article
• Role of the transcription factor Ets-1 in cisplatin resistance  Academic Article
• SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells  Academic Article
• Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available  Academic Article
• Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial*  Academic Article
• Safety of enzalutamide in patients with metastatic castration‐resistant prostate cancer previously treated with docetaxel: Expanded access in North America  Academic Article
• Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement.  Academic Article
• Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy  Academic Article
• Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound  Academic Article
• Stressproteine bei der Pathogenese des Prostatakarzinoms  Academic Article
• Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis  Academic Article
• Systemic Therapy in Men with Metastatic Castration-resistant Prostate Cancer: A Systematic Review  Academic Article
• TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial  Academic Article
• Targeting the Resistance of Pancreatic Cancer Cells to Nutrient Deprivation: Anti-Austerity Compounds  Academic Article
• The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group  Academic Article
• The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein  Academic Article
• The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma  Academic Article
• The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line.  Academic Article
• The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation  Academic Article
• Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial  Academic Article
• Treatment of mCRPC in the AR-axis-targeted therapy-resistant state  Conference Paper
• Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy  Academic Article
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Academic Article
• USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation  Academic Article
• USP2a alters chemotherapeutic response by modulating redox  Academic Article
• miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma  Academic Article
• miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells  Academic Article
• pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells  Academic Article