Drug Resistance, Neoplasm
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A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours Academic Article
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A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin Academic Article
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A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer Academic Article
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A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer Academic Article
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A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations Academic Article
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A combination of MSH2 DNA mismatch repair deficiency and expression of the SV40 large T antigen results in cisplatin resistance of mouse embryonic fibroblasts Academic Article
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A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia Academic Article
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A phase II study of AT9283, an aurora kinase inhibitor, in patients with relapsed or refractory multiple myeloma: NCIC clinical trials group IND.191 Academic Article
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A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia Academic Article
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A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer Academic Article
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A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer Academic Article
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A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients Academic Article
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A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer Academic Article
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A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer Academic Article
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Adapting the Lung Cancer Symptom Scale(LCSS) to mesothelioma Academic Article
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Addressing taxane resistance in metastatic castration-resistant prostate cancer: a focus on chaperone proteins Academic Article
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Adjuvant therapy for early breast cancer: where do we stand today? Academic Article
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Advanced Ovarian Cancer: Phase III Randomized Study of Sequential Cisplatin–Topotecan and Carboplatin–Paclitaxel vs Carboplatin–Paclitaxel Academic Article
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Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines Academic Article
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Alterations in Mitochondrial and Apoptosis-regulating Gene Expression in Photodynamic Therapy-resistant Variants of HT29 Colon Carcinoma Cells¶ Academic Article
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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2 Academic Article
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Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines Academic Article
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Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy Academic Article
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Cancer Gastric Chemoprevention: Isolation of Gastric Tumor-Initiating Cells Academic Article
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Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial Academic Article
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Case report of pneumatosis intestinalis secondary to sunitinib treatment for refractory gastrointestinal stromal tumor. Academic Article
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Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain Academic Article
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Chemosensitization of gemcitabine-resistant human bladder cancer cell line bothin vitroandin vivousing antisense oligonucleotide targeting the anti-apoptotic gene, clusterin Academic Article
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Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. Academic Article
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Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity Academic Article
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Combined gamma‐irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin Academic Article
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Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma Academic Article
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Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer Academic Article
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EXPRESSION OF MULTIDRUG RESISTANCE-RELATED PROTEIN (MRP-1), LUNG RESISTANCE-RELATED PROTEIN (LRP) AND TOPOISOMERASE-II (TOPO-II) IN WILMS' TUMOR: IMMUNOHISTOCHEMICAL STUDY USING TMA METHODOLOGY Academic Article
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Energetic characteristics of cisplatin resistant ovarian carcinoma cells. Academic Article
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Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline Academic Article
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ErbB Receptor Signaling and Therapeutic Resistance to Aromatase Inhibitors Conference Paper
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Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer Academic Article
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Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer Academic Article
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Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion Academic Article
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Functional role of BAALC in leukemogenesis Academic Article
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Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells Academic Article
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Gastrointestinal pharmacology: practical tips for the esophagologist Academic Article
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Gemcitabine, dexamethasone and cisplatin is an active andnon-toxic chemotherapy regimen in relapsed or refractory Hodgkin’s disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group Academic Article
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HER2/neu in systemic therapy for women with breast cancer: a systematic review Academic Article
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HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome Academic Article
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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Academic Article
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ID4: a new player in the cancer arena. Academic Article
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IL‐25 promotes cisplatin resistance of lung cancer cells by activating NF‐κB signaling pathway to increase of major vault protein Academic Article
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Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors Academic Article
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Imaging, procedural and clinical variables associated with tumor yield on bone biopsy in metastatic castration-resistant prostate cancer Academic Article
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Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation Academic Article
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In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells Academic Article
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In vivo resistance to photofrin-mediated photodynamic therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated photodynamic therapy Academic Article
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Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design Academic Article
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Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells Academic Article
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Induction of Hsp60 by Photofrin-mediated photodynamic therapy Academic Article
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Influence of the proto-oncogene c-fos on cisplatin sensitivity Academic Article
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Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin Academic Article
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Introduction to Cancer Stem Cells: Past, Present, and Future Chapter
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Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells Academic Article
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Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial Academic Article
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Metformin—A Thought-provoking Addition to Anticancer Therapies—Reply Academic Article
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MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies Academic Article
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MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function Academic Article
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Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance. Academic Article
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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy Academic Article
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Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression Academic Article
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Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine Academic Article
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Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents Academic Article
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New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities Academic Article
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Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases: a systematic review from the Cancer Care Ontario Program in Evidence-based Care's Genitourinary Cancer Disease Site Group Academic Article
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Novel targets and approaches in advanced prostate cancer Academic Article
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Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance Academic Article
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Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218 Academic Article
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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance Academic Article
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Photodynamic Therapy Resistant Human Colon Carcinoma HT29 Cells Show Cross-Resistance to UVA but not UVC Light Academic Article
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Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer Academic Article
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Predicting response to EGFR-tyrosine kinase inhibitors among diverse ancestries: Just way too polymorphic Academic Article
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Randomized Phase II Trial of Custirsen (OGX-011) in Combination with Docetaxel or Mitoxantrone as Second-line Therapy in Patients with Metastatic Castrate-Resistant Prostate Cancer Progressing after First-line Docetaxel: CUOG Trial P-06c Academic Article
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Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks Academic Article
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Role of the transcription factor Ets-1 in cisplatin resistance Academic Article
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SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells Academic Article
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Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available Academic Article
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Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial* Academic Article
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Safety of enzalutamide in patients with metastatic castration‐resistant prostate cancer previously treated with docetaxel: Expanded access in North America Academic Article
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Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement. Academic Article
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Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy Academic Article
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Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound Academic Article
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Stressproteine bei der Pathogenese des Prostatakarzinoms Academic Article
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Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis Academic Article
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Systemic Therapy in Men with Metastatic Castration-resistant Prostate Cancer: A Systematic Review Academic Article
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TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial Academic Article
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Targeting the Resistance of Pancreatic Cancer Cells to Nutrient Deprivation: Anti-Austerity Compounds Academic Article
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The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group Academic Article
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The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein Academic Article
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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma Academic Article
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The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Academic Article
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The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation Academic Article
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Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial Academic Article
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Treatment of mCRPC in the AR-axis-targeted therapy-resistant state Conference Paper
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Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy Academic Article
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USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway Academic Article
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USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation Academic Article
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USP2a alters chemotherapeutic response by modulating redox Academic Article
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miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma Academic Article
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miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells Academic Article
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pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells Academic Article