Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer

BackgroundHuman breast cancer represents a significantly heterogeneous disease. Global gene expression profiling measurements have been used to classify tumors into multiple molecular subtypes. The capacity to define subtypes of breast tumors provides a framework to enable improved understanding of the mechanisms of breast oncogenesis, as well as to provide opportunities for improved therapeutic intervention in patients.MethodsWe used publicly …