Journal article
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Abstract
BackgroundProstate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast majority of patients. According to our oncogene-induced model for cancer development, senescence is a major tumor progression barrier. However, whether …
Authors
Mourkioti I; Polyzou A; Veroutis D; Theocharous G; Lagopati N; Gentile E; Stravokefalou V; Thanos D-F; Havaki S; Kletsas D
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 42, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13046-023-02769-z
ISSN
0392-9078