Journal article
In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells
Abstract
BackgroundEpilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistance proteins (MRPs) and P-gp are over-represented in brain tissue of patients with drug-resistant epilepsy, suggesting their involvement in the clearance of antiepileptic medications. In addition to their anticonvulsant action, …
Authors
Rizzo A; Donzelli S; Girgenti V; Sacconi A; Vasco C; Salmaggi A; Blandino G; Maschio M; Ciusani E
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 36, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s13046-017-0546-9
ISSN
0392-9078