Trials
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Overview
publication venue for
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Conditional versus non-conditional incentives to maximise return of participant completed questionnaires in clinical trials: a cluster randomised study within a trial
2023
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A new instrument to assess the credibility of effect modification analyses (ICEMAN) in randomized controlled trials and meta-analyses
2019
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Assessing differences in start-up between a pilot and main RCT in the ICU: The CYCLE international multicentre rehabilitation study
2019
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What proportion of ethically approved randomised clinical trials can be found in a trial registry?
2019
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Considerations in designing equity-relevant clinical trials
2017
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Mediation analysis to explore causal mechanisms in trials of complex interventions
2017
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On synthesis evidence from explanatory and pragmatic trials: a comparison of meta-analytic methods
2017
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Pilot and feasibility studies: a systematic review of studies conducted at the population health research institute
2017
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Statistical considerations for analyzing multiplex biomarker data from prospective studies
2017
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MATERNAL VITAMIN D SUPPLEMENTATION DURING PREGNANCY AND LACTATION TO PROMOTE INFANT GROWTH IN DHAKA, BANGLADESH (MDIG TRIAL): A RANDOMIZED CONTROLLED TRIAL
2017
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Defining feasibility and pilot studies in preparation for randomised controlled trials: using consensus methods and validation to develop a conceptual framework
2015
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EBRNetwork – a call to action for evidence-based research
2015
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Improving the reporting of randomised pilot and feasibility studies: a consort statement extension
2015
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Improving analysis of cognitive outcomes in cardiovascular trials using different statistical approaches..
25:644.
2024
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Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial..
25:619.
2024
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Reflections on the challenges of conducting an international multicentre randomized controlled trial of balance training in addition to pulmonary rehabilitation and its impact on fall incidence in people with COPD.
25:487.
2024
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Accounting for center-level effects in multicenter randomized controlled trials.
25:390.
2024
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Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial.
25:337.
2024
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Assessing fragility of statistically significant findings from randomized controlled trials assessing pharmacological therapies for opioid use disorders: a systematic review.
25:286.
2024
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Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18–24 months in very low birthweight infants?.
25:237.
2024
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The Diaphragmatic Initiated Ventilatory Assist (DIVA) trial: study protocol for a randomized controlled trial comparing rates of extubation failure in extremely premature infants undergoing extubation to non-invasive neurally adjusted ventilatory assist versus non-synchronized nasal intermittent positive pressure ventilation.
25:201.
2024
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REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial.
24:796.
2023
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Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants.
24:737.
2023
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Mobile phone text messaging plus motivational interviewing versus usual care: study protocol for a randomized controlled trial to evaluate effects on breastfeeding, child health, and survival outcomes, among women living with HIV (MTI-MI).
24:639.
2023
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Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan.
24:626.
2023
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Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial.
24:561.
2023
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Correction: Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial.
24:142.
2023
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Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for three randomized controlled trials and qualitative user-experience studies.
24:27.
2023
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Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial.
23:994.
2022
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A longitudinal assessment of trial protocols approved by research ethics committees: The Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study.
23:601.
2022
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Correction: Lessons learned from Integrated Management Program Advancing Community Treatment of Atrial Fibrillation (IMPACT-AF): a pragmatic clinical trial of computerized decision support in primary care.
23:547.
2022
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Effectiveness of the Shenzhuo formula in the treatment of patients with macroalbuminuria secondary to diabetic kidney disease: protocol update and statistical analysis plan.
23:61.
2022
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Intensity matters: protocol for a randomized controlled trial exercise intervention for individuals with chronic stroke.
23:442.
2022
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Prospective, randomized, controlled, double-blind, multi-center, multinational study on the safety and efficacy of 6% Hydroxyethyl starch (HES) sOlution versus an Electrolyte solutioN In patients undergoing eleCtive abdominal Surgery: study protocol for the PHOENICS study.
23:168.
2022
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Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery.
23:101.
2022
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Retention in RCTs of physical rehabilitation for adults with frailty: a systematic review and meta-analysis.
23:235.
2022
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The Mirasol Evaluation of Reduction in Infections Trial (MERIT): study protocol for a randomized controlled clinical trial.
23:257.
2022
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The Transitions to Long-term In Home Ventilator Engagement Study (Transitions to LIVE): study protocol for a pragmatic randomized controlled trial.
23:125.
2022
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Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial.
23:894.
2022
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A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol.
23:795.
2022
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A pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan.
23:772.
2022
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Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic.
23:735.
2022
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Lessons from the COVID-19 pandemic and recent developments on the communication of clinical trials, publishing practices, and research integrity: in conversation with Dr. David Moher.
23:671.
2022
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Efficacy of the cognitive functional therapy (CFT) in patients with chronic nonspecific low back pain: a study protocol for a randomized sham-controlled trial..
23:544.
2022
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Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments.
23:62.
2022
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A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
22:694.
2021
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A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
22:412.
2021
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A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®.
22:724.
2021
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Advancing collaborations in health research and clinical trials in Sub-Saharan Africa: development and implementation of a biostatistical collaboration module in the Masters in Biostatistics Program at Stellenbosch University.
22:478.
2021
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Combination of first-line chemotherapy with Kanglaite injections versus first-line chemotherapy alone for advanced non-small-cell lung cancer: study protocol for an investigator-initiated, multicenter, open-label, randomized controlled trial.
22:214.
2021
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Comparison of efficacy of a 7-day versus a 14-day course of intravenous antibiotics in the treatment of uncomplicated neonatal bacterial sepsis: study protocol of a randomized controlled non-inferiority trial.
22:859.
2021
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Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials.
22:708.
2021
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Deprescribing to reduce polypharmacy: study protocol for a randomised controlled trial assessing deprescribing of anticholinergic and sedative drugs in a cohort of frail older people living in the community.
22:766.
2021
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Exploring reasons for recruitment failure in clinical trials: a qualitative study with clinical trial stakeholders in Switzerland, Germany, and Canada.
22:844.
2021
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Feasibility study protocol of a pragmatic, randomised controlled pilot trial: membrane sweeping to prevent post-term pregnancy—the MILO Study.
22:113.
2021
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Lessons learned from Integrated Management Program Advancing Community Treatment of Atrial Fibrillation (IMPACT-AF): a pragmatic clinical trial of computerized decision support in primary care.
22:531.
2021
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PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial.
22:776.
2021
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Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY): a multi-center randomized controlled study comparing alternative antibiotic regimens in patients undergoing tumor resections with endoprosthetic replacements—a statistical analysis plan.
22:223.
2021
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Recruitment patterns in a large international randomized controlled trial of perioperative care in cancer patients.
22:219.
2021
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Simple compared to covariate-constrained randomization methods in balancing baseline characteristics: a case study of randomly allocating 72 hemodialysis centers in a cluster trial.
22:626.
2021
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Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy.
22:612.
2021
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Team approach to polypharmacy evaluation and reduction: study protocol for a randomized controlled trial.
22:746.
2021
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The Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program: protocol for a two-arm parallel partially nested randomized controlled feasibility trial with progression to full-scale trial.
22:856.
2021
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The intranasal dexmedetomidine plus ketamine for procedural sedation in children, adaptive randomized controlled non-inferiority multicenter trial (Ketodex): a statistical analysis plan.
22:15.
2021
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Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.
22:323.
2021
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A brief transdiagnostic psychological intervention for Afghan asylum seekers and refugees in Austria: a randomized controlled trial.
21:57.
2020
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A call for consensus in defining efficacy in clinical trials for opioid addiction: combined results from a systematic review and qualitative study in patients receiving pharmacological assisted therapy for opioid use disorder.
21:30.
2020
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A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards.
21:92.
2020
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A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial.
21:771.
2020
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Aim2Be mHealth intervention for children with overweight and obesity: study protocol for a randomized controlled trial.
21:132.
2020
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Analysis and reporting of stratified cluster randomized trials—a systematic survey.
21:930.
2020
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COVID-19 randomised trial protocols: rapid publication without barriers.
21:327.
2020
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Cluster identification, selection, and description in cluster randomized crossover trials: the PREP-IT trials.
21:712.
2020
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Comparison of four COVID-19 screening strategies to facilitate early case identification within the homeless shelter population: A structured summary of a study protocol for a randomised controlled trial.
21:941.
2020
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Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials.
21:821.
2020
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Developing and testing the effectiveness of a novel online integrated treatment for problem gambling and tobacco smoking: a protocol for an open-label randomized controlled trial.
21:937.
2020
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Development of a Core Outcome Set for Studies on Cardiac Disease in Pregnancy (COSCarP): a study protocol.
21:300.
2020
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Digital tools for trial recruitment and retention—plenty of tools but rigorous evaluation is in short supply.
21:476.
2020
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Health TAPESTRY Ontario: protocol for a randomized controlled trial to test reproducibility and implementation.
21:714.
2020
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Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial.
21:42.
2020
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Non-steroidal or opioid analgesia use for children with musculoskeletal injuries (the No OUCH study): statistical analysis plan.
21:759.
2020
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Normalization of a conversation tool to promote shared decision making about anticoagulation in patients with atrial fibrillation within a practical randomized trial of its effectiveness: a cross-sectional study.
21:395.
2020
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Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine.
21:299.
2020
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Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial.
21:592.
2020
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Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)—rationale and design for an international collaborative study.
21:731.
2020
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Quantitative response of healthy muscle following the induction of capsaicin: an exploratory randomized controlled trial.
21:1020.
2020
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Rationale and design of repeated cross-sectional studies to evaluate the reporting quality of trial protocols: the Adherence to SPIrit REcommendations (ASPIRE) study and associated projects.
21:896.
2020
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Reporting of key methodological and ethical aspects of cluster trials in hemodialysis require improvement: a systematic review.
21:752.
2020
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Retaining participants in community-based health research: a case example on standardized planning and reporting.
21:393.
2020
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Sahaj Samadhi Meditation versus a Health Enhancement Program for depression in chronic pain: protocol for a randomized controlled trial and implementation evaluation.
21:319.
2020
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Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study).
21:540.
2020
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Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed.
21:33.
2020
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The BEACON study: protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario.
21:925.
2020
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A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial.
20:319.
2019
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Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study.
20:800.
2019
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Correction to: Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial.
20:595.
2019
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Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.
20:606.
2019
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Design and rationale for a pragmatic cluster randomized trial of the Cardiovascular Health Awareness Program (CHAP) for social housing residents in Ontario and Quebec, Canada.
20:760.
2019
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Development of the IRIS-AR strategy: an intervention to improve rates of accrual and retention for the VTE-PRO randomized controlled trial.
20:447.
2019
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Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT).
20:161.
2019
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Multimorbidity risk assessment in adolescents and adults with cerebral palsy: a protocol for establishing a core outcome set for clinical research and practice.
20:176.
2019
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Population health intervention research: the place of theories.
20:285.
2019
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Population health intervention research: what is the place for pilot studies?.
20:309.
2019
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.
20:532.
2019
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Protocol for a randomised controlled trial to evaluate the effectiveness of improving tuberculosis patients’ treatment adherence via electronic monitors and an app versus usual care in Tibet.
20:273.
2019
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Rationale and methods of an Evaluation of the Effectiveness of the Community Paramedicine at Home (CP@home) program for frequent users of emergency medical services in multiple Ontario regions: a study protocol for a randomized controlled trial.
20:75.
2019
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Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols.
20:572.
2019
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The effects of two early parenting interventions on child aggression and risk for violence in Brazil (The PIÁ Trial): protocol for a randomised controlled trial.
20:253.
2019
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What happens to intimate partner violence studies registered on clinicaltrials.gov? A systematic review of a clinical trials registry.
20:288.
2019
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Who says “no” to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program.
20:313.
2019
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Zwakala Ndoda: a cluster and individually randomized trial aimed at improving testing, linkage, and adherence to treatment for hard-to reach men in KwaZulu-Natal, South Africa.
20:798.
2019
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Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.
20:587.
2019
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7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.
19:111.
2018
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A cluster randomised trial of a classroom communication resource program to change peer attitudes towards children who stutter among grade 7 students.
19:664.
2018
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Chinese herbal medicine Shenzhuo Formula treatment in patients with macroalbuminuria secondary to diabetic kidney disease: study protocol for a randomized controlled trial.
19:200.
2018
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DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.
19:606.
2018
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Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients (COSSOPP): a study protocol.
19:655.
2018
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Exploring factors associated with views on sharing of certain interim trial result measures by the data safety monitoring board (DSMB) with non-DSMB members.
19:621.
2018
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FIT for FUNCTION: study protocol for a randomized controlled trial.
19:39.
2018
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Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan.
19:588.
2018
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Identifying trial recruitment uncertainties using a James Lind Alliance Priority Setting Partnership – the PRioRiTy (Prioritising Recruitment in Randomised Trials) study.
19:147.
2018
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Outcome Measures in Rheumatology - Interventions for medication Adherence (OMERACT-Adherence) Core Domain Set for Trials of Interventions for Medication Adherence in Rheumatology: 5 Phase Study Protocol.
19:204.
2018
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Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial.
19:688.
2018
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Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial.
19:83.
2018
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Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study).
19:636.
2018
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Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.
19:182.
2018
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Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial.
19:691.
2018
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Survey of professional views on sharing interim results by the Data Safety Monitoring Board (DSMB): what to share, with whom and why.
19:281.
2018
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The Classroom Communication Resource (CCR) intervention to change peer’s attitudes towards children who stutter (CWS): study protocol for a randomised controlled trial.
19:43.
2018
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The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel drugs.
19:505.
2018
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Using acute tryptophan depletion to investigate predictors of treatment response in adolescents with major depressive disorder: study protocol for a randomised controlled trial.
19:434.
2018
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Barriers and facilitators to healthcare professional behaviour change in clinical trials using the Theoretical Domains Framework: a case study of a trial of individualized temperature-reduced haemodialysis.
18:227.
2017
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Challenges to complete and useful data sharing.
18:71.
2017
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Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial.
18:526.
2017
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Feasibility of a Systematic, Comprehensive, One-to-One Training (SCOOT) program for new scooter users: study protocol for a randomized control trial.
18:235.
2017
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Interactive weekly mobile phone text messaging plus motivational interviewing in promotion of breastfeeding among women living with HIV in South Africa: study protocol for a randomized controlled trial.
18:331.
2017
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Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial.
18:293.
2017
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Nitrous oxide (N2O) and subsequent open-label SSRI treatment of adolescents with depression (NOTAD): study protocol for a randomised controlled trial.
18:617.
2017
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Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry.
18:610.
2017
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Sharing interim trial results by the Data Safety Monitoring Board with those responsible for the trial’s conduct and progress: a narrative review.
18:120.
2017
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The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial.
18:55.
2017
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The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials.
18:12.
2017
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The effectiveness of a Supported Self-management task-shifting intervention for adult depression in Vietnam communities: study protocol for a randomized controlled trial.
18:209.
2017
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A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial.
17:110.
2016
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A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial.
17:556.
2016
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Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study.
17:310.
2016
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Cost-effective recruitment methods for a large randomised trial in people with diabetes: A Study of Cardiovascular Events iN Diabetes (ASCEND).
17:286.
2016
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Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials.
17:369.
2016
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Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial.
17:261.
2016
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Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial.
17:377.
2016
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Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.
17:238.
2016
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The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial.
17:512.
2016
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The ethics of future trials: qualitative analysis of physicians’ decision making.
17:12.
2016
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Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial.
16:173.
2015
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Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study.
16:355.
2015
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Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial.
16:462.
2015
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Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension.
16:302.
2015
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Effectiveness of pharmaceutical care at discharge in the emergency department: study protocol of a randomized controlled trial.
16:60.
2015
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Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial.
16:245.
2015
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Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies.
16:351.
2015
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Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial.
16:300.
2015
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Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial.
16:448.
2015
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Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria.
16:475.
2015
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Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial.
16:185.
2015
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Reducing the confusion and controversies around pragmatic trials: using the Cardiovascular Health Awareness Program (CHAP) trial as an illustrative example.
16:387.
2015
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Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan.
16:459.
2015
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Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial.
16:214.
2015
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Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.
16:95.
2015
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Virtual colonoscopy, optical colonoscopy, or fecal occult blood testing for colorectal cancer screening: results of a pilot randomized controlled trial.
16:296.
2015
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Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users: study protocol for a randomized controlled trial.
16:164-164.
2015
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A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial.
15:268.
2014
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Accounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes.
15:377.
2014
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Building clinical trial priorities at the University of Rwanda.
15:467.
2014
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Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial.
15:3.
2014
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Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial.
15:258.
2014
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Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial.
15:257.
2014
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Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial.
15:502.
2014
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Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial.
15:222.
2014
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Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial.
15:170.
2014
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Implementing evidence-based recommended practices for the management of patients with mild traumatic brain injuries in Australian emergency care departments: study protocol for a cluster randomised controlled trial.
15:281.
2014
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Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial.
15:393.
2014
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SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients.
15:339.
2014
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Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT).
15:72.
2014
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Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study.
15:206.
2014
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Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol.
15:33-33.
2014
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Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening.
14:40.
2013
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Definition and reporting of pilot and feasibility studies.
14:o18.
2013
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Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial.
14:346-346.
2013
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Feasibility of the Enhancing Participation In the Community by improving Wheelchair Skills (EPIC Wheels) program: study protocol for a randomized controlled trial.
14:350-350.
2013
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HIV prevention in favour of the choice-disabled in southern Africa: study protocol for a randomised controlled trial.
14:274-274.
2013
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Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design.
14:335-335.
2013
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Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial.
14:441-441.
2013
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Allocation techniques for balance at baseline in cluster randomized trials: a methodological review.
13:120.
2012
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Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial.
13:52.
2012
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Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience.
13:5.
2012
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Rapid, easy, and cheap randomization: prospective evaluation in a study cohort.
13:90.
2012
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Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial.
13:153.
2012
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A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial.
12:70.
2011
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A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol.
12:69.
2011
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Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group.
12:48.
2011
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Does clinical equipoise apply to cluster randomized trials in health research?.
12:118.
2011
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Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial.
12:192.
2011
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Ethical issues posed by cluster randomized trials in health research.
12:100.
2011
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Individual participant data meta-analyses compared with meta-analyses based on aggregate data.
12:a57.
2011
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Investigator experiences with financial conflicts of interest in clinical trials.
12:9.
2011
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The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy.
12:5.
2011
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The challenges and opportunities of conducting a clinical trial in a low resource setting: The case of the Cameroon mobile phone SMS (CAMPS) trial, an investigator initiated trial.
12:145.
2011
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The impact of clinical data on the evaluation of tibial fracture healing.
12:237.
2011
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When is informed consent required in cluster randomized trials in health research?.
12:202.
2011
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Who is the research subject in cluster randomized trials in health research?.
12:183.
2011
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Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer - a randomized controlled trial.
11:81.
2010
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Design, analysis, and presentation of crossover trials.
10:27.
2009
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Ethical and policy issues in cluster randomized trials: rationale and design of a mixed methods research study.
10:61.
2009
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Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison.
10:86.
2009
-
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
10:87.
2009
-
Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial.
10:81.
2009
-
LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact.
10:40-40.
2009
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Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2).
10:49-49.
2009
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Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials.
10:101-101.
2009
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Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies.
9:62.
2008
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Reporting of noninferiority and equivalence randomized trials for major prostaglandins: A systematic survey of the ophthalmology literature.
9:69.
2008
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What constitutes a "clinical trial"?: A survey of oncology professionals.
9:12.
2008
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Dose response of ACE inhibitors: implications of the SECURE trial.
2:155-159.
2001
has subject area
Identity
International Standard Serial Number (ISSN)
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0250-6807
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1468-6708
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1745-6215
Electronic International Standard Serial Number (EISSN)