Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial Journal Articles uri icon

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  • Abstract Background Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis. Methods LOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800). Eligible patients have sepsis as the diagnosis for admission to the intensive care unit (ICU) and are receiving vasopressors. Those admitted to the ICU for more than 24 h are excluded. Eligible patients are randomized to high-dose intravenous vitamin C (50 mg/kg every 6 h for 96 h) or placebo. The primary outcome is a composite of death or persistent organ dysfunction (need for vasopressors, invasive mechanical ventilation, or new and persisting renal replacement therapy) at day 28. Secondary outcomes include persistent organ dysfunction-free days to day 28, mortality and health-related quality of life at 6 months, biomarkers of dysoxia, inflammation, infection, endothelial function, and adverse effects (hemolysis, acute kidney injury, and hypoglycemia). Six subgroup analyses are planned. Discussion This RCT will provide evidence of the effect of high-dose intravenous vitamin C on patient-important outcomes in patients with sepsis. Trial registration clinicaltrials.gov, NCT03680274, first posted 21 September 2018.


  • Masse, Marie-Hélène
  • Ménard, Julie
  • Sprague, Sheila Ann
  • Battista, Marie-Claude
  • Cook, Deborah
  • Guyatt, Gordon
  • Heyland, Daren K
  • Kanji, Salmaan
  • Pinto, Ruxandra
  • Day, Andrew G
  • Cohen, Dian
  • Annane, Djillali
  • McGuinness, Shay
  • Parke, Rachael
  • Carr, Anitra
  • Arabi, Yaseen
  • Vijayaraghavan, Bharath Kumar Tirupakuzhi
  • D’Aragon, Frédérick
  • Carbonneau, Élaine
  • Maslove, David
  • Hunt, Miranda
  • Rochwerg, Bram
  • Millen, Tina
  • Chassé, Michaël
  • Lebrasseur, Martine
  • Archambault, Patrick
  • Deblois, Estel
  • Drouin, Christine
  • Lellouche, François
  • Lizotte, Patricia
  • Watpool, Irene
  • Porteous, Rebecca
  • Clarke, France
  • Marinoff, Nicole
  • Belley-Cote, Emilie
  • Bolduc, Brigitte
  • Walker, Scott
  • Iazzetta, John
  • Adhikari, Neill KJ
  • Lamontagne, François

publication date

  • December 2020

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