Journal article
Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants
Abstract
BackgroundExtremely preterm infants have a high mortality and morbidity. Here, we present a statistical analysis plan for secondary Bayesian analyses of the pragmatic, sufficiently powered multinational, trial—SafeBoosC III—evaluating the benefits and harms of cerebral oximetry monitoring plus a treatment guideline versus usual care for such infants.MethodsThe SafeBoosC-III trial is an investigator-initiated, open-label, randomised, …
Authors
Olsen MH; Hansen ML; Lange T; Gluud C; Thabane L; Greisen G; Jakobsen JC
Journal
Trials, Vol. 24, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13063-023-07720-3
ISSN
1468-6708