Interleukin-5 Concept

subject area of

• A novel microbe-based treatment that attenuates the inflammatory profile in a mouse model of allergic airway disease  Journal Articles
• Allergen-Induced Increase in Airway Responsiveness, Airway Eosinophilia, and Bone-Marrow Eosinophil Progenitors in Mice  Journal Articles
• Allergen-induced Increases in Bone Marrow T Lymphocytes and Interleukin-5 Expression in Subjects with Asthma  Journal Articles
• Allergen‐induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34⁺ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation  Journal Articles
• Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35  Journal Articles
• Anti-allergic therapies: effects on eosinophil progenitors  Journal Articles
• Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma  Journal Articles
• Anti–IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics  Journal Articles
• Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti–IL-5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial  Journal Articles
• Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma  Journal Articles
• Bone marrow contribution to eosinophilic inflammation  Conferences
• Bone marrow in atopy and asthma: hematopoietic mechanisms in allergic inflammation  Journal Articles
• CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors  Journal Articles
• Cigarette Smoke Differentially Affects Eosinophilia and Remodeling in a Model of House Dust Mite Asthma  Journal Articles
• Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.  Journal Articles
• Clinical significance of measuring levels of sputum and serum ECP and serum IL‐5 in bronchial asthma  Conferences
• Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation  Journal Articles
• Cord blood molecular biomarkers of eosinophilopoiesis: Kinetic analysis of GATA-1, MBP1 and IL-5Rα mRNA expression  Journal Articles
• Costimulation Through CD86 Is Involved in Airway Antigen-Presenting Cell and T Cell Responses to Allergen in Atopic Asthmatics  Journal Articles
• Cytokines or Their Antagonists for the Treatment of Asthma  Journal Articles
• Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study  Journal Articles
• Differences in Functional Consequences and Signal Transduction Induced by IL-3, IL-5, and Nerve Growth Factor in Human Basophils  Journal Articles
• Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.  Journal Articles
• Early Intestinal Th1 Inflammation and Mucosal T Cell Recruitment During Acute Graft-Versus-Host Reaction  Journal Articles
• Effect of anti‐IL‐5 biologics on weight and body mass index  Journal Articles
• Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis  Journal Articles
• Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response  Journal Articles
• Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma  Journal Articles
• Enhanced Expression of GM-CSF in Differentiating Eosinophils of Atopic and Atopic Asthmatic Subjects  Journal Articles
• Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor α  Journal Articles
• Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis  Journal Articles
• Evaluation of Inducible Costimulator/B7-Related Protein-1 as a Therapeutic Target in a Murine Model of Allergic Airway Inflammation  Journal Articles
• Evaluation of peroxisome proliferator‐activated receptor agonists on interleukin‐5‐induced eosinophil differentiation  Journal Articles
• Exacerbations of Severe Asthma While on Anti–IL-5 Biologics  Journal Articles
• Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.  Journal Articles
• Fish Oil Supplementation in Pregnancy Modifies Neonatal Progenitors at Birth in Infants at Risk of Atopy  Journal Articles
• GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.  Journal Articles
• Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation  Journal Articles
• Generation of experimental allergic airways inflammation in the absence of draining lymph nodes  Journal Articles
• Granulocyte Macrophage Colony–Stimulating Factor–Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4  Journal Articles
• Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures  Journal Articles
• Haemopoietic mechanisms in murine allergic upper and lower airway inflammation  Journal Articles
• Haemopoietic processes in allergic disease: eosinophil/basophil development  Journal Articles
• IL-5 contributes to worm expulsion and muscle hypercontractility in a primaryT. spiralisinfection  Journal Articles
• IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease  Journal Articles
• Increased detection of interleukin-;5 in sputum by addition of protease inhibitors  Journal Articles
• Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice  Journal Articles
• Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects.  Journal Articles
• Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia  Journal Articles
• Increased production of IL-5 and dominant Th2-type response in airways of Churg–Strauss syndrome patients  Journal Articles
• Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics  Journal Articles
• Interactions of Hemopoietic Cytokines on Differentiation of HL-60 Cells  Journal Articles
• Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4–Deficient Mice  Journal Articles
• Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors  Journal Articles
• Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects  Journal Articles
• Interleukin‐4 and RANTES expression in maturing eosinophils derived from human cord blood CD34⁺ progenitors  Journal Articles
• Interleukin‐5 and allergic inflammation  Journal Articles
• Interleukin‐5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections  Journal Articles
• Interleukin‐8 is a chemo‐attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects  Journal Articles
• Intrinsic pathway of apoptosis in peripheral blood eosinophils of Churg–Strauss syndrome  Journal Articles
• Kinetics of Allergen-Induced Airway Eosinophilic Cytokine Production and Airway Inflammation  Journal Articles
• Kinetics of Bone Marrow Eosinophilopoiesis and Associated Cytokines after Allergen Inhalation  Journal Articles
• Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia  Journal Articles
• Modulation of Human Airway Smooth Muscle Migration by Lipid Mediators and Th-2 Cytokines  Journal Articles
• Monoclonal antibodies for the treatment of refractory asthma  Journal Articles
• Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4  Journal Articles
• New treatment approaches for asthma  Journal Articles
• Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma  Journal Articles
• Novel targeted therapies for eosinophilic disorders  Journal Articles
• POINT: Will New Anti-eosinophilic Drugs Be Useful in Asthma Management? Yes  Journal Articles
• Pathogenesis of Murine Experimental Allergic Rhinitis: A Study of Local and Systemic Consequences of IL-5 Deficiency  Journal Articles
• Proliferation and release of IL-5 and IFN-γ by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non–cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1  Journal Articles
• Reassessing the Th2 cytokine basis of asthma  Journal Articles
• Recombinant adenovirus vectors expressing interleukin‐5 and ‐6 specifically enhance mucosal immunoglobulin A responses in the lung  Journal Articles
• Reduced amount of intestinal mucus by treatment with anti‐CD4 antibody interferes with the spontaneous cure of Nippostrongylus brasiliensis‐infection in mice  Journal Articles
• Regulation of IL–5 and IL–5 Receptor Expression in the Bone Marrow of Allergic Asthmatics  Conferences
• Relationship between Sputum Eosinophilia and Sinus Disease in Patients with Eosinophilic Bronchitis  Journal Articles
• Reslizumab for Poorly Controlled, Eosinophilic Asthma  Journal Articles
• Sputum CD34⁺IL-5Rα⁺ Cells Increase after Allergen  Journal Articles
• Sputum cytokines associated with raised FeNO after anti‐IL5 biologic therapy in severe asthma  Journal Articles
• Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena  Journal Articles
• Systemic aspects of allergic disease: the role of the bone marrow  Journal Articles
• The Demise of Anti–IL-5 for Asthma, or Not  Journal Articles
• The Effect of Pranlukast on Allergen-induced Bone Marrow Eosinophilopoiesis in Subjects with Asthma  Journal Articles
• The Effects of Intranasal Budesonide on Allergen-induced Production of Interleukin-5 and Eotaxin, Airways, Blood, and Bone Marrow Eosinophilia, and Eosinophil Progenitor Expansion in Sensitized Mice  Journal Articles
• The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice  Journal Articles
• The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin‐5 deficiency  Journal Articles
• The trials and tribulations of IL-5, eosinophils, and allergic asthma  Journal Articles
• The trials and tribulations of anti–IL-5 …  Journal Articles
• Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma  Journal Articles
• Toll‐like receptor‐mediated eosinophil–basophil differentiation: autocrine signalling by granulocyte–macrophage colony‐stimulating factor in cord blood haematopoietic progenitors  Journal Articles
• Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice  Journal Articles