Journal article
Anti–IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
Abstract
BACKGROUND: Eosinophils develop from CD34(+) progenitors under the influence of IL-5. Atopic asthmatic individuals have increased numbers of mature eosinophils and eosinophil pro-genitors within their bone marrow and bronchial mucosa. We have previously reported that anti-IL-5 monoclonal antibody treatment decreases total bone marrow and bronchial mucosal eosinophil numbers in asthma.
OBJECTIVE: Using an anti-IL-5 monoclonal antibody, we …
Authors
Menzies-Gow A; Flood-Page P; Sehmi R; Burman J; Hamid Q; Robinson DS; Kay AB; Denburg J
Journal
Journal of Allergy and Clinical Immunology, Vol. 111, No. 4, pp. 714–719
Publisher
Elsevier
Publication Date
April 2003
DOI
10.1067/mai.2003.1382
ISSN
0091-6749