Journal article
Increased production of IL-5 and dominant Th2-type response in airways of Churg–Strauss syndrome patients
Abstract
OBJECTIVE: Churg-Strauss syndrome (CSS) is a rare systemic vasculitis associated with eosinophilia and asthma. We assessed the local immune response in airways of CSS patients with different activity of the disease.
METHODS: Concentration of IL-5, CCL17, CCL22 and CCL26 (ELISA) together with cell expression of T-helper-related genes (real-time PCR array) were measured in bronchoalveolar lavage fluid (BALF) sampled from 11 patients with active …
Authors
Jakiela B; Szczeklik W; Plutecka H; Sokolowska B; Mastalerz L; Sanak M; Bazan-Socha S; Szczeklik A; Musial J
Journal
Rheumatology, Vol. 51, No. 10, pp. 1887–1893
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 2012
DOI
10.1093/rheumatology/kes171
ISSN
1462-0324