Journal article
Cigarette Smoke Differentially Affects Eosinophilia and Remodeling in a Model of House Dust Mite Asthma
Abstract
Although a similar prevalence of smoking is evident among patients with asthma and the general population, little is known about the impact of cigarette smoke on the immune inflammatory processes elicited by common environmental allergens. We investigated the impact of exposure to cigarette smoke on house dust mite (HDM)-induced allergic airway inflammation and its consequences for tissue remodeling and lung physiology in mice. BALB/c mice …
Authors
Botelho FM; Llop-Guevara A; Trimble NJ; Nikota JK; Bauer CMT; Lambert KN; Kianpour S; Jordana M; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 45, No. 4, pp. 753–760
Publisher
American Thoracic Society
Publication Date
October 2011
DOI
10.1165/rcmb.2010-0404oc
ISSN
1044-1549
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Airway RemodelingAirway ResistanceAllergensAnimalsAsthmaB-LymphocytesBronchial HyperreactivityChemokine CCL11Dendritic CellsDisease Models, AnimalFemaleInterleukin-13Interleukin-5LungMiceMice, Inbred BALB CPulmonary EosinophiliaPyroglyphidaeSmokingT-LymphocytesTime FactorsTransforming Growth Factor betaVascular Cell Adhesion Molecule-1