Journal article
Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma
Abstract
BACKGROUND: Thymic stromal lymphopoietin (TSLP) and IL-33 are considered important initiators of type 2 immunity. In asthmatic patients allergic inflammatory responses are associated with increased lung homing of bone marrow-derived CD34(+) hematopoietic progenitor cells (HPCs), which include eosinophil lineage-committed progenitor cells. In this study we investigated the role of TSLP and IL-33 in the recruitment of progenitor cells to the …
Authors
Smith SG; Gugilla A; Mukherjee M; Merim K; Irshad A; Tang W; Kinoshita T; Watson B; Oliveria J-P; Comeau M
Journal
Journal of Allergy and Clinical Immunology, Vol. 135, No. 6, pp. 1594–1602
Publisher
Elsevier
Publication Date
June 2015
DOI
10.1016/j.jaci.2014.12.1918
ISSN
0091-6749
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, InhalationAdultAllergensAsthmaCell MovementChemokine CXCL12CytokinesEosinophilsForced Expiratory VolumeGene Expression RegulationHematopoietic Stem CellsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-13Interleukin-13 Receptor alpha1 SubunitInterleukin-33Interleukin-5Interleukin-7 Receptor alpha SubunitInterleukinsMaleMethacholine ChlorideMiddle AgedPrimary Cell CultureReceptors, Cell SurfaceReceptors, CytokineSputumThymic Stromal Lymphopoietin