Journal article
Sputum CD34+IL-5Rα+ Cells Increase after Allergen
Abstract
Eosinophil lineage-committed progenitors increase in the bone marrow of subjects with asthma developing allergen-induced airway hyperresponsiveness and eosinophilia. Also, higher numbers of circulating eosinophil/basophil cfu have been demonstrated 24 hours after allergen inhalation and in bronchial and nasal biopsies of allergic individuals. These cells may undergo in situ eosinophilopoiesis, suggesting that after allergen inhalation, …
Authors
Dorman SC; Efthimiadis A; Babirad I; Watson RM; Denburg JA; Hargreave FE; O'Byrne PM; Sehmi R
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 169, No. 5, pp. 573–577
Publisher
American Thoracic Society
Publication Date
March 1, 2004
DOI
10.1164/rccm.200307-1004oc
ISSN
1073-449X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AllergensAnalysis of VarianceAntigens, CD34AsthmaBronchial Provocation TestsBronchoconstrictor AgentsCase-Control StudiesEosinophilsFlow CytometryForced Expiratory VolumeHematopoiesisHematopoietic Stem CellsHumansHypersensitivity, ImmediateInterleukin-5Leukocyte CountMethacholine ChloridePulmonary EosinophiliaRespiratory HypersensitivitySputumTime Factors