selected scholarly activity
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chapters
- Animal Models of Kidney Disease. 379-417. 2017
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conferences
- Augmented myogenic constriction in the SHR pre-glomerular renal arteries protects the kidneys from elevated blood pressure. The FASEB Journal. 2018
- Effect Of Allergen Challenge On Inflammation Induced By Toll-Like Receptor Stimulation In A Nasal Challenge Model. American Journal of Respiratory and Critical Care Medicine. 2015
- Ire1 Mediated Xbp1 Splicing Is Critical For Pulmonary Fibroblast Proliferation And Differentiation. American Journal of Respiratory and Critical Care Medicine. 2015
- Fkbp13 Deficiency Leads To Increased Pulmonary Er Stress, Inflammation And Fibrosis After Bleomycin Administration. American Journal of Respiratory and Critical Care Medicine. 2014
- Grp78 Heterozygosity Abrogates Bleomycin-Induced Lung Fibrosis By Modulating Er-Resident Protein Folding Capacity. American Journal of Respiratory and Critical Care Medicine. 2014
- 4-phenylbutyrate protects against angiotensin II/DOCA salt-induced hypertension in a C57BL/6 mouse model of chronic kidney disease. The FASEB Journal. 2013
- ER stress and a chronic inflammatory response are induced in an Angiotensin II/DOCA salt model of chronic kidney disease.. The FASEB Journal. 2013
- The HDAC inhibitor, vorinastat, prevents TGF-beta 1 induced EMT and apoptosis in human renal proximal tubular cells. The FASEB Journal. 2013
- 4-Phenylbutyrate Prevents Upr Activation And Myofibroblast Differentiation In Experimental Bleomycin-Induced Lung Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2013
- Grp78 Heterozygosity Protects Against Bleomycin-Induced Lung Fibrosis And Inflammation. American Journal of Respiratory and Critical Care Medicine. 2013
- Determining how 4‐phenylbutyrate inhibits tunicamycininduced acute kidney injury. The FASEB Journal. 2012
- Hypertension induces proteinuria and renal fibrosis associated with endoplasmic reticulum (ER) stress in the Dahl salt sensitive rat. The FASEB Journal. 2012
- TDAG51 overexpression mediates proximal tubule epithelial cell apoptosis through its accumulation in the nucleus. The FASEB Journal. 2012
- ER stress inducing agents that cause induction of TDAG51 and epithelial adhesion disruption result in epithelial to mesenchymal transition via β‐catenin signaling. The FASEB Journal. 2011
- Loss of TDAG51 attenuates aorta smooth muscle to osteoblast trans-differentiation and calcification. The FASEB Journal. 2011
- The gene TDAG51 facilitates the phosphorylation of eIF2α in mouse embryonic fibroblasts. The FASEB Journal. 2011
- The small molecule chemical chaperone 4‐Phenylbutyrate inhibits epithelial‐to‐mesenchymal transition in human renal proximal tubular epithelial cells. The FASEB Journal. 2011
- Intracellular localization of TDAG51 modulates its effect on cell death. The FASEB Journal. 2009
- Macrophage Differentiation Involves Activation of the Unfolded Protein Response. The FASEB Journal. 2008
- Contributions of Endoplasmic Reticulum (ER) Stress to Cardiovascular Disease. CURRENT ADVANCES IN HEART DISEASE. 57-58. 2008
- TDAG51 Deficiency Promotes Migration and Proliferation of Mouse Embryonic Fibroblasts.. Blood. 3941-3941. 2006
- Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells. The FASEB Journal. A765-A765. 2004
- Calcium, nitric oxide (NO) and superoxide responses of outer medullary vasa recta to angiotensin II (AII). The FASEB Journal. A851-A851. 2002
- Vasopressin Increases Intracellular NO Concentration via Ca 2+ Signaling in Inner Medullary Collecting Duct. Hypertension. 465-469. 2002
- Buffering of AVP hypertensive action by Ca2+ mediated nitric oxide production in inner medullary collecting duct.. Hypertension. 476-476. 2001
- Glomerular insufficiency limits clearance in Dahl salt sensitive rats.. The FASEB Journal. A448-A448. 2001
- Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension. 456-461. 2001
- Confocal image reconstruction reveals reduced glomerular capillary lumen volume associated with lower GFR in DS rats.. The FASEB Journal. A133-A133. 2000
- Three-dimensional image reconstruction of medullary blood supply in normotensive volume expanded rats. Journal of Hypertension. S28-S28. 2000
- Apoptosis in the muscular arteries from young spontaneously hypertensive rats. Journal of Hypertension. S66-S66. 1998
- Hyperplasia of medial smooth muscle cells is not responsible for vascular hypertrophy in hypertension. Journal of Hypertension. S108-S108. 1998
- Decreased incidence of apoptosis in the mesenteric arteries from spontaneously hypertensive rats. Journal of Vascular Research. 8-8. 1998
- Hyperplasia of medial smooth muscle cells is not involved in vascular hypertrophy in hypertension. Journal of Vascular Research. 21-21. 1998
- STRUCTURE AND FUNCTIONAL-ANALYSIS OF SMALL MUSCULAR ARTERIES FROM PRE-HYPERTENSIVE SHR AND WKY RATS. The FASEB Journal. A560-A560. 1995
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journal articles
- Renal Medulla in Hypertension.. Hypertension. 2024
- Follistatin lowers blood pressure and improves vascular structure and function in essential and secondary hypertension.. Hypertension Research. 1-15. 2024
- Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity. Kidney360. 3:1394-1410. 2022
- TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease. Cell Death and Disease. 12:921. 2021
- Inhibition of histone deacetylation with vorinostat does not prevent tunicamycin-mediated acute kidney injury. PLoS ONE. 16:e0260519-e0260519. 2021
- Enhanced Myogenic Constriction in the SHR Preglomerular Vessels Is Mediated by Thromboxane A2 Synthesis. Frontiers in Physiology. 11:853. 2020
- Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat. American Journal of Physiology. Heart and Circulatory Physiology. 316:H1214-H1223. 2019
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IL ‐6 mediatesER expansion during hyperpolarization of alternatively activated macrophages. Immunology and Cell Biology. 97:203-217. 2019 - Protein misfolding in endoplasmic reticulum stress with applications to renal diseases. Advances in Protein Chemistry and Structural Biology. 118:217-247. 2019
- Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation. Biochemical and Biophysical Research Communications. 486:163-170. 2017
- Vascular structural and functional changes: their association with causality in hypertension: models, remodeling and relevance. Hypertension Research. 40:311-323. 2017
- Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria. Scientific Reports. 7:41572. 2017
- Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. American Journal of Physiology - Renal Physiology. 312:F230-F244. 2017
- Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function. Journal of Hypertension. 34:1556-1569. 2016
- GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. Journal of Pathology. 239:411-425. 2016
- Alterations to the middle cerebral artery of the hypertensive-arthritic rat model potentiates intracerebral hemorrhage. PeerJ. 4:e2608-e2608. 2016
- Major comorbid disease processes associated with increased incidence of acute kidney injury. World Journal of Nephrology. 5:139-139. 2016
- Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.. Journal of Biological Chemistry. 290:28725-28725. 2015
- SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology. 26:1839-1854. 2015
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis. International Journal of Biochemistry and Cell Biology. 61:45-52. 2015
- Acute Kidney Injury: Preclinical Innovations, Challenges, and Opportunities for Translation. Canadian Journal of Kidney Health and Disease. 2:62-62. 2015
- Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease. Journal of Immunology Research. 2015:1-10. 2015
- Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD. BioMed Research International. 2015:1-10. 2015
- 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression. PLoS ONE. 9:e84663-e84663. 2014
- Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis. Circulation. 127:2523-2534. 2013
- Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin‐1 Expression. Journal of the American Heart Association. 2:e000134. 2013
- Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest. 143:1098-1105. 2013
- TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium. American Journal of Physiology - Renal Physiology. 303:F467-F481. 2012
- ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death. American Journal of Physiology - Renal Physiology. 303:F266-F278. 2012
- Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase. Journal of Biological Chemistry. 287:7603-7614. 2012
- Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease. Circulation Research. 108:629-642. 2011
- Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions. The FASEB Journal. 25:576-589. 2011
- α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells. Nature Communications. 2:307. 2011
- Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores. Journal of Biological Chemistry. 285:28912-28923. 2010
- Development of a continuous assay for the measurement of tissue factor procoagulant activity on intact cells. Laboratory Investigation. 90:953-962. 2010
- Endoplasmic Reticulum Stress and Renal Disease. Antioxidants and Redox Signaling. 11:2341-2352. 2009
- The methylenetetrahydrofolate reductase C677T mutation induces cell‐specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site‐specific cancer risk modification. International Journal of Cancer. 124:1999-2005. 2009
- Macrophage Function and Its Impact on Atherosclerotic Lesion Composition, Progression, and Stability. Arteriosclerosis, Thrombosis and Vascular Biology. 28:1413-1415. 2008
- Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. The FASEB Journal. 22:2569-2578. 2008
- Role of Endoplasmic Reticulum Calcium Disequilibria in the Mechanism of Homocysteine-Induced ER Stress. Antioxidants and Redox Signaling. 9:1863-1874. 2007
- Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome. Circulation. 116:1214-1216. 2007
- Proteasomal Regulation of Cardiac Hypertrophy. Circulation. 114:1796-1798. 2006
- Peroxynitrite Causes Endoplasmic Reticulum Stress and Apoptosis in Human Vascular Endothelium. Arteriosclerosis, Thrombosis and Vascular Biology. 25:2623-2629. 2005
- TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia. Journal of Biological Chemistry. 278:30317-30327. 2003
- Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity. Journal of Biological Chemistry. 278:17438-17447. 2003
- Tubulovascular Nitric Oxide Crosstalk. Circulation Research. 91:487-493. 2002
- Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct.. Hypertension. 39:465-469. 2002
- Brown Norway Chromosome 13 Confers Protection From High Salt to Consomic Dahl S Rat. Hypertension. 37:456-461. 2001
- Increased medial smooth muscle cell length is responsible for vascular hypertrophy in young hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology. 279:H2085-H2094. 2000
- Apoptosis in the muscular arteries from young spontaneously hypertensive rats. Journal of Hypertension. 17:1413-1419. 1999
- Blood pressure and heart rate development in young spontaneously hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology. 274:H794-H800. 1998
- Blood pressure and heart rate development in young spontaneously hypertensive rats. American Journal of Physiology. 274:H794-H800. 1998
- Structural and Functional Analysis of Small Arteries From Young Spontaneously Hypertensive Rats. Hypertension. 29:781-789. 1997