Journal article
Inhibition of histone deacetylation with vorinostat does not prevent tunicamycin-mediated acute kidney injury
Abstract
Endoplasmic reticulum (ER) stress is associated with acute kidney injury (AKI) caused by various mechanisms, including antibiotics, non-steroidal anti-inflammatory drugs, cisplatin, and radiocontrast. Tunicamycin (TM) is a nucleoside antibiotic that induces ER stress and is a commonly used model of AKI. 4-phenylbutyrate (4-PBA) is a chemical chaperone and histone deacetylase (HDAC) inhibitor and has been shown to protect the kidney from ER …
Authors
Carlisle RE; Farooqi S; Zhang MC; Liu S; Lu C; Phan A; Brimble E; Dickhout JG
Journal
PLOS ONE, Vol. 16, No. 11,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0260519
ISSN
1932-6203