Journal article
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice
Abstract
A causal relationship between diet-induced hyperhomocysteinemia (HHcy) and accelerated atherosclerosis has been established in apolipoprotein E-deficient (apoE(-/-)) mice. However, it is not known whether the proatherogenic effect of HHcy in apoE(-/-) mice is independent of hyperlipidemia and/or deficiency of apoE. In this study, a comprehensive dietary approach using C57BL/6J mice was used to investigate whether HHcy is an independent risk …
Authors
Zhou J; Werstuck GH; Lhotak Š; Shi YY; Tedesco V; Trigatti B; Dickhout J; Majors AK; DiBello PM; Jacobsen DW
Journal
The FASEB Journal, Vol. 22, No. 7, pp. 2569–2578
Publisher
Wiley
Publication Date
July 2008
DOI
10.1096/fj.07-105353
ISSN
0892-6638