Hypertension induces proteinuria and renal fibrosis associated with endoplasmic reticulum (ER) stress in the Dahl salt sensitive rat

Hypertension and proteinuria are associated with the progression of chronic kidney disease (CKD). CKD occurs via a process of kidney fibrosis and nephron loss. The Dahl salt sensitive hypertensive rat (Dahl SS) is a model of hypertension caused by high salt, resulting in proteinuria and CKD. We hypothesized that hypertension‐induced proteinuria in the Dahl SS leads to renal fibrosis through the initiation of ER stress and the unfolded protein …