Tobias Berg
Associate Professor, Oncology

My research interests are focused around understanding determinants of treatment response in AML and to develop novel treatments based on this understanding. I am trained as hematologist and medical oncologist. During my doctoral thesis and postdoctoral fellowship, I also received training in molecular and cellular biology.

I have been using functional model systems both in vitro and in vivo to study the role of epigenetic regulators in this context and their interplay with lineage-specific differentiation and more classical transcriptional regulators. We are also studying biological processes that happen in residual cells after treatment and that could explain why AML unfortunately often relapses after treatment. This effort will be based on the combined use of our previous expertise in identifying measurable residual disease (MRD) in AML based on flow-cytometric techniques and the application of functional assays and novel single cell resolution methods to characterize residual AML cells during, and shortly after, chemotherapy in patients and surrogate xenograft models.

As a clinician scientist, I am actively involved in the clinical treatment of patients with hematological malignancies at the Juravinski Cancer Centre. My focus is in the fields of hematopoietic stem cell transplantation and early clinical trials. Allogeneic stem cell transplantation (transplantation with cells from related or unrelated donors) represents a platform technology for curing otherwise incurable hematological malignancies including leukemias that are at a high-risk for relapse. We plan to use MRD-guided interventions and combine the use of allogeneic stem cell transplantation with targeted therapies. With my background in early clinical trials, collaboration with others is a key component of my program so as to facilitate the translation of our findings into novel treatments.
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