Conference
Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model
Abstract
Abstract
The histone methyl-transferase EZH2 is frequently affected by gain-of-function mutations in germinal-center lymphoma. To further test if these EZH2 mutations can be driver mutations in lymphomagenesis, we have previously generated and characterized a mouse line transgenic for EZH2Y641F. This mouse model leads to an acceleration of lymphoma development in combination with Myc. We have now further investigated this …
Authors
Berg T; Thoene S; Yap D; Wee T; Schoeler N; Rosten P; Lim E; Bilenky M; Mungall AJ; Oellerich T
Volume
122
Publisher
American Society of Hematology
Publication Date
November 15, 2013
DOI
10.1182/blood.v122.21.346.346
Conference proceedings
Blood
Issue
21
ISSN
0006-4971