Journal article
LSD1 Inhibition Enhances Antigen Presentation and Co-Stimulation in AML to Promote T Cell-Mediated Anti-Leukemia Immune Responses
Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can provide a curative treatment option for acute myeloid leukemia (AML). Donor T cells play an important role in the curative potential of allo-HSCT by recognizing and eliminating residual leukemic cells, inducing the desirable graft-versus-leukemia (GVL) effect. Evading from this effect of donor T cell immune surveillance through the downregulation of human leukocyte antigen class …
Authors
Yan Y; Singh K; Hartung E; Lee B; Prabagaran P; Khalaf D; Garcia-Horton A; Leber B; Walker I; Lepic KL
Journal
Blood, Vol. 142, No. Supplement 1,
Publisher
American Society of Hematology
Publication Date
November 2, 2023
DOI
10.1182/blood-2023-188472
ISSN
0006-4971