Conference
Induction of G1 Arrest and Apoptosis in a Conditional Expression Model of AML1/ETO: P53-Independent Upregulation of P21/WAF/CIP1.
Abstract
Abstract
Background: The translocation (8;21) is the most common chromosomal rearrangement in AML, resulting in the expression of the fusion protein AML1/ETO. We have developed an ecdysone-inducible U937 model, in which AML1/ETO is expressed in response to treatment with Ponasterone (Pon) A (Fliegauf et al, Oncogene 2004). This model system was used to determine the cellular effects of AML1/ETO and to identify its target genes …
Authors
Berg T; Fliegauf M; Pitako J; Burger J; Abdelkarim M; Guo Y; Staege MS; Burdach S; Lübbert M
Volume
104
Publisher
American Society of Hematology
Publication Date
November 16, 2004
DOI
10.1182/blood.v104.11.2576.2576
Conference proceedings
Blood
Issue
11
ISSN
0006-4971