Protein C Concept

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2 DIFFERENT MISSENSE MUTATIONS AT ARG 178 OF THE PROTEIN-C (PROC) GENE CAUSING RECURRENT VENOUS THROMBOSIS Journal Articles
A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function Journal Articles
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care Journal Articles
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation Journal Articles
A549 Lung Epithelial Cells Synthesize Anticoagulant Molecules on the Cell Surface and Matrix and in Conditioned Media Journal Articles
Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus Journal Articles
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging Journal Articles
Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes Journal Articles
Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation Journal Articles
Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium Journal Articles
Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. Journal Articles
Activated protein C in sepsis and beyond: Update 2006 Journal Articles
Activated protein C resistance, factor V Leiden and peripheral vascular disease. Journal Articles
Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes Journal Articles
Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells Journal Articles
Advances in Antithrombotic Therapy: Novel Agents Journal Articles
Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis Journal Articles
Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency Journal Articles
Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy Journal Articles
Comparison of N-linked glycosylation of protein C in newborns and adults Journal Articles
Continuing Challenges of Sepsis Research Journal Articles
Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va Journal Articles
Diagnostic and prognostic accuracy of Protein C in adult patients with sepsis: protocol for a systematic review and meta-analysis Journal Articles
Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis Journal Articles
Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin Conferences
Does activated protein C resistance increase the risk of systemic embolism in non rheumatic atrial fibrillation? Journal Articles
Dose–response study of recombinant human soluble thrombomodulin (ART‐123) in the prevention of venous thromboembolism after total hip replacement Journal Articles
Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death. Journal Articles
Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis? Journal Articles
Drotrecogin alfa (activated): down and not out, but not really in either. Journal Articles
Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor Journal Articles
Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia Journal Articles
Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway Journal Articles
Endogenous protein C activation in patients with severe sepsis Journal Articles
Evidence of a Founder Effect for the Protein C Gene 3363 Inserted C Mutation in Thrombophilic Pedigrees of French Origin Journal Articles
Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex Journal Articles
Final Results of the RHAPSODY Trial: A Multi‐Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A‐APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke Journal Articles
Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II: P1 Arg Is Required for Maximal Thrombin Inhibition Journal Articles
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Journal Articles
Glycosaminoglycans Bind Factor Xa in a Ca²⁺-Dependent Fashion and Modulate Its Catalytic Activity Journal Articles
Heparin‐induced thrombocytopenia and thrombosis: clinical and laboratory studies Journal Articles
Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor Journal Articles
Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients Journal Articles
In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity Journal Articles
Inherited Thrombophilia in Ischemic Stroke and Its Pathogenic Subtypes Journal Articles
Low Plasma Protein C Values Predict Mortality in Low Birth Weight Neonates With Septicemia Journal Articles
Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function Journal Articles
Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis Journal Articles
Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant Journal Articles
NMR Structures Reveal How Oxidation Inactivates Thrombomodulin Journal Articles
New Anticoagulants Journal Articles
New anticoagulants Conferences
No Association Between Protein C Levels and Bacteremia in Children With Febrile Neutropenia Journal Articles
Patients with severe sepsis vary markedly in their ability to generate activated protein C Journal Articles
Problems of stopping trials early Journal Articles
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis Journal Articles
Protective effects of activated protein C in sepsis Journal Articles
Protein C Assay Performance Journal Articles
Protein C deficiency and thromboembolism: recurrent mutation at Arg 306 in the protein C gene Journal Articles
Should adult patients be routinely tested for heritable thrombophilia after an episode of venous thromboembolism? Journal Articles
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 Journal Articles
THE EFFECTS OF DNASE I AND LOW-MOLECULAR-WEIGHT HEPARIN IN A MURINE MODEL OF POLYMICROBIAL ABDOMINAL SEPSIS Journal Articles
Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism Journal Articles
The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia Journal Articles
The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal‐based and cell‐based models Journal Articles
The impact of the endothelial protein C receptor on thrombin generation and clot lysis Journal Articles
The plasma concentration of activated protein C appears normal in patients with haemophilia Journal Articles
The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis Journal Articles
Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation. Journal Articles
Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events Journal Articles
Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma Journal Articles
Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis Journal Articles
Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels. Journal Articles
Zinc: An important cofactor in haemostasis and thrombosis Journal Articles