Protein C Concept

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A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function Academic Article
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care Academic Article
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation Academic Article
A549 Lung Epithelial Cells Synthesize Anticoagulant Molecules on the Cell Surface and Matrix and in Conditioned Media Academic Article
Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus Academic Article
Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes Academic Article
Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation Academic Article
Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium Academic Article
Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. Academic Article
Activated protein C in sepsis and beyond: Update 2006 Academic Article
Activated protein C resistance, factor V Leiden and peripheral vascular disease. Academic Article
Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes Academic Article
Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells Academic Article
Advances in Antithrombotic Therapy: Novel Agents Academic Article
Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis Academic Article
Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency Academic Article
Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy Academic Article
Comparison of N-linked glycosylation of protein C in newborns and adults Academic Article
Continuing Challenges of Sepsis Research Academic Article
Conversion of thrombin into an anticoagulant by protein engineering Academic Article
Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va Academic Article
Diagnostic and prognostic accuracy of Protein C in adult patients with sepsis: protocol for a systematic review and meta-analysis Academic Article
Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis Academic Article
Differential Gene Expression in Thrombomodulin (TM; CD141)+ and TM− Dendritic Cell Subsets Academic Article
Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin Conference Paper
Dissociation of Thrombin's Substrate Interactions Using Site-Directed Mutagenesis Academic Article
Does activated protein C resistance increase the risk of systemic embolism in non rheumatic atrial fibrillation? Academic Article
Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement Academic Article
Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death. Academic Article
Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis? Academic Article
Drotrecogin alfa (activated): down and not out, but not really in either. Academic Article
Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor Academic Article
Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia Academic Article
Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway Academic Article
Endogenous protein C activation in patients with severe sepsis Academic Article
Evidence of a Founder Effect for the Protein C Gene 3363 Inserted C Mutation in Thrombophilic Pedigrees of French Origin Academic Article
Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex Academic Article
Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ Academic Article
Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II: P1 Arg Is Required for Maximal Thrombin Inhibition Academic Article
Functional Mapping of the Surface Residues of Human Thrombin Academic Article
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Academic Article
Glycosaminoglycans Bind Factor Xa in a Ca2+-Dependent Fashion and Modulate Its Catalytic Activity Academic Article
Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies Academic Article
Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor Academic Article
Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients Academic Article
In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity Academic Article
Inherited Thrombophilia in Ischemic Stroke and Its Pathogenic Subtypes Academic Article
Low Plasma Protein C Values Predict Mortality in Low Birth Weight Neonates With Septicemia Academic Article
Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function Academic Article
Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant Academic Article
Modulation of Thrombin’s Procoagulant and Anticoagulant Properties Conference Paper
NMR Structures Reveal How Oxidation Inactivates Thrombomodulin Academic Article
New Anticoagulants Academic Article
New anticoagulants Conference Paper
No Association Between Protein C Levels and Bacteremia in Children With Febrile Neutropenia Academic Article
Patients with severe sepsis vary markedly in their ability to generate activated protein C Academic Article
Problems of stopping trials early Academic Article
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis Academic Article
Protective effects of activated protein C in sepsis Academic Article
Protein C Assay Performance Academic Article
Protein C deficiency and thromboembolism: recurrent mutation at Arg 306 in the protein C gene Academic Article
Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activity in Vivo Academic Article
Should adult patients be routinely tested for heritable thrombophilia after an episode of venous thromboembolism? Academic Article
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 Academic Article
Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism Academic Article
The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia Academic Article
The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models Academic Article
The impact of the endothelial protein C receptor on thrombin generation and clot lysis Academic Article
The plasma concentration of activated protein C appears normal in patients with haemophilia Academic Article
Thrombin Interacts with Thrombomodulin, Protein C, and Thrombin-activatable Fibrinolysis Inhibitor via Specific and Distinct Domains Academic Article
Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation. Academic Article
Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events Academic Article
Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma Academic Article
Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis Academic Article
Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels. Academic Article
Zinc: An important cofactor in haemostasis and thrombosis Academic Article