Protein C Concept

subject area of

• A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function  Academic Article
• A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care  Academic Article
• A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation  Academic Article
• A549 Lung Epithelial Cells Synthesize Anticoagulant Molecules on the Cell Surface and Matrix and in Conditioned Media  Academic Article
• Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus  Academic Article
• Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging  Academic Article
• Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes  Academic Article
• Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation  Academic Article
• Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium  Academic Article
• Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat.  Academic Article
• Activated protein C in sepsis and beyond: Update 2006  Academic Article
• Activated protein C resistance, factor V Leiden and peripheral vascular disease.  Academic Article
• Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes  Academic Article
• Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells  Academic Article
• Advances in Antithrombotic Therapy: Novel Agents  Academic Article
• Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis  Academic Article
• Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency  Academic Article
• Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy  Academic Article
• Comparison of N-linked glycosylation of protein C in newborns and adults  Academic Article
• Continuing Challenges of Sepsis Research  Academic Article
• Conversion of thrombin into an anticoagulant by protein engineering  Academic Article
• Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va  Academic Article
• Diagnostic and prognostic accuracy of Protein C in adult patients with sepsis: protocol for a systematic review and meta-analysis  Academic Article
• Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis  Academic Article
• Differential Gene Expression in Thrombomodulin (TM; CD141)+ and TM− Dendritic Cell Subsets  Academic Article
• Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin  Conference Paper
• Dissociation of Thrombin's Substrate Interactions Using Site-Directed Mutagenesis  Academic Article
• Does activated protein C resistance increase the risk of systemic embolism in non rheumatic atrial fibrillation?  Academic Article
• Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement  Academic Article
• Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death.  Academic Article
• Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?  Academic Article
• Drotrecogin alfa (activated): down and not out, but not really in either.  Academic Article
• Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor  Academic Article
• Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia  Academic Article
• Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway  Academic Article
• Endogenous protein C activation in patients with severe sepsis  Academic Article
• Evidence of a Founder Effect for the Protein C Gene 3363 Inserted C Mutation in Thrombophilic Pedigrees of French Origin  Academic Article
• Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex  Academic Article
• Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ  Academic Article
• Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II:  P1 Arg Is Required for Maximal Thrombin Inhibition  Academic Article
• Functional Mapping of the Surface Residues of Human Thrombin  Academic Article
• Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition  Academic Article
• Glycosaminoglycans Bind Factor Xa in a Ca²⁺-Dependent Fashion and Modulate Its Catalytic Activity  Academic Article
• Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies  Academic Article
• Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor  Academic Article
• Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients  Academic Article
• In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity  Academic Article
• Inherited Thrombophilia in Ischemic Stroke and Its Pathogenic Subtypes  Academic Article
• Low Plasma Protein C Values Predict Mortality in Low Birth Weight Neonates With Septicemia  Academic Article
• Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function  Academic Article
• Modulation of Monocyte Function by Activated Protein C, a Natural Anticoagulant  Academic Article
• Modulation of Thrombin’s Procoagulant and Anticoagulant Properties  Conference Paper
• NMR Structures Reveal How Oxidation Inactivates Thrombomodulin  Academic Article
• New Anticoagulants  Academic Article
• New anticoagulants  Conference Paper
• No Association Between Protein C Levels and Bacteremia in Children With Febrile Neutropenia  Academic Article
• Patients with severe sepsis vary markedly in their ability to generate activated protein C  Academic Article
• Problems of stopping trials early  Academic Article
• Prognostic utility and characterization of cell-free DNA in patients with severe sepsis  Academic Article
• Protective effects of activated protein C in sepsis  Academic Article
• Protein C Assay Performance  Academic Article
• Protein C deficiency and thromboembolism: recurrent mutation at Arg 306 in the protein C gene  Academic Article
• Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activity in Vivo  Academic Article
• Should adult patients be routinely tested for heritable thrombophilia after an episode of venous thromboembolism?  Academic Article
• Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008  Academic Article
• Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism  Academic Article
• The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia  Academic Article
• The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models  Academic Article
• The impact of the endothelial protein C receptor on thrombin generation and clot lysis  Academic Article
• The plasma concentration of activated protein C appears normal in patients with haemophilia  Academic Article
• The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis  Academic Article
• Thrombin Interacts with Thrombomodulin, Protein C, and Thrombin-activatable Fibrinolysis Inhibitor via Specific and Distinct Domains  Academic Article
• Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation.  Academic Article
• Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events  Academic Article
• Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma  Academic Article
• Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis  Academic Article
• Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels.  Academic Article
• Zinc: An important cofactor in haemostasis and thrombosis  Academic Article