Journal article
Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium
Abstract
Activated protein C (APC) generation strongly affects sepsis and thrombosis by inhibition of thrombin generation. However, it is unclear if there are age-related differences in effectiveness of protein C (PC). We studied age effects on plasma APC generation +/- endothelium. Defibrinated (Ancrod) plasma (from adults or newborns (umbilical cord)) was recalcified with buffer containing tissue factor +/- thrombomodulin (TM) on either plastic or …
Authors
Chan AKC; Patel S; Male C; Berry LR; Mitchell LG
Journal
Thrombosis and Haemostasis, Vol. 91, No. 02, pp. 238–247
Publisher
Thieme
Publication Date
2004
DOI
10.1160/th03-06-0372
ISSN
0340-6245