Journal article
Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia
Abstract
Purpose: Activated protein C (APC) is the first anti-inflammatory drug to be approved for the treatment of severe sepsis. However, the underlying mechanisms are not completely elucidated. Therefore, the aim of our study was to evaluate the effects of APC on the microcirculation (mesenteric leukocyte-endothelial interaction, plasma extravasation) using intravital microscopy (IVM) and on cytokine release during experimental endotoxemia in …
Authors
Lehmann C; Scheibe R; Schade M; Meissner K; Gründling M; Usichenko T; Wendt M; Hung O; Whynot S; Murphy M
Journal
Journal canadien d'anesthésie, Vol. 55, No. 3, pp. 155–162
Publisher
Springer Nature
Publication Date
March 2008
DOI
10.1007/bf03016089
ISSN
0832-610X