Journal article
Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor
Abstract
Protein C in its activated form (APC) limits thrombin generation. Protein C inhibitor (PCI) readily neutralizes APC. Heparin accelerates this reaction, which may complicate anticoagulant treatment in patients with varying APC generation potential. A potent anticoagulant conjugate of antithrombin and heparin (ATH) was prepared, and its effect on APC+PCI reactions was tested. Second order rate constants for APC+PCI reactions were measured by …
Authors
Van Walderveen MC; Berry LR; Chan AKC
Journal
The Journal of Biochemistry, Vol. 148, No. 2, pp. 255–260
Publisher
Oxford University Press (OUP)
Publication Date
August 1, 2010
DOI
10.1093/jb/mvq060
ISSN
0021-924X