Comparison of N-linked glycosylation of protein C in newborns and adults

Protein C (PC) is a major anticoagulant that stems the propagation of thrombin. The activated form of PC (APC), in association with the cofactor protein S, proteolytically converts activated coagulation factors VIIIa and Va into inactive forms. Studies have shown that forms of PC that contain 3N-linked glycans (beta-PC) are functionally distinct from the fully glycosylated 4-glycan type (alpha-PC). Since some findings have also hinted at …