Interleukin-12 Concept

subject area of

• 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis  Journal Articles
• A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice AgainstLeishmania majorInfection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice  Journal Articles
• A pilot, open‐label, 8‐week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression  Journal Articles
• A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model  Journal Articles
• ANTI-INTERLEUKIN-12 THERAPY PROTECTS MICE IN LETHAL ENDOTOXEMIA BUT IMPAIRS BACTERIAL CLEARANCE IN MURINE ESCHERICHIA COLI PERITONEAL SEPSIS  Journal Articles
• Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models  Journal Articles
• Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors  Journal Articles
• Autologous lymphocyte responses to adenovirus-B7-1-transduced human cancer cells  Journal Articles
• Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required for host defense against viral infections  Journal Articles
• Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required.  Journal Articles
• Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance  Journal Articles
• Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity  Journal Articles
• Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells  Journal Articles
• Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy  Journal Articles
• Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12  Journal Articles
• Culture of myeloid dendritic cells from bone marrow precursors  Journal Articles
• Dendritic Cell-Derived IL-12 Is Not Required for the Generation of Cytotoxic, IFN-γ-Secreting, CD8+ CTL In Vivo  Journal Articles
• Dendritic cells expressing TGFβ/IL-10, and CHO cells with OX-2, increase graft survival  Journal Articles
• Different profiles of T-cell IFN-γ and IL-12 in allergen-induced early and dual responders with asthma  Journal Articles
• Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity  Journal Articles
• Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12  Journal Articles
• Effect of alginate on innate immune activation of macrophages  Journal Articles
• Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response  Journal Articles
• Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn’s Disease: Systematic Review and Meta-Analysis  Journal Articles
• Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)  Journal Articles
• Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration  Journal Articles
• Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene  Journal Articles
• FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice  Journal Articles
• Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines.  Journal Articles
• HIV-1 alters T helper cytokines, interleukin-12 and interleukin-18 responses to the protozoan parasite Leishmania donovani  Journal Articles
• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy  Journal Articles
• Human milk composition differs in healthy mothers and mothers with celiac disease  Journal Articles
• IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.  Journal Articles
• IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice  Journal Articles
• IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes  Journal Articles
• IL-15 has innate anti-tumor activity independent of NK and CD8 T cells  Journal Articles
• IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation  Journal Articles
• IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion  Journal Articles
• IL‐12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure  Journal Articles
• Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis  Journal Articles
• Impaired ability of burn patient neutrophils to stimulate β‐defensin production by keratinocytes  Journal Articles
• Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12  Journal Articles
• Inhalation injury in severely burned children does not augment the systemic inflammatory response  Journal Articles
• Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression  Journal Articles
• Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice  Journal Articles
• Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw  Journal Articles
• Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors  Journal Articles
• Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice  Journal Articles
• Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes  Journal Articles
• Life-long systemic protection in mice vaccinated with and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes  Journal Articles
• Local interleukin‐12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis  Journal Articles
• Macrophages are a significant source of type 1 cytokines during mycobacterial infection  Journal Articles
• Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs  Journal Articles
• Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma  Journal Articles
• Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination  Journal Articles
• Propranolol as a modulator of M2b monocytes in severely burned patients  Journal Articles
• Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity  Journal Articles
• Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway  Journal Articles
• Replication-Defective Adenovirus Infection ReducesHelicobacter felisColonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner  Journal Articles
• Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction  Journal Articles
• Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile  Journal Articles
• Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells  Journal Articles
• Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism  Journal Articles
• Th1 Cytokines and the Prothrombinase fgl2 in Stress‐triggered and Inflammatory Abortion  Journal Articles
• The breast tumor microenvironment alters the phenotype and function of natural killer cells  Journal Articles
• Transient Gene Transfer of IL-12 Regulates Chemokine Expression and Disease Severity in Experimental Arthritis  Journal Articles
• Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice  Journal Articles
• Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: Preclinical studies in myeloma  Journal Articles
• Use of cytokines in infection  Journal Articles