Interleukin-12
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2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis Academic Article
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A pilot, open-label, 8-week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression Academic Article
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A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model Academic Article
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A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice. Academic Article
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ANTI-INTERLEUKIN-12 THERAPY PROTECTS MICE IN LETHAL ENDOTOXEMIA BUT IMPAIRS BACTERIAL CLEARANCE IN MURINE ESCHERICHIA COLI PERITONEAL SEPSIS Academic Article
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Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models Academic Article
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Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors Academic Article
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Autologous lymphocyte responses to adenovirus-B7-1-transduced human cancer cells Academic Article
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Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required. Academic Article
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Briakinumab Academic Article
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Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance Academic Article
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Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity Academic Article
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Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells Academic Article
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Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy Academic Article
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Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12 Academic Article
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Culture of myeloid dendritic cells from bone marrow precursors Academic Article
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Dendritic Cell-Derived IL-12 Is Not Required for the Generation of Cytotoxic, IFN-γ-Secreting, CD8+CTL In Vivo Academic Article
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Dendritic cells expressing TGFβ/IL-10, and CHO cells with OX-2, increase graft survival Academic Article
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Different profiles of T-cell IFN-γ and IL-12 in allergen-induced early and dual responders with asthma Academic Article
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Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity Academic Article
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Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12 Academic Article
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Effect of alginate on innate immune activation of macrophages Academic Article
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Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response Academic Article
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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2) Academic Article
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Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration Academic Article
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Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene Academic Article
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FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice Academic Article
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Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines. Academic Article
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Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy Academic Article
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Human milk composition differs in healthy mothers and mothers with celiac disease Academic Article
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IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. Academic Article
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IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice Academic Article
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IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure Academic Article
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IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes Academic Article
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IL-15 has innate anti-tumor activity independent of NK and CD8 T cells Academic Article
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IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation Academic Article
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IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion Academic Article
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Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis Academic Article
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Increased production of IFN-γ by natural killer cells triggered with bone marrow-derived dendritic cells cultured in the presence of retinoic acid Academic Article
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Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12 Academic Article
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Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression Academic Article
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Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice Academic Article
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Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw Academic Article
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Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors Academic Article
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Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice. Academic Article
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Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes Academic Article
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Life-long systemic protection in mice vaccinated with and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes Academic Article
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Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis Academic Article
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Macrophages are a significant source of type 1 cytokines during mycobacterial infection Academic Article
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Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs Academic Article
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Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma Academic Article
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Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination Academic Article
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Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity Academic Article
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Reduction of Serum Melatonin Levels
in HIV-1-Infected Individuals’ Parallel Disease Progression:
Correlation with Serum Interleukin-12 Levels Academic Article
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Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway Academic Article
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Replication-Defective Adenovirus Infection Reduces
Helicobacter felis
Colonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner Academic Article
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Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-alpha and nitric oxide from macrophages via IFN-gamma induction. Academic Article
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Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile Academic Article
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Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells Academic Article
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Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism Academic Article
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Th1 Cytokines and the Prothrombinase fgl2 in Stress-triggered and Inflammatory Abortion Academic Article
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The breast tumor microenvironment alters the phenotype and function of natural killer cells Academic Article
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Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis. Academic Article
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Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice Academic Article
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Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: Preclinical studies in myeloma Academic Article
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Use of cytokines in infection Academic Article