Interleukin-12 Concept

subject area of

• A pilot, open-label, 8-week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression  Academic Article
• A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model  Academic Article
• A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice.  Academic Article
• ANTI-INTERLEUKIN-12 THERAPY PROTECTS MICE IN LETHAL ENDOTOXEMIA BUT IMPAIRS BACTERIAL CLEARANCE IN MURINE ESCHERICHIA COLI PERITONEAL SEPSIS  Academic Article
• Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models  Academic Article
• Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors  Academic Article
• Autologous lymphocyte responses to adenovirus-B7-1-transduced human cancer cells  Academic Article
• Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required.  Academic Article
• Briakinumab  Academic Article
• Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance  Academic Article
• Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity  Academic Article
• Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells  Academic Article
• Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy  Academic Article
• Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine: In Vitro and In Vivo Production of Biologically Active Interleukin-12  Academic Article
• Culture of myeloid dendritic cells from bone marrow precursors  Academic Article
• Dendritic Cell-Derived IL-12 Is Not Required for the Generation of Cytotoxic, IFN-γ-Secreting, CD8+ CTL In Vivo  Academic Article
• Dendritic cells expressing TGFβ/IL-10, and CHO cells with OX-2, increase graft survival  Academic Article
• Different profiles of T-cell IFN-γ and IL-12 in allergen-induced early and dual responders with asthma  Academic Article
• Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity  Academic Article
• Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12  Academic Article
• Effect of Thymoquinone on Mouse Dendritic Cells  Academic Article
• Effect of alginate on innate immune activation of macrophages  Academic Article
• Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)  Academic Article
• Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration  Academic Article
• Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene  Academic Article
• FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice  Academic Article
• Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines.  Academic Article
• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy  Academic Article
• IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.  Academic Article
• IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice  Academic Article
• IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure  Academic Article
• IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes  Academic Article
• IL-15 has innate anti-tumor activity independent of NK and CD8 T cells  Academic Article
• IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation  Academic Article
• IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion  Academic Article
• Increased production of IFN-γ by natural killer cells triggered with bone marrow-derived dendritic cells cultured in the presence of retinoic acid  Academic Article
• Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12  Academic Article
• Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression  Academic Article
• Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw  Academic Article
• Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors  Academic Article
• Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.  Academic Article
• Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes  Academic Article
• Life-long systemic protection in mice vaccinated with and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes  Academic Article
• Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis  Academic Article
• Macrophages are a significant source of type 1 cytokines during mycobacterial infection  Academic Article
• Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs  Academic Article
• Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma  Academic Article
• Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination  Academic Article
• Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity  Academic Article
• Reduction of serum melatonin levels in HIV-1-infected individuals' parallel disease progression: correlation with serum interleukin-12 levels.  Academic Article
• Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway  Academic Article
• Replication-defective adenovirus infection reduces Helicobacter felis colonization in the mouse in a gamma interferon- and interleukin-12-dependent manner.  Academic Article
• Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-alpha and nitric oxide from macrophages via IFN-gamma induction.  Academic Article
• Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile  Academic Article
• Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells  Academic Article
• Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism  Academic Article
• Th1 Cytokines and the Prothrombinase fgl2 in Stress-triggered and Inflammatory Abortion  Academic Article
• The breast tumor microenvironment alters the phenotype and function of natural killer cells  Academic Article
• Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis.  Academic Article
• Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice  Academic Article
• Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: Preclinical studies in myeloma  Academic Article
• Use of cytokines in infection  Academic Article