Interleukin-12
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2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis Journal Articles
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A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice AgainstLeishmania majorInfection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice Journal Articles
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A pilot, open‐label, 8‐week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression Journal Articles
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A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model Journal Articles
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ANTI-INTERLEUKIN-12 THERAPY PROTECTS MICE IN LETHAL ENDOTOXEMIA BUT IMPAIRS BACTERIAL CLEARANCE IN MURINE ESCHERICHIA COLI PERITONEAL SEPSIS Journal Articles
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Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models Journal Articles
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Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors Journal Articles
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Autologous lymphocyte responses to adenovirus-B7-1-transduced human cancer cells Journal Articles
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Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required for host defense against viral infections Journal Articles
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Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required. Journal Articles
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Briakinumab Journal Articles
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Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance Journal Articles
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Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity Journal Articles
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Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells Journal Articles
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Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy Journal Articles
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Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine:In VitroandIn VivoProduction of Biologically Active Interleukin-12 Journal Articles
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Culture of myeloid dendritic cells from bone marrow precursors Journal Articles
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Dendritic Cell-Derived IL-12 Is Not Required for the Generation of Cytotoxic, IFN-γ-Secreting, CD8+ CTL In Vivo Journal Articles
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Dendritic cells expressing TGFβ/IL-10, and CHO cells with OX-2, increase graft survival Journal Articles
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Different profiles of T-cell IFN-γ and IL-12 in allergen-induced early and dual responders with asthma Journal Articles
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Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity Journal Articles
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Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12 Journal Articles
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Effect of alginate on innate immune activation of macrophages Journal Articles
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Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response Journal Articles
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Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn’s Disease: Systematic Review and Meta-Analysis Journal Articles
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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2) Journal Articles
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Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration Journal Articles
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Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene Journal Articles
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FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice Journal Articles
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Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines. Journal Articles
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HIV-1 alters T helper cytokines, interleukin-12 and interleukin-18 responses to the protozoan parasite Leishmania donovani Journal Articles
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Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy Journal Articles
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Human milk composition differs in healthy mothers and mothers with celiac disease Journal Articles
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IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. Journal Articles
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IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice Journal Articles
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IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes Journal Articles
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IL-15 has innate anti-tumor activity independent of NK and CD8 T cells Journal Articles
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IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation Journal Articles
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IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion Journal Articles
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IL‐12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure Journal Articles
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Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis Journal Articles
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Impaired ability of burn patient neutrophils to stimulate β‐defensin production by keratinocytes Journal Articles
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Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12 Journal Articles
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Inhalation injury in severely burned children does not augment the systemic inflammatory response Journal Articles
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Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression Journal Articles
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Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice Journal Articles
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Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw Journal Articles
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Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors Journal Articles
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Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice Journal Articles
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Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes Journal Articles
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Life-long systemic protection in mice vaccinated with and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes Journal Articles
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Local interleukin‐12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis Journal Articles
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Macrophages are a significant source of type 1 cytokines during mycobacterial infection Journal Articles
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Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs Journal Articles
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Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma Journal Articles
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Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination Journal Articles
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Propranolol as a modulator of M2b monocytes in severely burned patients Journal Articles
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Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity Journal Articles
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Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway Journal Articles
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Replication-Defective Adenovirus Infection ReducesHelicobacter felisColonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner Journal Articles
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Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction Journal Articles
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Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile Journal Articles
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Suppression of Immunological Response Against a Transgene Product Delivered from Microencapsulated Cells Journal Articles
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Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-γ-Dependent Mechanism Journal Articles
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Th1 Cytokines and the Prothrombinase fgl2 in Stress‐triggered and Inflammatory Abortion Journal Articles
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The breast tumor microenvironment alters the phenotype and function of natural killer cells Journal Articles
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Transient Gene Transfer of IL-12 Regulates Chemokine Expression and Disease Severity in Experimental Arthritis Journal Articles
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Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice Journal Articles
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Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: Preclinical studies in myeloma Journal Articles
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Use of cytokines in infection Journal Articles