Journal article
Local interleukin‐12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis
Abstract
OBJECTIVE: To determine whether local overexpression of interleukin-12 (IL-12), a pleiotropic cytokine that promotes the development of naive T cells into Th1 cells, could aggravate murine streptococcal cell wall (SCW)-induced arthritis, a model of acute arthritis.
METHODS: C57BL/6 mice were injected intraarticularly with saline or with 10(7) plaque-forming units of control vector (Ad5del70-3) or IL-12 vector (AdmIL-12.1) into the right knee …
Authors
Joosten LAB; Heuvelmans‐Jacobs M; Lubberts E; Van De Loo FAJ; Bakker AC; Helsen MMA; Richards CD; Van Den Berg WB
Journal
Arthritis & Rheumatism, Vol. 46, No. 5, pp. 1379–1389
Publisher
Wiley
Publication Date
5 2002
DOI
10.1002/art.10233
ISSN
0004-3591