Journal article
Large Nontransplanted Hepatocellular Carcinoma in Woodchucks: Treatment With Adenovirus-Mediated Delivery of Interleukin 12/B7.1 Genes
Abstract
BACKGROUND: Cytokine-based gene therapy strategies efficiently stimulate immune responses against many established transplanted tumors, leading to rejection of the tumor. In this study, we investigated the therapeutic potential of cancer immunotherapy in a clinically more relevant model, woodchucks with primary hepatocellular carcinomas induced by woodchuck hepatitis virus.
METHODS: Large (2-5 cm), established intrahepatic tumors were given an …
Authors
Pützer BM; Stiewe T; Rödicker F; Schildgen O; Rühm S; Dirsch O; Fiedler M; Damen U; Tennant B; Scherer C
Journal
Journal of the National Cancer Institute, Vol. 93, No. 6, pp. 472–479
Publisher
Oxford University Press (OUP)
Publication Date
March 21, 2001
DOI
10.1093/jnci/93.6.472
ISSN
0027-8874