Journal article
Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw
Abstract
We studied the effects of local IL-10 application, introduced by a recombinant human type 5 adenovirus vector, in the mouse knee joint during the early phase of CIA. One intra-articular injection with the IL-10-expressing virus (Ad5E1mIL-10) caused substantial over-expression of IL-10 in the mouse knee joint, using virus dosages which did not induce distracting inflammation. High expression of IL-10 was noted for a few days, being maximal at …
Authors
Lubberts E; Joosten LAB; Van Den Bersselaar L; Helsen MMA; Bakker AC; Xing Z; Richards CD; Van Den Berg WB
Journal
Clinical & Experimental Immunology, Vol. 120, No. 2, pp. 375–383
Publisher
Oxford University Press (OUP)
Publication Date
December 24, 2001
DOI
10.1046/j.1365-2249.2000.01217.x
ISSN
0009-9104