selected scholarly activity
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conferences
- Phase I study of oncolytic virus (OV) MG1 maraba/MAGE-A3 (MG1MA3), with and without transgenic MAGE-A3 adenovirus vaccine (AdMA3) in incurable advanced/metastatic MAGE-A3-expressing solid tumours: CCTG IND.214.. Journal of Clinical Oncology. e14637-e14637. 2017
- DEVELOPMENT AND APPLICATION OF A NOVEL MODEL OF HUMAN LUNG-TO-BRAIN METASTASIS TO IDENTIFY GENETIC REGULATORS OF BRAIN METASTASIS INITIATING CELLS. Neuro-Oncology. 211-212. 2016
- OCOG-ALMERA: A phase II trial investigating the ability of metformin to chemo-radio-sensitize and prevent recurrence in locally advanced (LA) non-small cell lung cancer (NSCLC)∗. Journal of Thoracic Oncology. S50-S51. 2016
- Low Prevalence of High Grade Lesions Detected With Autofluorescence Bronchoscopy in the Setting of Lung Cancer Screening in the Pan-Canadian Lung Cancer Screening Study. Chest. 547A-547A. 2015
- A targeted intervention to improve awareness to molecular testing in NSCLC.. Journal of Clinical Oncology. 6547-6547. 2014
- The Cost-Effectiveness of 2nd Line Crizotinib in EML4-Alk Rearranged Advanced NSCLC in Ontario. Value in Health. A90-A90. 2014
- HPV Genotyping in Vulvar Squamous Cell Carcinoma: Comparison of a Luminex-Based Assay vs Linear Array. Modern Pathology. 305A-305A. 2014
- HPV Genotyping in Vulvar Squamous Cell Carcinoma: Comparison of a Luminex-Based Assay vs Linear Array. Laboratory Investigation. 305A-305A. 2014
- Cost-Effectiveness of EML4-ALK Fusion Testing and First-Line Crizotinib Treatment for Patients with Advanced ALK Positive Non-Small Cell Lung Cancer in a Publicly Funded System (Ontario, Canada). Value in Health. A410-A410. 2013
- Canadian ALK (CALK): A pan-Canadian multicenter study to optimize and standardize ALK immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for ALK gene rearrangements. Journal of Clinical Oncology. 2013
- Cost-Effectiveness Of Eml4-Alk Fusion Testing In Combination With Crizotinib Treatment For Patients With Advanced Non-Small Cell Lung Cancer Living In Ontario. Value in Health. A142-A142. 2013
- THE ANTI-DIABETIC DRUG METFORMIN SENSITIZES HUMAN NON-SMALL CELL LUNG CANCER (NSCLC) XENOGRAFTS TO IONIZING RADIATION.. Journal of Thoracic Oncology. S571-S572. 2011
- Abstract 2491: Metformin sensitizes human lung cancer xenografts to ionizing radiation: Response of the AMPK pathway. Cancer Research. 2491-2491. 2011
- Immunohistochemistry for phosphorylated EGF receptor predicts survival and phosphorylated ERK predicts tumor response to chemo-radiotherapy in unresectable, locally advanced non-small cell lung cancer patients. Laboratory Investigation. 339A-339A. 2008
- Immunohistochemistry for phosphorylated EGF receptor predicts survival and phosphorylated ERK predicts tumor response to chemoradiotherapy in unresectable, locally advanced non-small cell lung cancer patients. Modern Pathology. 339A-339A. 2008
- Plasma membrane and cytoplasmic activated EGF receptor predicts survival and cytoplasmic activated Erk predicts tumour response in locally advanced NSCLC patients treated with chemo-radiotherapy. Radiotherapy and Oncology. S57-S57. 2007
- Detection of PTEN deletion in prostate cancer but not prostatic intra-epithelial neoplasia by fluorescence in situ hybridization using tissue microarrays. Chromosome Research. 96-96. 2005
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journal articles
- Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer. Laboratory Investigation. 104:102076-102076. 2024
- Canadian Multicentric Pan-TRK (CANTRK) Immunohistochemistry Harmonization Study. Modern Pathology. 37:100384-100384. 2024
- Neuroanatomical location of lung cancer brain metastases in 234 patients with a focus on cancer subtyping and biomarkers.. PLoS ONE. 19:e0314205. 2024
- Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance. International Journal of Molecular Sciences. 24:16022-16022. 2023
- Assessing Oral Epithelial Dysplasia Risk for Transformation to Cancer: Comparison Between Histologic Grading Systems Versus S100A7 Immunohistochemical Signature-based Grading. Applied Immunohistochemistry and Molecular Morphology. 31:399-405. 2023
- The physician factor and anatomical site in 8846 consecutive mediastinal lymph node aspirations in a cross-sectional study. Scientific Reports. 13:1784. 2023
- Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history. PLoS ONE. 18:e0294154-e0294154. 2023
- Multiple lung nodules, eosinophilia and severe asthma. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:319-322. 2022
- A 68-Year-Old Woman With Refractory Cough and Insidious Tracheal Thickening. Chest. 161:e287-e291. 2022
- Pathologist workload, work distribution and significant absences or departures at a regional hospital laboratory. PLoS ONE. 17:e0265905-e0265905. 2022
- Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer. Lung Cancer. 160:127-135. 2021
- FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role. American Journal of Respiratory Cell and Molecular Biology. 64:235-246. 2021
- Evolution of anatomic pathology workload from 2011 to 2019 assessed in a regional hospital laboratory via 574,093 pathology reports. PLoS ONE. 16:e0253876-e0253876. 2021
- Canadian Multicenter Project on Standardization of Programmed Death-Ligand 1 Immunohistochemistry 22C3 Laboratory-Developed Tests for Pembrolizumab Therapy in NSCLC. Journal of Thoracic Oncology. 15:1328-1337. 2020
- TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. Arteriosclerosis, Thrombosis and Vascular Biology. 40:1664-1679. 2020
- Immunohistochemistry Use by Diagnostic Category and Pathologist in 4477 Prostate Core Biopsy Sets Assessed at Two Hospitals. Applied Immunohistochemistry and Molecular Morphology. 28:259-266. 2020
- Crizotinib Inhibition of ROS1-Positive Tumours in Advanced Non-Small-Cell Lung Cancer: A Canadian Perspective. Current Oncology. 26:551-557. 2019
- Reactive Nodular Fibrous Pseudotumor Mimicking Metastatic Gastrointestinal Stromal Tumor to Perigastric Lymph Node: A Case Report and Review of the Literature. International Journal of Surgical Pathology. 26:664-670. 2018
- Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development. Translational Oncology. 11:1012-1022. 2018
- Translation of Knowledge to Practice—Improving Awareness in NSCLC Molecular Testing. Journal of Thoracic Oncology. 13:1004-1011. 2018
- Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues. Frontiers in Oncology. 8:100. 2018
- RNAi screen identifies essential regulators of human brain metastasis-initiating cells. Acta Neuropathologica. 134:923-940. 2017
- Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study. The Lancet Oncology. 18:1523-1531. 2017
- A Novel Neoadjuvant Therapy for Operable Locally Invasive Non–Small-Cell Lung Cancer. Phase I Study of Neoadjuvant Stereotactic Body Radiotherapy. LINNEARRE I (NCT02433574). Clinical Lung Cancer. 18:436-440.e1. 2017
- Improving Molecular Testing and Personalized Medicine in Non-Small-Cell Lung Cancer in Ontario. Current Oncology. 24:103-110. 2017
- Upregulation of FAM84B during prostate cancer progression. Oncotarget. 8:19218-19235. 2017
- Amplification of MUC1 in prostate cancer metastasis and CRPC development. Oncotarget. 7:83115-83133. 2016
- Low Prevalence of High-Grade Lesions Detected With Autofluorescence Bronchoscopy in the Setting of Lung Cancer Screening in the Pan-Canadian Lung Cancer Screening Study. Chest. 150:1015-1022. 2016
- Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth. Journal of the American Heart Association. 5:e003945. 2016
- Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer. Cancer Research. 76:1603-1614. 2016
- Local molecular analysis of indeterminate thyroid nodules. Journal of Otolaryngology - Head and Neck Surgery. 44:52. 2015
- Developing ALK Immunohistochemistry and In Situ Hybridization Proficiency Testing for Non–Small Cell Lung Cancer in Canada. Applied Immunohistochemistry and Molecular Morphology. 23:677-681. 2015
- Diagnosing Lung Cancer in the 21st Century: Are We Ready to Meet the Challenge of Individualized Care?. Current Oncology. 22:272-278. 2015
- Novel function of Oncostatin M as a potent tumour‐promoting agent in lung. International Journal of Cancer. 136:831-843. 2015
- IQGAP2 Displays Tumor Suppression Functions. Journal of Analytical Oncology. 4:86-93. 2015
- Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada. Journal of Thoracic Oncology. 9:1449-1458. 2014
- Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma. Oncotarget. 5:7406-7419. 2014
- Canadian Anaplastic Lymphoma Kinase Study: A Model for Multicenter Standardization and Optimization of ALK Testing in Lung Cancer. Journal of Thoracic Oncology. 9:1255-1263. 2014
- Changes in PKM2 Associate with Prostate Cancer Progression. Cancer Investigation. 32:330-338. 2014
- Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis. British Journal of Cancer. 110:2593-2603. 2014
- Cost Effectiveness of EML4-ALK Fusion Testing and First-Line Crizotinib Treatment for Patients With Advanced ALK-Positive Non–Small-Cell Lung Cancer. Journal of Clinical Oncology. 32:1012-1019. 2014
- Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin. European Journal of Cancer. 49:3537-3546. 2013
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. British Journal of Cancer. 108:2021-2032. 2013
- Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiation Oncology. 7:71. 2012
- IQGAP2, A candidate tumour suppressor of prostate tumorigenesis. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1822:875-884. 2012
- Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1813:683-694. 2011
- α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells. Nature Communications. 2:307. 2011
- Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells. International Journal of Radiation Oncology Biology Physics. 78:221-229. 2010
- PTEN inhibits BMI1 function independently of its phosphatase activity. Molecular Cancer. 8:98. 2009
- Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1782:642-648. 2008
- Phase II Study of Erlotinib in Recurrent or Metastatic Endometrial Cancer: NCIC IND-148. Journal of Clinical Oncology. 26:4319-4325. 2008
- Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. Journal of Clinical Oncology. 26:4268-4275. 2008
- Association of Phosphorylated Epidermal Growth Factor Receptor with Survival in Patients with Locally Advanced Non-small Cell Lung Cancer Treated with Radiotherapy. Journal of Thoracic Oncology. 3:716-722. 2008
- Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation. Cancer Cell International. 7:14. 2007
- A common presentation with a rare cause. European Respiratory Journal. 30:594-597. 2007
- Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy. Prostate. 67:162-171. 2007
- Fever of Unknown Origin in a Migrant Farm Worker from Mexico: History, Her Story and His Story. Canadian Journal of Infectious Diseases and Medical Microbiology. 18:368-369. 2007
- ATM activation is accompanied with earlier stages of prostate tumorigenesis. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1763:1090-1097. 2006
- Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer genetics. 169:128-137. 2006
- Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes. Clinical Cancer Research. 12:4043-4054. 2006
- Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. British Journal of Cancer. 94:1452-1459. 2006
- An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Laboratory Investigation. 85:1392-1404. 2005
- Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome. New England Journal of Medicine. 353:133-144. 2005
- Brain region-specific and time-dependent decreases of G?i2 in amygdala-kindled rats. Synapse. 22:226-231. 1996