Pyrimidines Concept

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• 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty  Journal Articles
• 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty  Journal Articles
• 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis  Journal Articles
• A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial  Journal Articles
• A Clinician's Guide to the Treatment of Endometriosis with Elagolix  Journal Articles
• A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction  Journal Articles
• A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients  Journal Articles
• An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.  Journal Articles
• Assessment of Alectinib vs Ceritinib in ALK-Positive Non–Small Cell Lung Cancer in Phase 2 Trials and in Real-world Data  Journal Articles
• Association of Bicuspid Aortic Valve Morphology and Aortic Root Dimensions: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) Study  Journal Articles
• Azapirones for generalized anxiety disorder  Journal Articles
• Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation  Journal Articles
• Bruton’s tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK  Journal Articles
• CD206⁺macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis  Journal Articles
• Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma  Journal Articles
• Cardiovascular Events After Exposure to Nilotinib in Chronic Myeloid Leukemia: Long-term Follow-up  Journal Articles
• Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis  Journal Articles
• Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimen  Journal Articles
• Circulating Levels of Matrix Gla Protein and Progression of Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial  Journal Articles
• Clinical Usefulness of Tissue Doppler Imaging in Patients with Mild to Moderate Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin Study  Journal Articles
• Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)  Journal Articles
• Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors  Journal Articles
• Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium  Journal Articles
• Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib  Journal Articles
• Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia  Journal Articles
• Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors  Journal Articles
• Early high-dose rosuvastatin prevented contrast-induced acute kidney injury in non–ST-elevation ACS  Journal Articles
• Early tumor shrinkage is independently associated with improved overall survival among patients with metastatic renal cell carcinoma: a validation study using the COMPARZ cohort  Journal Articles
• Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia  Journal Articles
• Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis  Journal Articles
• Effect of RA233 on Platelet Function In Vitro  Journal Articles
• Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis  Journal Articles
• Effect of tofacitinib withdrawal and re‐treatment on patient‐reported outcomes: results from a Phase 3 study in patients with moderate to severe chronic plaque psoriasis  Journal Articles
• Effectin vitroon platelet function of two compounds developed from the pyrimido-pyrimidines  Journal Articles
• Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction  Journal Articles
• Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough  Journal Articles
• Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial  Journal Articles
• Efficacy and safety of tofacitinib dose de‐escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open  Journal Articles
• Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer  Journal Articles
• Energy-stress-mediated AMPK activation inhibits ferroptosis  Journal Articles
• Esophageal gastrointestinal stromal tumor: report of 7 patients  Journal Articles
• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Journal Articles
• Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma  Journal Articles
• Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo‐controlled trials  Journal Articles
• Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open‐label study  Journal Articles
• Gefapixant for Chronic Cough—Reply  Journal Articles
• High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells  Journal Articles
• Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties  Journal Articles
• Identification and Biochemical Studies on Novel Non-Nucleoside Inhibitors of the Enzyme Adenosine Kinase  Journal Articles
• Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET  Journal Articles
• Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study  Journal Articles
• Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin  Journal Articles
• Imatinib mesylate in children and adolescents with cancer  Journal Articles
• Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development  Journal Articles
• Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups  Journal Articles
• Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors  Journal Articles
• Influence of Cleavage Site on Global Folding of an RNA‐Cleaving DNAzyme  Journal Articles
• Insulin Resistance and LVH Progression in Patients With Calcific Aortic Stenosis  Journal Articles
• Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors  Journal Articles
• International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Letter: corticosteroid use alongside tofacitinib in OCTAVE Open. Authors' reply  Journal Articles
• Lipid lowering for primary prevention  Journal Articles
• Long-Term Outcomes of Elagolix in Women With Endometriosis  Journal Articles
• Long‐term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program  Journal Articles
• Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension  Journal Articles
• Mapping the Sinorhizobium meliloti 1021 solute-binding protein-dependent transportome  Journal Articles
• Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants  Journal Articles
• Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma  Journal Articles
• Meteorites and the RNA World: A Thermodynamic Model of Nucleobase Synthesis within Planetesimals  Journal Articles
• Milvexian for the Prevention of Venous Thromboembolism  Journal Articles
• Modulation of postdecapitation convulsions in rats by α-adrenergic and 5-hydroxytryptamine1A agents  Journal Articles
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Journal Articles
• Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure  Journal Articles
• P2Y₂ Receptor Up-Regulation Induced by Guanosine or UTP in Rat Brain Cultured Astrocytes  Journal Articles
• Patterns of Ruxolitinib Therapy Failure and Its Management in Myelofibrosis: Perspectives of the Canadian Myeloproliferative Neoplasm Group  Journal Articles
• Physician- and Patient-reported Effectiveness Are Similar for Tofacitinib and TNFi in Rheumatoid Arthritis: Data From a Rheumatoid Arthritis Registry  Journal Articles
• Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease  Journal Articles
• Prevalence of endoscopic improvement and remission according to patient‐reported outcomes in ulcerative colitis  Journal Articles
• Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor α and γ ligands  Journal Articles
• Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells  Journal Articles
• Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis  Journal Articles
• Resolution of rectal bleeding by day 7 in acute severe ulcerative colitis is prognostic for post-discharge corticosteroid free clinical remission and endoscopic improvement  Journal Articles
• Riociguat for the treatment of pulmonary hypertension  Journal Articles
• Riociguat: A Novel Therapeutic Option for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension  Journal Articles
• Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4  Journal Articles
• Risk of hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive patients with myeloproliferative neoplasms treated with ruxolitinib  Journal Articles
• SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension  Journal Articles
• Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available  Journal Articles
• Sensitivity of multiple life stages of 2 freshwater mussel species (Unionidae) to various pesticides detected in Ontario (Canada) surface waters  Journal Articles
• Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats  Journal Articles
• Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance  Journal Articles
• Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results  Journal Articles
• Targeted therapy for metastatic renal cell carcinoma  Journal Articles
• Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer  Journal Articles
• The Peroxisome Proliferator Response Element of the Gene Encoding the Peroxisomal β-Oxidation Enzyme Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase Is a Target for Constitutive Androstane Receptor β/9-cis-Retinoic Acid Receptor-mediated Transactivation  Journal Articles
• The current role of Tofacitinib in acute severe ulcerative colitis in adult patients: A systematic review  Journal Articles
• The endothelin 1a receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein–carotid artery interposition grafts  Journal Articles
• The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer  Journal Articles
• The impact of ruxolitinib on thrombosis in patients with polycythemia vera and myelofibrosis  Journal Articles
• The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis  Journal Articles
• The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase  Journal Articles
• Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia  Journal Articles
• Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline  Journal Articles
• Thrombopoietin Receptor Agonists and Other Second-Line Therapies for Immune Thrombocytopenia: A Narrative Review With a Focus on Drug Access in Canada  Journal Articles
• Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study  Journal Articles
• Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4.  Journal Articles
• Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis  Journal Articles
• Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist  Journal Articles
• Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases  Journal Articles
• Use of the Dual Potential to Rationalize the Occurrence of Some DNA Lesions (Pyrimidic Dimers)  Journal Articles
• Vericiguat reduced a composite of CV death or HF hospitalization in patients with HF and reduced LVEF  Journal Articles
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors  Conferences
• hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process  Journal Articles
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Journal Articles