Pyrimidines
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Overview
subject area of
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2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty Academic Article
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2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty Academic Article
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2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis Academic Article
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A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial Academic Article
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A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours Academic Article
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A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction Academic Article
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A Phase II Study of Pazopanib in Patients with Recurrent or Metastatic Invasive Breast Carcinoma: A Trial of the Princess Margaret Hospital Phase II Consortium Academic Article
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A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients Academic Article
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An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice. Academic Article
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Assessment of Alectinib vs Ceritinib in ALK-Positive Non–Small Cell Lung Cancer in Phase 2 Trials and in Real-world Data Academic Article
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Association of Bicuspid Aortic Valve Morphology and Aortic Root Dimensions: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) Study Academic Article
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Azapirones for generalized anxiety disorder Academic Article
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Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation Academic Article
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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma Academic Article
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Cardiovascular Events After Exposure to Nilotinib in Chronic Myeloid Leukemia: Long-term Follow-up Academic Article
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Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis Academic Article
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Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimen Academic Article
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Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials Academic Article
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Circulating Levels of Matrix Gla Protein and Progression of Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial Academic Article
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Clinical Usefulness of Tissue Doppler Imaging in Patients with Mild to Moderate Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin Study Academic Article
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Comparison of Rosuvastatin Versus Atorvastatin in South-Asian Patients at Risk of Coronary Heart Disease (from the IRIS Trial) Academic Article
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Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors Academic Article
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Cystathionine β-Lyase Is Important for Virulence of
Salmonella enterica
Serovar Typhimurium Academic Article
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Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib Academic Article
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Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia Academic Article
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Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors Academic Article
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Early high-dose rosuvastatin prevented contrast-induced acute kidney injury in non–ST-elevation ACS Academic Article
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Early tumor shrinkage is independently associated with improved overall survival among patients with metastatic renal cell carcinoma: a validation study using the COMPARZ cohort Academic Article
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Effect in vitro on platelet function of two compounds developed from the pyrimido-pyrimidines Academic Article
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Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia Academic Article
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Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis Academic Article
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Effect of RA233 on Platelet Function In Vitro Academic Article
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Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis Academic Article
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Effect of tofacitinib withdrawal and re-treatment on patient-reported outcomes: results from a Phase 3 study in patients with moderate to severe chronic plaque psoriasis Academic Article
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Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction Academic Article
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Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial Academic Article
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Efficacy and safety of tofacitinib dose de-escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open Academic Article
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Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer Academic Article
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Energy-stress-mediated AMPK activation inhibits ferroptosis Academic Article
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Esophageal gastrointestinal stromal tumor: report of 7 patients Academic Article
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Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Academic Article
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Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma Academic Article
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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials Academic Article
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Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open‐label study Academic Article
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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Academic Article
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Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study Academic Article
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Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties Academic Article
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Identification and Biochemical Studies on Novel Non-Nucleoside Inhibitors of the Enzyme Adenosine Kinase Academic Article
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Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET Academic Article
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Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study Academic Article
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Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin Academic Article
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Imatinib mesylate in children and adolescents with cancer Academic Article
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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development Academic Article
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Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups Academic Article
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Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis Academic Article
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Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors Academic Article
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Influence of Cleavage Site on Global Folding of an RNA-Cleaving DNAzyme Academic Article
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Insulin Resistance and LVH Progression in Patients With Calcific Aortic Stenosis Academic Article
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Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors Academic Article
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International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction Academic Article
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Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells Academic Article
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Letter: corticosteroid use alongside tofacitinib in OCTAVE Open. Authors' reply Academic Article
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Lipid lowering for primary prevention Academic Article
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Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia Academic Article
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Long‐term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program Academic Article
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Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension Academic Article
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Mapping the
Sinorhizobium meliloti
1021 solute-binding protein-dependent transportome Academic Article
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Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants Academic Article
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Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma Academic Article
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Meteorites and the RNA World: A Thermodynamic Model of Nucleobase Synthesis within Planetesimals Academic Article
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Milvexian for the Prevention of Venous Thromboembolism Academic Article
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Modulation of postdecapitation convulsions in rats by α-adrenergic and 5-hydroxytryptamine1A agents Academic Article
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Multiple Fungal Brain Abscesses in a Child with Acute Lymphoblastic Leukemia Academic Article
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Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine Academic Article
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Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure Academic Article
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P2Y2 Receptor Up-Regulation Induced by Guanosine or UTP in Rat Brain Cultured Astrocytes Academic Article
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Patterns of Ruxolitinib Therapy Failure and Its Management in Myelofibrosis: Perspectives of the Canadian Myeloproliferative Neoplasm Group Academic Article
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Physician- and Patient-reported Effectiveness Are Similar for Tofacitinib and TNFi in Rheumatoid Arthritis: Data From a Rheumatoid Arthritis Registry Academic Article
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Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease Academic Article
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Prevalence of endoscopic improvement and remission according to patient-reported outcomes in ulcerative colitis Academic Article
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Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells Academic Article
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Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis Academic Article
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Riociguat for the treatment of pulmonary hypertension Academic Article
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Riociguat: A Novel Therapeutic Option for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension Academic Article
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Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4 Academic Article
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Risk of hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive patients with myeloproliferative neoplasms treated with ruxolitinib Academic Article
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SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension Academic Article
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Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma Academic Article
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Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available Academic Article
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Sensitivity of multiple life stages of 2 freshwater mussel species (Unionidae) to various pesticides detected in Ontario (Canada) surface waters Academic Article
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Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats Academic Article
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Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance Academic Article
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Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results Academic Article
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Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial Academic Article
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TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state Academic Article
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Targeted therapy for metastatic renal cell carcinoma Academic Article
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Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer Academic Article
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The Peroxisome Proliferator Response Element of the Gene Encoding the Peroxisomal β-Oxidation Enzyme Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase Is a Target for Constitutive Androstane Receptor β/9-cis-Retinoic Acid Receptor-mediated Transactivation Academic Article
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The endothelin 1a receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein–carotid artery interposition grafts Academic Article
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The ground state of embryonic stem cell self-renewal Academic Article
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The impact of ruxolitinib on thrombosis in patients with polycythemia vera and myelofibrosis Academic Article
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The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis Academic Article
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The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase Academic Article
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Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia Academic Article
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Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline Academic Article
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Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase
III
Study Academic Article
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Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4. Academic Article
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Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis Academic Article
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Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist Academic Article
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Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma Academic Article
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Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases Academic Article
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Use of the Dual Potential to Rationalize the Occurrence of Some DNA Lesions (Pyrimidic Dimers) Academic Article
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Vericiguat reduced a composite of CV death or HF hospitalization in patients with HF and reduced LVEF Academic Article
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XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors Conference Paper
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hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process Academic Article
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β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer Academic Article