Pyrimidines Concept

subject area of

• 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty  Academic Article
• 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty  Academic Article
• 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis  Academic Article
• A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial  Academic Article
• A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours  Academic Article
• A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction  Academic Article
• A Phase II Study of Pazopanib in Patients with Recurrent or Metastatic Invasive Breast Carcinoma: A Trial of the Princess Margaret Hospital Phase II Consortium  Academic Article
• A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients  Academic Article
• An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.  Academic Article
• Assessment of Alectinib vs Ceritinib in ALK-Positive Non–Small Cell Lung Cancer in Phase 2 Trials and in Real-world Data  Academic Article
• Association of Bicuspid Aortic Valve Morphology and Aortic Root Dimensions: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) Study  Academic Article
• Azapirones for generalized anxiety disorder  Academic Article
• Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation  Academic Article
• Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma  Academic Article
• Cardiovascular Events After Exposure to Nilotinib in Chronic Myeloid Leukemia: Long-term Follow-up  Academic Article
• Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis  Academic Article
• Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimen  Academic Article
• Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials  Academic Article
• Circulating Levels of Matrix Gla Protein and Progression of Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial  Academic Article
• Clinical Usefulness of Tissue Doppler Imaging in Patients with Mild to Moderate Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin Study  Academic Article
• Comparison of Rosuvastatin Versus Atorvastatin in South-Asian Patients at Risk of Coronary Heart Disease (from the IRIS Trial)  Academic Article
• Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors  Academic Article
• Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium  Academic Article
• Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib  Academic Article
• Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia  Academic Article
• Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors  Academic Article
• Early high-dose rosuvastatin prevented contrast-induced acute kidney injury in non–ST-elevation ACS  Academic Article
• Early tumor shrinkage is independently associated with improved overall survival among patients with metastatic renal cell carcinoma: a validation study using the COMPARZ cohort  Academic Article
• Effect in vitro on platelet function of two compounds developed from the pyrimido-pyrimidines  Academic Article
• Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia  Academic Article
• Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis  Academic Article
• Effect of RA233 on Platelet Function In Vitro  Academic Article
• Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis  Academic Article
• Effect of tofacitinib withdrawal and re-treatment on patient-reported outcomes: results from a Phase 3 study in patients with moderate to severe chronic plaque psoriasis  Academic Article
• Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction  Academic Article
• Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial  Academic Article
• Efficacy and safety of tofacitinib dose de-escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open  Academic Article
• Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer  Academic Article
• Energy-stress-mediated AMPK activation inhibits ferroptosis  Academic Article
• Esophageal gastrointestinal stromal tumor: report of 7 patients  Academic Article
• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Academic Article
• Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma  Academic Article
• Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials  Academic Article
• Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open‐label study  Academic Article
• High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells  Academic Article
• Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study  Academic Article
• Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties  Academic Article
• Identification and Biochemical Studies on Novel Non-Nucleoside Inhibitors of the Enzyme Adenosine Kinase  Academic Article
• Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET  Academic Article
• Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study  Academic Article
• Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin  Academic Article
• Imatinib mesylate in children and adolescents with cancer  Academic Article
• Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development  Academic Article
• Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups  Academic Article
• Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis  Academic Article
• Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors  Academic Article
• Influence of Cleavage Site on Global Folding of an RNA-Cleaving DNAzyme  Academic Article
• Insulin Resistance and LVH Progression in Patients With Calcific Aortic Stenosis  Academic Article
• Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors  Academic Article
• International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction  Academic Article
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Academic Article
• Letter: corticosteroid use alongside tofacitinib in OCTAVE Open. Authors' reply  Academic Article
• Lipid lowering for primary prevention  Academic Article
• Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia  Academic Article
• Long‐term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program  Academic Article
• Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension  Academic Article
• Mapping the Sinorhizobium meliloti 1021 solute-binding protein-dependent transportome  Academic Article
• Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants  Academic Article
• Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma  Academic Article
• Meteorites and the RNA World: A Thermodynamic Model of Nucleobase Synthesis within Planetesimals  Academic Article
• Milvexian for the Prevention of Venous Thromboembolism  Academic Article
• Modulation of postdecapitation convulsions in rats by α-adrenergic and 5-hydroxytryptamine1A agents  Academic Article
• Multiple Fungal Brain Abscesses in a Child with Acute Lymphoblastic Leukemia  Academic Article
• Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine  Academic Article
• Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure  Academic Article
• P2Y₂ Receptor Up-Regulation Induced by Guanosine or UTP in Rat Brain Cultured Astrocytes  Academic Article
• Patterns of Ruxolitinib Therapy Failure and Its Management in Myelofibrosis: Perspectives of the Canadian Myeloproliferative Neoplasm Group  Academic Article
• Physician- and Patient-reported Effectiveness Are Similar for Tofacitinib and TNFi in Rheumatoid Arthritis: Data From a Rheumatoid Arthritis Registry  Academic Article
• Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease  Academic Article
• Prevalence of endoscopic improvement and remission according to patient-reported outcomes in ulcerative colitis  Academic Article
• Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells  Academic Article
• Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis  Academic Article
• Riociguat for the treatment of pulmonary hypertension  Academic Article
• Riociguat: A Novel Therapeutic Option for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension  Academic Article
• Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4  Academic Article
• Risk of hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive patients with myeloproliferative neoplasms treated with ruxolitinib  Academic Article
• SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension  Academic Article
• Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma  Academic Article
• Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available  Academic Article
• Sensitivity of multiple life stages of 2 freshwater mussel species (Unionidae) to various pesticides detected in Ontario (Canada) surface waters  Academic Article
• Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats  Academic Article
• Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance  Academic Article
• Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results  Academic Article
• Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial  Academic Article
• TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state  Academic Article
• Targeted therapy for metastatic renal cell carcinoma  Academic Article
• Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer  Academic Article
• The Peroxisome Proliferator Response Element of the Gene Encoding the Peroxisomal β-Oxidation Enzyme Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase Is a Target for Constitutive Androstane Receptor β/9-cis-Retinoic Acid Receptor-mediated Transactivation  Academic Article
• The endothelin 1a receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein–carotid artery interposition grafts  Academic Article
• The ground state of embryonic stem cell self-renewal  Academic Article
• The impact of ruxolitinib on thrombosis in patients with polycythemia vera and myelofibrosis  Academic Article
• The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis  Academic Article
• The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase  Academic Article
• Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia  Academic Article
• Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline  Academic Article
• Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study  Academic Article
• Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4.  Academic Article
• Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis  Academic Article
• Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist  Academic Article
• Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma  Academic Article
• Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases  Academic Article
• Use of the Dual Potential to Rationalize the Occurrence of Some DNA Lesions (Pyrimidic Dimers)  Academic Article
• Vericiguat reduced a composite of CV death or HF hospitalization in patients with HF and reduced LVEF  Academic Article
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors  Conference Paper
• hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process  Academic Article
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Academic Article