selected scholarly activity
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academic article
- Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses. Translational Oncology. 14:101209-101209. 2021
- Tyrosine Kinase Inhibitor Therapy in Unresectable Locally Advanced NSCLC: Keep Holding Our Breaths or Time to Take a Breather?. Journal of Thoracic Oncology. 16:1607-1609. 2021
- Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer. JAMA Oncology. 7:1324-1324. 2021
- Metformin in Combination With Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer. JAMA Oncology. 7:1333-1333. 2021
- A Randomized Phase II Trial of Prostate Boost Irradiation With Stereotactic Body Radiotherapy (SBRT) or Conventional Fractionation (CF) External Beam Radiotherapy (EBRT) in Locally Advanced Prostate Cancer: The PBS Trial (NCT03380806). Clinical Genitourinary Cancer. 18:e410-e415. 2020
- Overall and chemotherapy‐free survival following stereotactic body radiation therapy for abdominopelvic oligometastases. Australasian Radiology Journal of Medical Imaging and Radiation Oncology. 64:563-569. 2020
- Summary of international recommendations in 23 languages for patients with cancer during the COVID-19 pandemic. The Lancet Oncology. 21:759-760. 2020
- Patient and family support in the era of fake e-medicine: food for thought from an international consensus panel. ESMO Open. 5:e000696-e000696. 2020
- Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial. The Lancet Oncology. 20:1531-1543. 2019
- Salicylate enhances the response of prostate cancer to radiotherapy. Prostate. 79:489-497. 2019
- Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. Cell Metabolism. 29:174-182.e5. 2019
- AMPK β1 reduces tumor progression and improves survival in p53 null mice. Molecular Oncology. 11:1143-1155. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials. Oncotarget. 8:57733-57754. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- A Novel Neoadjuvant Therapy for Operable Locally Invasive Non–Small-Cell Lung Cancer. Phase I Study of Neoadjuvant Stereotactic Body Radiotherapy. LINNEARRE I (NCT02433574). Clinical Lung Cancer. 18:436-440.e1. 2017
- Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer. Journal of Clinical Oncology. 35:1884-1890. 2017
- Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non–Small-Cell Lung Cancer – Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial. Clinical Lung Cancer. 18:250-254. 2017
- The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Molecular Metabolism. 5:1048-1056. 2016
- Metformin for chemo-radio-sensitization of NSCLC. Radiotherapy and Oncology. 120:363-364. 2016
- 84P Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. 11:S91-S91. 2016
- A Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation for Patients With Non–Small-Cell Lung Cancer. Clinical Lung Cancer. 17:142-149. 2016
- Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism: Clinical and Experimental. 65:124-139. 2016
- Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. Biochemical Journal. 469:177-187. 2015
- Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation. Canadian Journal of Applied Physiology Applied Physiology, Nutrition and Metabolism. 40:407-413. 2015
- Inhibition of human lung cancer cell proliferation and survival by wine. Cancer Cell International. 14:6. 2014
- AMP-activated protein kinase (AMPK) beyond metabolism. Cancer Biology and Therapy. 15:156-169. 2014
- Predicting 2-Year Survival for Radiation Regimens in Advanced Non-small Cell Lung Cancer. Clinical Oncology Comparative Haematology International. 25:697-705. 2013
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. British Journal of Cancer. 108:2021-2032. 2013
- Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiation Oncology. 7:71. 2012
- Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells. Radiotherapy and Oncology. 102:459-465. 2012
- Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells. PLoS ONE. 7:e32035-e32035. 2012
- Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer. 11:56. 2011
- Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiation Oncology. 6:144. 2011
- Lovastatin Sensitizes Lung Cancer Cells to Ionizing Radiation: Modulation of Molecular Pathways of Radioresistance and Tumor Suppression. Journal of Thoracic Oncology. 6:439-450. 2011
- Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells. International Journal of Radiation Oncology Biology Physics. 78:221-229. 2010
- Association of Phosphorylated Epidermal Growth Factor Receptor with Survival in Patients with Locally Advanced Non-small Cell Lung Cancer Treated with Radiotherapy. Journal of Thoracic Oncology. 3:716-722. 2008
- Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells. Biochemical and Biophysical Research Communications. 288:205-211. 2001
- Role of the actin cytoskeleton in insulin action. Microscopy Research and Technique. 47:79-92. 1999
- Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochemical Journal. 341:861-863. 1999
- Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression. Journal of Biological Chemistry. 273:28322-28331. 1998
- Correction: Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose-transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes (Biochemical Journal (1998) 331 (917-928)). Biochemical Journal. 333:848. 1998
- Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry. 271:19664-19667. 1996
- Exercise increases the plasma membrane content of the Na+ -K+ pump and its mRNA in rat skeletal muscles. Journal of Applied Physiology Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 80:699-705. 1996
- Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action. Biochemical Journal. 309:1-5. 1995
- Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.. Journal of Biological Chemistry. 269:29934-29942. 1994
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conference paper
- A Phase 3, Multicenter, Randomized Trial to Evaluate the Symptomatic and Quality of Life Improvements in Lung Cancer Patients Receiving External Beam Radiation With or Without High Dose Rate Intraluminal Brachytherapy. International Journal of Radiation Oncology Biology Physics. S116-S116. 2017
- Comparison of Fiducial Marker Implantation and Soft Tissue Registration Using Cone Beam CT in Image-Guided Radiation Therapy of the Prostate. International Journal of Radiation Oncology Biology Physics. E722-E722. 2017
- Randomized Study of Quality of Life in Patients with High-Risk Prostate Cancer Undergoing Radiotherapy: Role of Pelvic Nodal IMRT. International Journal of Radiation Oncology Biology Physics. E211-E212. 2017
- Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. S91-S91. 2016
- Early Results of a Quality Assurance Program in a Randomized Trial of Stereotactic Body Radiotherapy for Stage I Medically Inoperable Lung Cancer. Journal of Thoracic Oncology. S327-S327. 2015
- Pulmonary Function Test and Its Predictive Factors in Patients With Lung Malignancies Treated With Stereotactic Radiation Therapy: A Retrospective Review From a Single Institution. International Journal of Radiation Oncology Biology Physics. S550-S550. 2013
- THE ANTI-DIABETIC DRUG METFORMIN SENSITIZES HUMAN NON-SMALL CELL LUNG CANCER (NSCLC) XENOGRAFTS TO IONIZING RADIATION.. Journal of Thoracic Oncology. S571-S572. 2011
- A randomized phase III trial of magic mouthwash and sucralfate versus benzydamine hydrochloride for prophylaxis of radiation-induced oral mucositis in head and neck cancer.. Journal of Clinical Oncology. 5521-5521. 2011
- Abstract 2491: Metformin sensitizes human lung cancer xenografts to ionizing radiation: Response of the AMPK pathway. Cancer Research. 2011
- Abstract 4071: Sestrins modulate the expression of the metabolic stress sensor AMPK in breast cancer cells. Cancer Research. 2011
- Influence of Gold Seed Implantation on Defining Target Volumes for Conformal Radiotherapy of Prostate Cancer. International Journal of Radiation Oncology Biology Physics. S322-S322. 2008
- Plasma membrane and cytoplasmic activated EGF receptor predicts survival and cytoplasmic activated Erk predicts tumour response in locally advanced NSCLC patients treated with chemo-radiotherapy. Radiotherapy and Oncology. S57-S57. 2007
- P-126 Activation of tyrosine kinase receptors and intracellular signal mediators in NSCLC tumors. Lung Cancer. S148-S148. 2005
- Mitogen-activated protein kinase (MAPK) expression and activation in non-small cell lung cancer (NSCLC): Investigating their prognostic significance and role in radiation responses.. Radiotherapy and Oncology. S40-S41. 2004
- Alternative pathways of MAP kinase activation by tyrosine kinase receptors.. FASEB Journal. A194-A194. 1998
- Involvement of the actin network in insulin signalling.. Society of General Physiologists Series. 257-271. 1997