selected scholarly activity
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academic article
- AMPK β1 reduces tumor progression and improves survival in p53 null mice.. Molecular Oncology. 11:1143-1155. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- A Novel Neoadjuvant Therapy for Operable Locally Invasive Non-Small-Cell Lung Cancer. Phase I Study of Neoadjuvant Stereotactic Body Radiotherapy. LINNEARRE I (NCT02433574).. Clinical Lung Cancer. 18:436-440.e1. 2017
- Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer.. Journal of Clinical Oncology. 35:1884-1890. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy; translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non-Small-Cell Lung Cancer - Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial.. Clinical Lung Cancer. 18:250-254. 2017
- The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration.. Molecular Metabolism. 5:1048-1056. 2016
- Metformin for chemo-radio-sensitization of NSCLC.. Radiotherapy and Oncology. 120:363-364. 2016
- 84P Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside.. Journal of Thoracic Oncology. 11:S91. 2016
- A Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation for Patients With Non-Small-Cell Lung Cancer.. Clinical Lung Cancer. 17:142-149. 2016
- Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment.. Metabolism: Clinical and Experimental. 65:124-139. 2016
- Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.. Biochemical Journal. 469:177-187. 2015
- Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation.. Canadian Journal of Applied Physiology Applied Physiology, Nutrition and Metabolism. 40:407-413. 2015
- AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway.. Cancer Biology and Therapy. 15:156-169. 2014
- Inhibition of human lung cancer cell proliferation and survival by wine.. Cancer Cell International. 14:6. 2014
- Predicting 2-year survival for radiation regimens in advanced non-small cell lung cancer.. Clinical Oncology Comparative Haematology International. 25:697-705. 2013
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.. British Journal of Cancer. 108:2021-2032. 2013
- Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts.. Radiation Oncology. 7:71. 2012
- Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival.. Radiotherapy and Oncology. 102:459-465. 2012
- Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.. PLoS ONE. 7:e32035. 2012
- Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.. Radiation Oncology. 6:144. 2011
- Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression.. Journal of Thoracic Oncology. 6:439-450. 2011
- Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells.. BMC Cancer. 11:56. 2011
- Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.. International Journal of Radiation Oncology Biology Physics. 78:221-229. 2010
- Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.. Journal of Thoracic Oncology. 3:716-722. 2008
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conference paper
- A Phase 3, Multicenter, Randomized Trial to Evaluate the Symptomatic and Quality of Life Improvements in Lung Cancer Patients Receiving External Beam Radiation With or Without High Dose Rate Intraluminal Brachytherapy. International Journal of Radiation Oncology Biology Physics. S116-S116. 2017
- Comparison of Fiducial Marker Implantation and Soft Tissue Registration Using Cone Beam CT in Image-Guided Radiation Therapy of the Prostate. International Journal of Radiation Oncology Biology Physics. E722-E722. 2017
- Randomized Study of Quality of Life in Patients with High-Risk Prostate Cancer Undergoing Radiotherapy: Role of Pelvic Nodal IMRT. International Journal of Radiation Oncology Biology Physics. E211-E212. 2017
- Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. S91-S91. 2016
- Early Results of a Quality Assurance Program in a Randomized Trial of Stereotactic Body Radiotherapy for Stage I Medically Inoperable Lung Cancer. Journal of Thoracic Oncology. S327-S327. 2015
- Pulmonary Function Test and Its Predictive Factors in Patients With Lung Malignancies Treated With Stereotactic Radiation Therapy: A Retrospective Review From a Single Institution. International Journal of Radiation Oncology Biology Physics. S550-S550. 2013
- THE ANTI-DIABETIC DRUG METFORMIN SENSITIZES HUMAN NON-SMALL CELL LUNG CANCER (NSCLC) XENOGRAFTS TO IONIZING RADIATION.. Journal of Thoracic Oncology. S571-S572. 2011
- A randomized phase III trial of magic mouthwash and sucralfate versus benzydamine hydrochloride for prophylaxis of radiation-induced oral mucositis in head and neck cancer.. Journal of Clinical Oncology. 2011
- Metformin sensitizes human lung cancer xenografts to ionizing radiation: Response of the AMPK pathway. Cancer Research. 2011
- Sestrins modulate the expression of the metabolic stress sensor AMPK in breast cancer cells. Cancer Research. 2011
- Influence of gold seed implantation on defining target volumes for conformal radiotherapy of prostate cancer. International Journal of Radiation Oncology Biology Physics. S322-S323. 2008
- Plasma membrane and cytoplasmic activated EGF receptor predicts survival and cytoplasmic activated Erk predicts tumour response in locally advanced NSCLC patients treated with chemo-radiotherapy. Radiotherapy and Oncology. S57-S57. 2007
- Activation of tyrosine kinase receptors and intracellular signal mediators in NSCLC tumors. Lung Cancer. S148-S148. 2005
- Mitogen-activated protein kinase (MAPK) expression and activation in non-small cell lung cancer (NSCLC): Investigating their prognostic significance and role in radiation responses.. Radiotherapy and Oncology. S40-S41. 2004
- Alternative pathways of MAP kinase activation by tyrosine kinase receptors.. FASEB Journal. A194-A194. 1998