selected scholarly activity
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academic article
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- A Novel Neoadjuvant Therapy for Operable Locally Invasive Non-Small-Cell Lung Cancer. Phase I Study of Neoadjuvant Stereotactic Body Radiotherapy. LINNEARRE I (NCT02433574).. Clinical Lung Cancer. 18:436-440.e1. 2017
- Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy; translational biology and rationale for current clinical trials.. Oncotarget. 8:57733-57754. 2017
- Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non-Small-Cell Lung Cancer - Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial.. Clinical Lung Cancer. 18:250-254. 2017
- Quality of life and swallowing with standard chemoradiotherapy versus accelerated radiotherapy and panitumumab in locoregionally advanced carcinoma of the head and neck: A phase III randomised trial from the Canadian Cancer Trials Group (HN.6).. European Journal of Cancer. 72:192-199. 2017
- Effect of Standard Radiotherapy With Cisplatin vs Accelerated Radiotherapy With Panitumumab in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma: A Randomized Clinical Trial.. JAMA Oncol. 3:220-226. 2016
- Metformin for chemo-radio-sensitization of NSCLC.. Radiotherapy and Oncology. 120:363-364. 2016
- Management of small-cell lung cancer with radiotherapy-a pan-Canadian survey of radiation oncologists.. Current Oncology. 23:184-195. 2016
- 84P Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside.. Journal of Thoracic Oncology. 11:S91. 2016
- A Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation for Patients With Non-Small-Cell Lung Cancer.. Clinical Lung Cancer. 17:142-149. 2016
- The Technique, Resources and Costs of Stereotactic Body Radiotherapy of Prostate Cancer: A Comparison of Dose Regimens and Delivery Systems.. Technology in Cancer Research and Treatment. 15:171-178. 2016
- 0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced head and neck cancers.. British Journal of Radiology. 88:20140646. 2015
- Phase II study of accelerated hypofractionated three-dimensional conformal radiotherapy for stage T1-3 N0 M0 non-small cell lung cancer: NCIC CTG BR.25.. Journal of the National Cancer Institute. 106. 2014
- Predicting 2-year survival for radiation regimens in advanced non-small cell lung cancer.. Clinical Oncology Comparative Haematology International. 25:697-705. 2013
- Robotic radiosurgery for the treatment of 1-3 brain metastases: a pragmatic application of cost-benefit analysis using willingness-to-pay.. Technology in Cancer Research and Treatment. 12:517-523. 2013
- The technique and cost of radiosurgery for the treatment of 1-3 brain metastases.. Canadian Journal of Neurological Sciences. 40:795-799. 2013
- Performance status and symptom scores of women with gynecologic cancer at the end of life.. International Journal of Gynecological Cancer. 23:971-978. 2013
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.. British Journal of Cancer. 108:2021-2032. 2013
- Patient preferences for oropharyngeal cancer treatment de-escalation. Head and Neck Surgery Head and Neck. 35:151-159. 2013
- In vitro evaluation of the potential for resistance development to ceragenin CSA-13.. Journal of Antimicrobial Chemotherapy. 67:2665-2672. 2012
- Technology resource planning in radiation oncology: application of a needs-based analytic framework to radiosurgery planning in Ontario.. Journal of Oncology Practice. 8:358-362. 2012
- Acute-phase response reactants as objective biomarkers of radiation-induced mucositis in head and neck cancer.. Head and Neck Surgery Head and Neck. 34:985-993. 2012
- Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts.. Radiation Oncology. 7:71. 2012
- Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival.. Radiotherapy and Oncology. 102:459-465. 2012
- Three-year outcomes of a Canadian multicenter study of accelerated partial breast irradiation using conformal radiation therapy.. International Journal of Radiation Oncology Biology Physics. 81:1220-1227. 2011
- Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.. Radiation Oncology. 6:144. 2011
- Prophylactic feeding tubes for patients with locally advanced head-and-neck cancer undergoing combined chemotherapy and radiotherapy-systematic review and recommendations for clinical practice.. Current Oncology. 18:e191-e201. 2011
- Selecting patients with extensive-stage small cell lung cancer for prophylactic cranial irradiation by predicting brain metastases.. Journal of Thoracic Oncology. 6:808-812. 2011
- Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression.. Journal of Thoracic Oncology. 6:439-450. 2011
- Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.. International Journal of Radiation Oncology Biology Physics. 78:221-229. 2010
- A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over.. Leukemia. 23:631-634. 2009
- Comparison of toxicity associated with early morning versus late afternoon radiotherapy in patients with head-and-neck cancer: a prospective randomized trial of the National Cancer Institute of Canada Clinical Trials Group (HN3).. International Journal of Radiation Oncology Biology Physics. 73:166-172. 2009
- In vitro survival of nonsmall cell lung cancer cells following combined treatment with ionizing radiation and photofrin-mediated photodynamic therapy.. Photochemistry and Photobiology. 85:99-106. 2009
- Understanding the results of meta-analyses in the treatment of head and neck squamous cell cancer.. Hematology/Oncology Clinics of North America. 22:1257-x. 2008
- Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.. Journal of Thoracic Oncology. 3:716-722. 2008
- What constitutes a "clinical trial"?: a survey of oncology professionals.. Current Controlled Trials in Cardiovascular Medicine Trials. 9:12. 2008
- Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia.. Journal of Clinical Oncology. 25:1027-1032. 2007
- A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150.. Annals of Oncology. 18:116-121. 2007
- Phase III Trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13.. Journal of Clinical Oncology. 24:2092-2097. 2006
- The importance of reporting patient recruitment details in phase III trials.. Journal of Clinical Oncology. 24:843-845. 2006
- Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors.. The Lancet Oncology. 7:141-148. 2006
- Estimating per patient funding for cancer clinical trials: an Ontario based survey.. Controlled Clinical Trials Contemporary Clinical Trials. 26:421-429. 2005
- The metrics of clinical trials.. Journal of Clinical Oncology. 23:1589-1590. 2005
- Pilot study of the quality initiative in rectal cancer strategy.. Diseases of the Colon and Rectum. 47:1594-1598. 2004
- Radiation induced mucositis: co-ordinating a research agenda.. Clinical Oncology Comparative Haematology International. 15:473-477. 2003
- Researching the cost of research.. Journal of Clinical Oncology. 21:4081-4082. 2003
- Digital necrosis associated with squamous cell carcinoma of the tonsil.. Head and Neck Surgery Head and Neck. 24:1019-1021. 2002
- Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (NCIC CTG SC.15).. International Journal of Radiation Oncology Biology Physics. 54:719-728. 2002
- Factors that influence the recruitment of patients to Phase III studies in oncology: the perspective of the clinical research associate.. Cancer. 95:1584-1591. 2002
- Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis.. Journal of Clinical Oncology. 18:1220-1229. 2000
- Management of ductal carcinoma in situ of the breast. Provincial Breast Cancer Disease Site Group.. Cancer Prevention and Control. 2:312-319. 1998
- Economic analyses.. International Journal of Radiation Oncology Biology Physics. 38:907-908. 1997
- Patient preference for high or low dose rate brachytherapy in carcinoma of the cervix.. Radiotherapy and Oncology. 33:187-194. 1994
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conference paper
- A Phase 3, Multicenter, Randomized Trial to Evaluate the Symptomatic and Quality of Life Improvements in Lung Cancer Patients Receiving External Beam Radiation With or Without High Dose Rate Intraluminal Brachytherapy. International Journal of Radiation Oncology Biology Physics. S116-S116. 2017
- Metabolic stress to sensitize non-small cell lung cancer (NSCLC) to radiotherapy: Studies from bench to bedside. Journal of Thoracic Oncology. S91-S91. 2016
- Acute Toxicity and Quality of Life of Hypofractionated Radiation Therapy for Breast Cancer. International Journal of Radiation Oncology Biology Physics. S59-S59. 2015
- Phase 2 Study of "0-7-21" Hypofractionated Palliative Radiation Therapy for Advanced Head and Neck Squamous Cell Carcinoma. International Journal of Radiation Oncology Biology Physics. S128-S128. 2015
- Early Results of a Quality Assurance Program in a Randomized Trial of Stereotactic Body Radiotherapy for Stage I Medically Inoperable Lung Cancer. Journal of Thoracic Oncology. S327-S327. 2015
- Phase III randomized trial of standard fractionation radiotherapy (SFX) with concurrent cisplatin (CIS) versus accelerated fractionation radiotherapy (AFX) with panitumumab (PMab) in patients (pts) with locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): NCIC Clinical Trials Group HN.6 trial.. Journal of Clinical Oncology. 2015
- Quality of life (QOL) in a phase III randomized trial of standard fractionation radiotherapy (SFX) with concurrent cisplatin (CIS) versus accelerated fractionation radiotherapy (AFX) with panitumumab (PMab) in patients (pts) with locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): NCIC Clinical Trials Group HN.6 (NCT00820248). Journal of Clinical Oncology. 2015
- Metformin to modulate AMP-kinase and enhance chemotherapy and radiotherapy in non-small cell lung cancer. European Journal of Cancer. 67-67. 2014
- 0-7-21 Hypofractionated Palliative Radiation Therapy in Advanced Head-and-Neck Cancers: A Retrospective Study Definitive Management of Head-and-Neck Squamous Cell Carcinoma. International Journal of Radiation Oncology Biology Physics. 476-477. 2014
- A Preliminary Series of the Use of Stereotactic Radiosurgery (SBRT) in High-Risk Head-and-Neck Cancer. International Journal of Radiation Oncology Biology Physics. S429-S430. 2013
- Pulmonary Function Test and Its Predictive Factors in Patients With Lung Malignancies Treated With Stereotactic Radiation Therapy: A Retrospective Review From a Single Institution. International Journal of Radiation Oncology Biology Physics. S550-S550. 2013
- Robotic radiosurgery for the treatment of one to three brain metastases: A pragmatic application of cost-benefit analysis using willingness to pay. Journal of Clinical Oncology. 2012
- A Phase II Study of Accelerated Hypofractionated 3-dimensional Conformal Radiation Therapy for Inoperable T1-3 NO MO Non-small Cell Lung Cancer: NCIC CTG BR.25. International Journal of Radiation Oncology Biology Physics. S47-S48. 2012
- Cardiac Sparing With Breath-hold Technique: A Dosimetric Evaluation of Benefits in Different Patient Populations. International Journal of Radiation Oncology Biology Physics. S257-S257. 2012
- Identifying Risk Factors for Locoregional Recurrence Following Postmastectomy Radiation Therapy. International Journal of Radiation Oncology Biology Physics. S251-S251. 2012
- Retrospective Study of Hypofractionated Palliative Radiation Therapy for Advanced Head-and-Neck Cancers 0-7-21. International Journal of Radiation Oncology Biology Physics. S521-S521. 2012
- A Phase II Study of Accelerated Hypofractionated 3-Dimensional Conformal Radiotherapy for Inoperable T1-3 N0 M0 Non-Small Cell Lung Cancer: NCIC CTG BR.25. Journal of Thoracic Oncology. S210-S211. 2012
- A phase III study of standard fractionation radiotherapy with concurrent high-dose cisplatin versus accelerated fractionation radiotherapy (RT) with panitumumab in patients with locally advanced stage III and IV squamous cell carcinoma of the head and neck (SCCHN) (NCIC Clinical Trials Group HN.6).. Journal of Clinical Oncology. 2012
- AN ONTARIO CLINICAL ONCOLOGY GROUP (OCOG) RANDOMIZED TRIAL (PET START) OF FDG PET/CT IN PATIENTS WITH STAGE 3 NON-SMALL CELL LUNG CANCER (NSCLC): IMPACT OF PET ON RADIATION TREATMENT VOLUMES. Journal of Thoracic Oncology. S428-S428. 2011
- THE ANTI-DIABETIC DRUG METFORMIN SENSITIZES HUMAN NON-SMALL CELL LUNG CANCER (NSCLC) XENOGRAFTS TO IONIZING RADIATION.. Journal of Thoracic Oncology. S571-S572. 2011
- A randomized phase III trial of magic mouthwash and sucralfate versus benzydamine hydrochloride for prophylaxis of radiation-induced oral mucositis in head and neck cancer.. Journal of Clinical Oncology. 2011
- An Ontario Clinical Oncology Group (OCOG) randomized trial (PET START) of FDG PET/CT in patients with stage III non-small cell lung cancer (NSCLC): Predictors of overall survival.. Journal of Clinical Oncology. 2011
- Metformin sensitizes human lung cancer xenografts to ionizing radiation: Response of the AMPK pathway. Cancer Research. 2011
- An Ontario Clinical Oncology (OCOG) Randomized Trial (PET START) of FDG PET/CT in Stage 3 Non-small Cell Lung Cancer (NSCLC): Impact of PET on Survival. International Journal of Radiation Oncology Biology Physics. S137-S137. 2011
- A phase II trial of the Src kinase inhibitor AZD0530 in patients with metastatic or locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma: A trial of the PMH phase II consortium. Journal of Clinical Oncology. 2010
- Management change as a result of positron emission tomography (PET) in a prospective randomized clinical trial. Journal of Thoracic Oncology. S746-S746. 2009
- Impact of positron emission tomography (PET) in stage III non-small cell lung cancer (NSCLC): A prospective randomized trial (PET START). Journal of Clinical Oncology. 2009
- A RETROSPECTIVE REVIEW OF THE INCIDENCE OF BRAIN METASTASES IN PATIENTS WITH EXTENSIVE STAGE SMALL CELL LUNG CANCER. Neuro-Oncology. 844-844. 2008
- The validity and reliability of a parent-child dyad approach to utility and quality-of-life assessment in children. Value in Health. A14-A14. 2008
- Immunohistochemistry for phosphorylated EGF receptor predicts survival and phosphorylated ERK predicts tumor response to chemo-radiotherapy in unresectable, locally advanced non-small cell lung cancer patients. Laboratory Investigation. 339A-339A. 2008
- Immunohistochemistry for phosphorylated EGF receptor predicts survival and phosphorylated ERK predicts tumor response to chemoradiotherapy in unresectable, locally advanced non-small cell lung cancer patients. Modern Pathology. 339A-339A. 2008
- Results of a prospective study on brachytherapy in lung cancer in combination with other modalities. International Journal of Radiation Oncology Biology Physics. S440-S441. 2008
- Plasma membrane and cytoplasmic activated EGF receptor predicts survival and cytoplasmic activated Erk predicts tumour response in locally advanced NSCLC patients treated with chemo-radiotherapy. Radiotherapy and Oncology. S57-S57. 2007
- Acute phase response reactants as an objective measure of mucosal toxicity in head and neck cancer patients undergoing radical radiation therapy with or without concurrent chemo-therapy. Radiotherapy and Oncology. S3-S3. 2006
- Initial results of a Canadian feasibility study of accelerated partial breast irradiation (APBI) using 3-D conformal radiation therapy (3D CRT). Radiotherapy and Oncology. S16-S16. 2006
- Inter-observer variability in gross tumour volume delineation in locally advanced non-small cell lung cancer cases: An institutional review. Radiotherapy and Oncology. S38-S38. 2006
- Research and professional development: Video/Phone conference as a format for advancements in palliative radiotherapy. Radiotherapy and Oncology. S59-S59. 2006
- The impact of positron emission tomography (PET) in stage III non-small cell lung cancer: A prospective randomized clinical trial-improving clinical trials accrual using screening log evaluations. Radiotherapy and Oncology. S49-S49. 2006
- Bortezomib is active in Waldenstrom's Macroglobulinemia (WM) - Results of a National Cancer Institute of Canada (NCIC) phase II study in previously untreated or treated WM.. Journal of Clinical Oncology. 432S-432S. 2006
- Acute phase response reactants as an objective measure of mucosal toxicity in head and neck cancer patients undergoing radical radiation therapy with or without concurrent chemotherapy. International Journal of Radiation Oncology Biology Physics. S436-S436. 2006
- Inflammatory serum markers as an objective measure of radiation mucositis in head and neck cancer. Radiotherapy and Oncology. S41-S41. 2005
- Activation of tyrosine kinase receptors and intracellular signal mediators in NSCLC tumors. Lung Cancer. S148-S148. 2005
- Why cancer patients enter randomized clinical trials: exploring the factors that influence their decision.. Journal of Clinical Oncology. 4312-4318. 2004
- A study examining epidermal growth factor receptor, p53, and Bcl-2 expression in patients with locally advanced squamous cell carcinoma of the head and neck treated with concomitant chemoradiotherapy. Lung Cancer. S82-S83. 2004
- Evaluation of inflammatory serum proteins as an objective measure of radiation induced mucositis in patients receiving radical radiation with or without concurrent chemotherapy. Radiotherapy and Oncology. S385-S386. 2004
- 'There is nothing so practical as a good theory': modelling the cortical effects of general anaesthesia. British Journal of Anaesthesia. 483P-484P. 2004
- A study examining epidermal growth factor receptor, p53, and Bcl-2 expression in patients with stage III and IV squamous cell carcinoma of the head and neck treated with concomitant chemo-radiotherapy.. Radiotherapy and Oncology. S40-S40. 2004
- Mitogen-activated protein kinase (MAPK) expression and activation in non-small cell lung cancer (NSCLC): Investigating their prognostic significance and role in radiation responses.. Radiotherapy and Oncology. S40-S41. 2004
- Thyroid function screening following radiation therapy for cancers of the head and neck: A survey of Canadian practice patterns. Radiotherapy and Oncology. S48-S48. 2004
- The pilot project of the quality initiative in rectal cancer (QIRC) Strategy. Annals of Surgical Oncology. S22-S23. 2002