selected scholarly activity
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conferences
- Deep Mutational Scan of VWF to Define Mutations that Enhance or Impair Secretion. Thrombosis Research. 9-9. 2019
- Investigating the resistance of ADAMTS13 towards Alpha 2-Macroglobulin. Thrombosis Research. 8-8. 2019
- Mapping the Interactome of the Metalloprotease ADAMTS13 in Plasma using In-Vitro BioID. Thrombosis Research. 6-7. 2019
- Development of Platforms to Phenotype Variants of Uncertain Significance in VWF. Blood. 1386-1386. 2016
- Platelet Phosphatidylserine Exposure, Survival and Blood Coagulation in Mice Lacking TMEM16F. Blood. 2015
- Exosite interactions uncover a broad substrate recognition profile for ADAMTS13. Journal of Thrombosis and Haemostasis. 234-234. 2015
- TMEM16F Deficiency Causes a Strain-Dependent Lethality in Mice and Reduced Phosphatidylserine Exposure on Heterozygous As Well As Homozygous Deficient Mouse Platelets. Blood. 2014
- A Zebrafish Model Of Antithrombin III Deficiency Displays Bleeding and Thrombosis Secondary To Disseminated Intravascular Coagulation. Blood. 200-200. 2013
- A comprehensive mutagenesis screen defines the substrate recognition landscape within VWF for ADAMTS13. Journal of Thrombosis and Haemostasis. 122-122. 2013
- Prothrombin activation intermediates bind thrombomodulin demonstrating sequential capacitation of exosite 1. Journal of Thrombosis and Haemostasis. 193-193. 2013
- Partial in Vivo FVIII Stabilization by VWF Fragments. Blood. 15-15. 2012
- SAR development and target identification studies on a class of novel bacterial virulence inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012
- Virulence-attenuating inhibitors of streptokinase (SK) expression in Group A streptococcus (GAS): Activity optimization and target identification. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2011
- Probing the determinants of VWF substrate specificity for ADAMTS13 by M13 filamentous phage display. Journal of Thrombosis and Haemostasis. 455-456. 2011
- Thrombin Aptamer HD1 Inhibits Prothrombin Activation by Binding Proexosite 1 on Prothrombin.. Blood. 1950-1950. 2005
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journal articles
- A specific fluorescence resonance energy quenching–based biosensor for measuring thrombin activity in whole blood. Journal of Thrombosis and Haemostasis. 22:1627-1639. 2024
- Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13. Scientific Reports. 14:9073. 2024
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Past meets present: Reviving 80‐year‐old Canadian dried serum from World War
II and its significance in advancing modern freeze‐dried plasma for prehospital management of haemorrhage. British Journal of Haematology. 204:1515-1522. 2024 - Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis. Intensive Care Medicine Experimental. 12:28. 2024
- REVIEWING THE DYSREGULATION OF ADAMTS13 AND VWF IN SEPSIS. Shock. 61:189-196. 2024
- Metalloprotease domain latency protects ADAMTS13 against broad-spectrum inhibitors of metalloproteases while maintaining activity toward VWF. Journal of Thrombosis and Haemostasis. 21:1789-1801. 2023
- Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition. Journal of Biological Chemistry. 298:102608-102608. 2022
- Mechanisms of ADAMTS13 regulation. Journal of Thrombosis and Haemostasis. 20:2722-2732. 2022
- Identification of the histidine‐rich glycoprotein domains responsible for contact pathway inhibition. Journal of Thrombosis and Haemostasis. 20:821-832. 2022
- A Micro-lyse goes a long way. Blood. 139:477-479. 2022
- Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape. Scientific Reports. 11:18827. 2021
- Illustrated State‐of‐the‐Art Capsules of the ISTH 2021 Congress. Research and Practice in Thrombosis and Haemostasis. 5:e12532-e12532. 2021
- Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: A single‐center prospective longitudinal study. Journal of Thrombosis and Haemostasis. 19:1546-1557. 2021
- Diagnostic Potential of Coagulation-Related Biomarkers for Sepsis in the Emergency Department: Protocol for a Pilot Observational Cohort Study. Critical Care Explorations. 3:e0414-e0414. 2021
- Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients. PLoS ONE. 16:e0247017-e0247017. 2021
- Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish. Scientific Reports. 10:4049. 2020
- High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13. Scientific Reports. 8:2788. 2018
- Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels. Blood Advances. 1:1037-1046. 2017
- Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis. Methods in molecular biology (Clifton, N.J.). 1579:209-228. 2017
- Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII. Blood. 126:939-942. 2015
- Corrigendum to “Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage”. Advances in Hematology. 2015:1-1. 2015
- Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13. Proceedings of the National Academy of Sciences of the United States of America. 112:9328-9333. 2015
- Modeling Disorders of Blood Coagulation in the Zebrafish. Current Pathobiology Reports. 3:155-161. 2015
- HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.. Journal of Biological Chemistry. 290:4813-4813. 2015
- Long range communication between exosites 1 and 2 modulates thrombin function.. Journal of Biological Chemistry. 290:4814-4814. 2015
- Probing ADAMTS13 Substrate Specificity using Phage Display. PLoS ONE. 10:e0122931-e0122931. 2015
- A von Willebrand factor fragment containing the D′D3 domains is sufficient to stabilize coagulation factor VIII in mice. Blood. 124:445-452. 2014
- Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Blood. 124:142-150. 2014
- Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents. Bioorganic and Medicinal Chemistry Letters. 24:1538-1544. 2014
- von Willebrand Factor: Form for Function. Seminars in Thrombosis and Hemostasis. 40:017-027. 2014
- A Protease TAMER: a nucleic acid‐based anticoagulant. Journal of Thrombosis and Haemostasis. 10:867-869. 2012
- Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage. Advances in Hematology. 2012:1-9. 2012
- Tissue Factor and Thrombosis Models. Arteriosclerosis, Thrombosis and Vascular Biology. 30:900-908. 2010
- HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions. Thrombosis and Haemostasis. 103:83-96. 2010
- Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function. Journal of Biological Chemistry. 284:25620-25629. 2009
- HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase. Journal of Biological Chemistry. 281:37477-37485. 2006