publication venue for
- Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. 31:760-775.e17. 2024
- Discovery of antibiotics that selectively kill metabolically dormant bacteria. 31:712-728.e9. 2024
- Chemical genomics reveals targetable programs of human cancers rooted in pluripotency. 30:780-794.e8. 2023
- A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. 29:840-853.e6. 2022
- Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria. 28:1703-1715.e11. 2021
- Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. 28:1394-1406.e10. 2021
- Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics. 27:1544-1552.e3. 2020
- Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence. 27:793-805.e7. 2020
- Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance. 26:1333-1334. 2019
- Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy. 26:17-26.e13. 2019
- Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. 25:403-412.e5. 2018
- B. subtilis LytR-CpsA-Psr Enzymes Transfer Wall Teichoic Acids from Authentic Lipid-Linked Substrates to Mature Peptidoglycan In Vitro. 24:1537-1546.e4. 2017
- Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. 24:1205-1215.e3. 2017
- Sam68 Allows Selective Targeting of Human Cancer Stem Cells. 24:833-844.e9. 2017
- A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. 24:493-506.e5. 2017
- A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. 24:98-109. 2017
- Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. 23:1383-1394. 2016
- Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity. 23:267-277. 2016
- Exploration of Nonribosomal Peptide Families with an Automated Informatic Search Algorithm. 22:1259-1269. 2015
- Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. 22:705-711. 2015
- Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK. 21:866-879. 2014
- Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling. 21:619-627. 2014
- Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis. 21:136-145. 2014
- Exploring Intermolecular Interactions of a Substrate Binding Protein Using a Riboswitch-Based Sensor. 20:1502-1512. 2013
- A Cryptic Polyene Biosynthetic Gene Cluster in Streptomyces calvus Is Expressed upon Complementation with a Functional bldA Gene. 20:1214-1224. 2013
- Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus. 20:1168-1178. 2013
- Self Resistance to the Atypical Cationic Antimicrobial Peptide Edeine of Brevibacillus brevis Vm4 by the N-Acetyltransferase EdeQ. 20:983-990. 2013
- Fluorogenic Probe for Constitutive Cellular Endocytosis. 20:614-618. 2013
- Bacterial Inactivation of the Anticancer Drug Doxorubicin. 19:1255-1264. 2012
- Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism. 19:1020-1027. 2012
- Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors. 19:1041-1048. 2012
- Antibiotics: A New Hope. 19:3-10. 2012
- A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome. 18:1591-1601. 2011
- Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP. 17:959-969. 2010
- Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity. 17:852-862. 2010
- Using a Riboswitch Sensor to Examine Coenzyme B12 Metabolism and Transport in E. coli. 17:756-765. 2010
- Chemical Genomic Approaches to Study Model Microbes. 17:624-632. 2010
- Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis. 16:548-556. 2009
- Structure and Function of the Glycopeptide N-methyltransferase MtfA, a Tool for the Biosynthesis of Modified Glycopeptide Antibiotics. 16:401-410. 2009
- Biologically Inspired Synthetic Enzymes Made from DNA. 16:311-322. 2009
- Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE. 15:1287-1295. 2008
- Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes. 15:1220-1230. 2008
- Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis. 15:501-512. 2008
- Aptamers and Small Molecules Play Tug of War. 14:736-738. 2007
- High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones. 14:153-164. 2007
- Evolution of High-Branching Deoxyribozymes from a Catalytic DNA with a Three-Way Junction. 13:1061-1069. 2006
- An In Vitro Screen of Bacterial Lipopolysaccharide Biosynthetic Enzymes Identifies an Inhibitor of ADP-Heptose Biosynthesis. 13:437-441. 2006
- AEG3482 Is an Antiapoptotic Compound that Inhibits Jun Kinase Activity and Cell Death through Induced Expression of Heat Shock Protein 70. 13:213-223. 2006
- Biosynthesis of Sulfated Glycopeptide Antibiotics by Using the Sulfotransferase StaL. 13:171-181. 2006
- Investigating β-Hydroxyenduracididine Formation in the Biosynthesis of the Mannopeptimycins. 12:1163-1168. 2005
- Chimeric Streptogramin-Tyrocidine Antibiotics that Overcome Streptogramin Resistance. 12:229-235. 2005
- High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase. 11:1445-1453. 2004
- Multicopy Suppressors for Novel Antibacterial Compounds Reveal Targets and Drug Efflux Susceptibility. 11:1423-1430. 2004
- Dual Effects of MLS Antibiotics. 11:1307-1316. 2004
- Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme. 11:57-67. 2004
- Sequence Diversity, Metal Specificity, and Catalytic Proficiency of Metal-Dependent Phosphorylating DNA Enzymes. 9:507-517. 2002
- Prodigious substrate specificity of AAC(6′)-APH(2′'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. 6:99-110. 1999
- Aminoglycoside antibiotic phosphotransferases are also serine protein kinases. 6:11-18. 1999
- DNA-enhanced peroxidase activity of a DNA aptamer-hemin complex. 5:505-517. 1998
- The modus operandi of a DNA enzyme: enhancement of substrate basicity. 5:1-12. 1998
- Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue. 3:747-755. 1996
- A non-canonical base pair within the human immunodeficiency virus Rev-responsive element is involved in both Rev and small molecule recognition. 3:129-137. 1996