Journal article
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
Abstract
Overlapping principles of embryonic and tumor biology have been described, with recent multi-omics campaigns uncovering shared molecular profiles between human pluripotent stem cells (hPSCs) and adult tumors. Here, using a chemical genomic approach, we provide biological evidence that early germ layer fate decisions of hPSCs reveal targets of human cancers. Single-cell deconstruction of hPSCs-defined subsets that share transcriptional patterns …
Authors
Orlando L; Benoit YD; Reid JC; Nakanishi M; Boyd AL; García-Rodriguez JL; Tanasijevic B; Doyle MS; Luchman A; Restall IJ
Journal
Cell Chemical Biology, Vol. 30, No. 7, pp. 780–794.e8
Publisher
Elsevier
Publication Date
7 2023
DOI
10.1016/j.chembiol.2023.06.004
ISSN
2451-9456