Journal article
DNA-enhanced peroxidase activity of a DNA aptamer-hemin complex
Abstract
BACKGROUND: In vitro selection (SELEX) previously identified short single-stranded DNAs that specifically bound N-methylmesoporphyrin IX (NMM), a stable transition-state analogue for porphyrin-metallation reactions. Interestingly, iron(III)-protoporphyrin (hemin) was a good competitive inhibitor for the DNA-catalyzed metallation reaction, and appeared to bind strongly to the NMM-binding DNA aptamers. We investigated the peroxidase activity of …
Authors
Travascio P; Li Y; Sen D
Journal
Cell Chemical Biology, Vol. 5, No. 9, pp. 505–517
Publisher
Elsevier
Publication Date
September 1998
DOI
10.1016/s1074-5521(98)90006-0
ISSN
2451-9456