Tissue Plasminogen Activator
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A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator Academic Article
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A New Short Infusion Dosage Regimen of Recombinant Tissue Plasminogen Activator in Patients with Venous Thromboembolic Disease Academic Article
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A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage Academic Article
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A Randomized Trial of a Single Bolus Dosage Regimen of Recombinant Tissue Plasminogen Activator in Patients with Acute Pulmonary Embolism Academic Article
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ASPIRIN AND FIBRINOLYSIS Academic Article
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Activated Partial Thromboplastin Time and Outcome After Thrombolytic Therapy for Acute Myocardial Infarction Academic Article
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Activated thrombin‐activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin‐dependent plasmin generation on thrombin‐activated platelets Academic Article
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Acute Ischemic Stroke Therapy Overview Academic Article
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Acute stroke management. Academic Article
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Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis. Academic Article
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An Economic Evaluation of rt-PA Locking Solution in Dialysis Catheters Academic Article
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An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction Academic Article
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Antithrombotic and thrombolytic therapy for ischemic stroke: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Academic Article
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Aspirin and fibrinolysis in acute myocardial infarction: Meta-analytic evidence for synergy Academic Article
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Aspirin improves the outcome of intra-arterial thrombolysis with tissue plasminogen activator Academic Article
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Benefit-risk ratios in the assessment of the clinical evidence of a new therapy Academic Article
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Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: A single‐center prospective longitudinal study Academic Article
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Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis Academic Article
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Characterization of the Interactions of Plasminogen and Tissue and Vampire Bat Plasminogen Activators with Fibrinogen, Fibrin, and the Complex of d-Dimer Noncovalently Linked to Fragment E Academic Article
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Comparison of the Efficacy of Pharmacoinvasive Management for ST-Segment Elevation Myocardial Infarction in Smokers Versus Non-Smokers (from the Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction) Academic Article
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Coronary patency, infarct size and left ventricular function after thrombolytic therapy for acute myocardial infarction: results from the tissue plasminogen activator: Toronto (TPAT) placebo-controlled trial Academic Article
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Coronary thrombolysis--clinical guidelines and public policy: results of an Ontario practitioner survey. Academic Article
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Dabigatran-related coagulopathy: when can we assume the effect has “worn off”? Academic Article
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Dialysis Catheters and Recombinant Tissue Plasminogen Activator Academic Article
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Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina? Academic Article
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Do potential patients prefer tissue plasminogen activator (TPA) over streptokinase (SK)? Academic Article
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Effect of ascorbate on fibrinolytic factors in septic mouse skeletal muscle Academic Article
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Effectiveness and safety of abciximab after failed thrombolytic therapy Academic Article
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Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema Academic Article
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Effects of tissue-type plasminogen activator and anisoylated plasminogen streptokinase activator complex on mortality in acute myocardial infarction. Academic Article
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Efficacy and safety of rivaroxaban versus placebo after lower extremity bypass surgery: A post hoc analysis of a “CASPAR like” outcome from VOYAGER PAD Academic Article
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Embolization of the deep cervical collaterals—a unique endovascular approach to prevent repeated posterior fossa strokes refractory to medical therapy Academic Article
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Emergence of the Primary Pediatric Stroke Center Academic Article
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Endovascular Thrombectomy for Acute Ischemic Stroke Academic Article
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Endovascular thrombectomy and intravenous alteplase in patients with acute ischemic stroke due to large vessel occlusion: A clinical practice guideline Academic Article
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Endovascular thrombectomy with or without intravenous alteplase for acute ischemic stroke due to large vessel occlusion: a systematic review and meta-analysis of randomized trials Academic Article
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Evaluation of low PAI‐1 activity as a risk factor for hemorrhagic diathesis Academic Article
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FIBRIN CLOT LYSIS BY TISSUE PLASMINOGEN ACTIVATOR (tPA) IS IMPAIRED IN PLASMA FROM PEDIATRIC PATIENTS UNDERGOING ORTHOTOPIC LIVER TRANSPLANTATION Academic Article
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Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists Academic Article
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Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group. Academic Article
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Fibrinolytic System in Adolescents: Response to Venous Occlusion Stress Tests Academic Article
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Fibrinolytic Variables in Patients with Recurrent Venous Thrombosis: a Prospective Cohort Study Academic Article
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Fibrinolytic properties of lysine-derivatized polyethylene in contact with flowing whole blood (Chandler loop model) Academic Article
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Fibrinolytic response to venous occlusion is decreased in patients after Kawasaki disease Academic Article
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Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ Academic Article
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Good is not Good Enough: The Benchmark Stroke Door-to-Needle Time Should be 30 Minutes Academic Article
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Graded exercise testing following thrombolytic therapy for acute myocardial infarction: the importance of timing and infarct location. TPAT Study Group. Academic Article
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Growth factors, tissue and urokinase-type plasminogen activators in venous ulcers. Academic Article
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Heparin enhances active site-dependent binding of tissue-type plasminogen activator to endothelial cells Academic Article
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Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen. Academic Article
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ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction Academic Article
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Identification of the Mechanism Responsible for the Increased Fibrin Specificity of TNK-Tissue Plasminogen Activator Relative to Tissue Plasminogen Activator Academic Article
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Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus Academic Article
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Impaired endothelial antithrombotic activity following short-term interruption of continuous subcutaneous insulin infusion in type1 diabetic patients Academic Article
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In acute ischemic stroke, early intraarterial treatment plus usual care improved functional independence Academic Article
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In intermediate-risk acute PE, tenecteplase plus heparin reduced hemodynamic decompensation but increased stroke. Academic Article
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In ischemic stroke, early intraarterial treatment plus alteplase improved reperfusion and functional outcome Academic Article
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In-Hospital Delays for Acute Stroke Treatment Delivery During the COVID-19 Pandemic Academic Article
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Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Academic Article
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Influence of Fibrinolytic Factors on Scar Formation After Lumbar Discectomy Academic Article
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Influence of changes in lifestyle on fibrinolytic parameters and recurrence rate in patients with venous thromboembolism Academic Article
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Interactions of fibrinolytic system proteins with lysine-containing surfaces Academic Article
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Interactions of plasminogen and fibrinogen with model silica glass surfaces: Adsorption from plasma and enzymatic activity studies Academic Article
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International differences in in-hospital revascularization and outcomes following acute myocardial infarction A multilevel analysis of patients in ASSENT-2 Academic Article
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Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial Academic Article
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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial Academic Article
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Laboratory evidence of hyperfibrinolysis in association with low plasminogen activator inhibitor type 1 activity Academic Article
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Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator. Academic Article
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Limited Fibrin Specificity of Tissue-type Plasminogen Activator and Its Potential Link to Bleeding Academic Article
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Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study. Academic Article
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Lysis of surface-localized fibrin clots by adsorbed plasminogen in the presence of tissue plasminogen activator Academic Article
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Management of a Patient with Catheter-Related Bloodstream Infection Academic Article
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Mechanism of Action of Plasminogen Activators Academic Article
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Now You See It, Now You Don’t? Academic Article
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Overutilization and underutilization of thrombolysis in routine clinical practice∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology. Academic Article
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Patterns of Stroke Transfers and Identification of Predictors for Thrombectomy Academic Article
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Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis Academic Article
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Plasma Urokinase Antigen and Plasminogen Activator Inhibitor-1 Antigen Levels Predict Angiographic Coronary Restenosis Academic Article
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Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor. Academic Article
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Practical Model-Based Dose Finding in Early-Phase Clinical Trials Academic Article
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Pre Admission Antithrombotics are Associated with Improved Outcomes following Ischaemic Stroke: A Cohort from the Registry of the Canadian Stroke Network Academic Article
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Predicting tissue plasminogen activator use and success in in-center hemodialysis patients Academic Article
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Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator Academic Article
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Prevention of catheter lumen occlusion with rT-PA versus heparin (Pre-CLOT): study protocol of a randomized trial [ISRCTN35253449] Academic Article
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Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators. Academic Article
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Reduced Dose Bolus Alteplase vs Conventional Alteplase Infusion for Pulmonary Embolism Thrombolysis Academic Article
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Reduced-Dose Intravenous Thrombolysis for Acute Intermediate–High-risk Pulmonary Embolism: Rationale and Design of the Pulmonary Embolism International THrOmbolysis (PEITHO)-3 trial Academic Article
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Reducing Door-to-Needle Time for Tissue Plasminogen Activator Administration in a Community Hospital: An Operations Study Academic Article
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Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells Academic Article
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Response to “Effect of Tissue Plasminogen Activator Dose and Interval on Stroke Severity” Academic Article
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Results of a Prospective Randomized Trial Evaluating Surgery Versus Thrombolysis for Ischemia of the Lower Extremity The STILE Trial Academic Article
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Seizures during stroke thrombolysis heralding dramatic neurologic recovery Academic Article
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Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Academic Article
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Soluble fibrin degradation products potentiate tissue plasminogen activator-induced fibrinogen proteolysis. Academic Article
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Stability and sterility of recombinant tissue plasminogen activator at −30°C Academic Article
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Standard and Low Molecular Weight Heparin Have no Effect on Tissue Plasminogen Activator Induced Plasma Clot Lysis or Fibrinogenolysis Academic Article
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Successful Use of Thrombolysis in an Extremely Low Birth Weight, Premature Infant With Aortic Thrombosis Academic Article
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Successful delayed thrombolysis with tissue plasminogen activator for recurrent arterial thrombosis secondary to protein S deficiency Academic Article
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Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure Academic Article
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Surgical management of submacular hemorrhage: experience at an academic Canadian centre Academic Article
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The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model Academic Article
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The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventricular Function, and Survival after Acute Myocardial Infarction Academic Article
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The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial Academic Article
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The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events: Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial Academic Article
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The relative kinetics of clotting and lysis provide a biochemical rationale for the correlation between elevated fibrinogen and cardiovascular disease Academic Article
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The role of platelets and platelet inhibition in acute myocardial infarction Academic Article
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The thrombolytic and hemorrhagic effects of tissue type plasminogen activator: Influence of dosage regimens in rabrits Academic Article
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The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study Academic Article
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Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors Academic Article
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Thrombin-activable Fibrinolysis Inhibitor Attenuates (DD)E-mediated Stimulation of Plasminogen Activation by Reducing the Affinity of (DD)E for Tissue Plasminogen Activator Academic Article
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Thrombolysis Despite Recent Stroke Academic Article
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Thrombolysis by chemically modified coagulation factor Xa Academic Article
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Thrombolysis for restoration of patency to haemodialysis central venous catheters: a systematic review. Academic Article
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Thrombolysis in Acute Childhood Stroke: Design and Challenges of the Thrombolysis in Pediatric Stroke Clinical Trial Academic Article
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Thrombolysis in Pediatric Stroke Study Academic Article
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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances Academic Article
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Thrombolytic therapy for pulmonary embolism: is it effective? Is it safe? When is it indicated? Academic Article
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Thrombolytic therapy for the treatment of acute pulmonary embolism. Academic Article
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Tissue Plasminogen Activator Academic Article
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Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes Academic Article
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Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers Academic Article
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Tissue plasminogen activator (rt-PA) vs heparin in deep vein thrombosis. Results of a randomized trial. Academic Article
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Tissue plasminogen activator-containing polyurethane surfaces for fibrinolytic activity Academic Article
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Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction Academic Article
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Treatment of acute ischemic stroke: from fibrinolysis to neurointervention Academic Article
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Type 1 Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin Academic Article
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Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study Academic Article
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Use of thrombolytic agents to treat neonatal thrombosis in clinical practice Academic Article
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Utility of Intravenous Alteplase Prior to Endovascular Stroke Treatment Academic Article
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Zinc delays clot lysis by attenuating plasminogen activation and plasmin-mediated fibrin degradation Academic Article
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[Canadian Consensus Conference on Coronary Thrombolysis--current aspects]. Academic Article