The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study Academic Article uri icon

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  • We evaluated the efficacy and safety of alteplase to restore central venous line (CVL) patency in a consecutive cohort study. A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children < or =10 kg, a dose of 0.5 mg was used; for children >10 kg, doses of 1 to 2 mg were used. The alteplase remained instilled for 1 to 4 hours or overnight. Retrospective data accrual found that 25 children received alteplase for a total of 34 courses; 29 (85%) of the 34 courses of alteplase completely restored CVL patency. Alteplase appears to be a safe and effective thrombolytic agent for CVL patency restoration in children.


  • Choi, Matthew
  • Massicotte, M Patricia
  • Marzinotto, Velma
  • Chan, Anthony
  • Holmes, Joanne L
  • Andrew, Maureen

publication date

  • July 2001