Journal article
Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes
Abstract
BACKGROUND: The dose of intravenous tissue plasminogen activator (tPA) administered in acute ischemic stroke patients is calculated using the patient's weight (0.9 mg/kg). Patients are rarely weighed before treatment in actual practice, although overestimating patient weights leads to higher doses of tPA, which may adversely influence outcome.
METHODS: We investigated the weight used to calculate the dose of tPA compared to the actual measured …
Authors
Sahlas DJ; Gould L; Swartz RH; Mohammed N; McNicoll-Whiteman R; Naufal F; Oczkowski W
Journal
Journal of Stroke and Cerebrovascular Diseases, Vol. 23, No. 1, pp. 155–159
Publisher
Elsevier
Publication Date
1 2014
DOI
10.1016/j.jstrokecerebrovasdis.2013.01.004
ISSN
1052-3057