Journal article
Lysis of surface-localized fibrin clots by adsorbed plasminogen in the presence of tissue plasminogen activator
Abstract
The ability of plasminogen adsorbed from buffer onto sulphonated silica glass or lysine-derivatized silica glass to lyse fibrin I clots has been investigated. Clots were formed around the test surface by adding reptilase to fibrinogen solutions in which the surfaces were immersed. Tissue plasminogen activator (t-PA) was then added and the extent of clot lysis was determined by measuring the levels of the specific plasmin cleavage product of …
Authors
Woodhouse KA; Weitz JI; Brash JL
Journal
Biomaterials, Vol. 17, No. 1, pp. 75–77
Publisher
Elsevier
Publication Date
1 1996
DOI
10.1016/0142-9612(96)80759-9
ISSN
0142-9612