Journal article
The thrombolytic and hemorrhagic effects of tissue type plasminogen activator: Influence of dosage regimens in rabrits
Abstract
Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals and in humans. We have previously observed that the thrombolytic effect of t-PA persists beyond its time of clearance from the circulation and that wound bleeding induced by a high dose infusion of t-PA is delayed for at least one and a half hours after commencing the infusion. These observations suggest that improved thrombolysis may be obtained …
Authors
Agnelli G; Buchanan MR; Fernandez F; Hirsh J
Journal
Thrombosis Research, Vol. 40, No. 6, pp. 769–777
Publisher
Elsevier
Publication Date
December 1985
DOI
10.1016/0049-3848(85)90314-7
ISSN
0049-3848